A5014542175- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Transcranial Magnetic Stimulation Studies
- Sleep and related disorders
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Advanced MRI Techniques and Applications
- Circadian rhythm and melatonin
- Eating Disorders and Behaviors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Dementia and Cognitive Impairment Research
- Mental Health Research Topics
- Neurobiology of Language and Bilingualism
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Visual perception and processing mechanisms
- Multiple Sclerosis Research Studies
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2009-2025
Amsterdam Neuroscience
2016-2025
University College London
2024
Stanford University
2024
Amsterdam UMC Location VUmc
2013-2023
Amsterdam University of Applied Sciences
2022
Netherlands Institute for Neuroscience
2011-2020
Center for Neurosciences
2011-2020
GGZ inGeest
2019
Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover heritable traits that are related to genetic susceptibility OCD. Deficient response inhibition is a promising endophenotype OCD, although its functional neural correlates have not been extensively studied. The authors sought determine the in large sample medication-free OCD patients and their unaffected siblings. Method Forty-one patients, 17 siblings, 37 matched healthy comparison subjects performed...
The thalamus, a crucial node in the well-described cortico-striatal-thalamo-cortical circuits, has been focus of functional and structural imaging studies investigating human emotion, cognition memory. Invasive work animals post-mortem investigations have revealed rich cytoarchitectonics specificity thalamus. Given current restrictions spatial resolution non-invasive modalities, there is, however, translational gap between information on these circuits humans as well histological cellular...
Abstract Numerous brain disorders demonstrate structural abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these connectomic vulnerabilities remain unknown, has yet be studied in a single multi-disorder framework. Using MRI morphometry the ENIGMA consortium, we construct maps cortical abnormalities for thirteen neurodevelopmental, neurological, psychiatric N = 21,000 participants 26,000 controls, collected...
Although subjective complaints about daytime cognitive functioning are an essential symptom of chronic insomnia, abnormalities in functional brain activation have not previously been investigated. This study was designed to investigate differences as a possible result and the reversibility these after nonmedicated sleep therapy.Insomniacs carefully matched controls underwent magnetic resonance imaging (fMRI) scanning during performance category letter fluency task. Insomniacs were randomly...
Although complaints of impaired daytime functioning are essential to the diagnosis primary insomnia, objective evidence for cognitive dysfunction has been hard establish. A prerequisite understanding neurocognitive consequences insomnia is establish task paradigms that robustly differentiate insomniacs from well-sleeping subjects. We hypothesized decline in performance typically occurs with an increasing demand would provide a more sensitive measure than on single version. The hypothesis was...
Our study uses the combined transcranial magnetic stimulation/positron emission tomography (TMS/PET) method for elucidating neural connectivity of human motor system. We first altered excitability by applying low-frequency repetitive TMS over two cortical regions in separate experiments: dorsal premotor and primary cortices. then assessed consequences modulating single-pulse cortex measuring: 1) muscle responses with electromyography 2) cerebral blood flow PET. Low-frequency stimulation...
The characteristic oscillations of the sleeping brain, spindles and slow waves, show trait-like, within-subject stability a remarkable interindividual variability that correlates with functionally relevant measures such as memory performance intelligence. Yet, mechanisms underlying these differences are largely unknown. Spindles waves affected by recent history learning neuronal activation, indicating sensitivity to changes in synaptic strength thus connectivity network. Because structural...
The restorative effect of sleep on waking brain activity remains poorly understood. Previous studies have compared overall neural network characteristics after normal and deprivation. To study whether deprivation might differentially affect subsequent connectivity in different regions, we performed a within-subject resting state using the graph theory framework adapted for individual electrode level. In balanced order, obtained high-density electroencephalography (EEG) 8 healthy...
The mechanisms underlying hyperarousal, the key symptom of insomnia, have remained elusive, hampering cause-targeted treatment. Recently, restless rapid-eye-movement (REM) sleep emerged as a robust signature in insomnia. Given role REM emotion regulation, we hypothesized that could interfere with overnight resolution emotional distress, thus contributing to accumulation arousal. Participants (n = 1,199) completed questionnaires on insomnia severity, self-conscious and thought-like nocturnal...
Depression is a common neuropsychiatric symptom in Parkinson's disease (PD). In previous research, PD-related depression was associated with striatal dopaminergic deficits, presumably due to degeneration of brainstem projections. Segregated areas the striatum are crucially involved various parallelly arranged cortical-striatal-thalamocortical circuits and serve functions in, among others, motor control or emotion. This suggests regional specificity deficits depressive symptoms PD.In this...
Insomnia is prevalent, severe and partially heritable. Unfortunately, its neuronal correlates remain enigmatic, hampering the development of mechanistic models rational treatments. Consistently reported impairments concern fragmented sleep, hyper-arousal executive dysfunction. Because fronto-striatal networks could well play a role in arousal regulation functioning, present series studies used an task to evaluate functioning disturbed sleep. Patients with insomnia showed reduced recruitment...
Eigenvector centrality mapping (ECM) has recently emerged as a measure to spatially characterize connectivity in functional brain imaging by attributing network properties voxels. The main obstacle for widespread use of ECM magnetic resonance (fMRI) is the cost computing and storing matrix. This article presents fast (fECM), an efficient algorithm estimate voxel-wise eigenvector centralities from fMRI time series. Instead explicitly matrix, fECM computes matrix-vector products directly data,...
Impulse control disorders (ICD) are relatively common in Parkinson's disease (PD) and generally regarded as adverse effects of dopamine replacement therapy, although certain demographic clinical risk factors also involved. Previous single-photon emission computed tomography (SPECT) studies showed reduced ventral striatal transporter binding Parkinson patients with ICD compared without. Nevertheless, these were performed preexisting impulse impairments, which impedes clear-cut interpretation...