A5019961131- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Eating Disorders and Behaviors
- Advanced Neuroimaging Techniques and Applications
- Palliative Care and End-of-Life Issues
- Neural and Behavioral Psychology Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer survivorship and care
- Sexual function and dysfunction studies
- Fetal and Pediatric Neurological Disorders
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Family Support in Illness
- Psychosomatic Disorders and Their Treatments
- Neuroblastoma Research and Treatments
- Spinal Dysraphism and Malformations
- Child Nutrition and Feeding Issues
- Childhood Cancer Survivors' Quality of Life
- Patient Satisfaction in Healthcare
- Patient-Provider Communication in Healthcare
- Neuroscience and Music Perception
The Netherlands Cancer Institute
2020-2022
University Health Network
2022
Princess Margaret Cancer Centre
2022
University of Toronto
2022
Amsterdam Neuroscience
2012-2020
Amsterdam University Medical Centers
2020
Amsterdam UMC Location VUmc
2012-2019
University of Groningen
2018
GGZ inGeest
2016
University Medical Center
2016
Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover heritable traits that are related to genetic susceptibility OCD. Deficient response inhibition is a promising endophenotype OCD, although its functional neural correlates have not been extensively studied. The authors sought determine the in large sample medication-free OCD patients and their unaffected siblings. Method Forty-one patients, 17 siblings, 37 matched healthy comparison subjects performed...
Fragile X mental retardation is caused by absence of the RNA-binding protein fragile (FMRP), encoded FMR1 gene. There increasing evidence that FMRP regulates transport and modulates translation some mRNAs. We studied neurotransmitter-activated synaptic synthesis in fmr1-knockout mice. Synaptoneurosomes from knockout mice did not manifest accelerated polyribosome assembly or as it occurs wild-type upon stimulation group I metabotropic glutamate receptors. Direct activation kinase C compensate...
Abstract Background Recent studies have shown that response inhibition is impaired in patients with obsessive–compulsive disorder and their unaffected siblings, suggesting these deficits may be considered a cognitive endophenotype of disorder. Structural functional neural correlates altered been identified siblings. This study aims to examine the integrity network Methods Forty‐one unmedicated disorder, 17 siblings 37 healthy controls performed stop signal task during magnetic resonance...
Objectives: Executive network deficits are putative neurocognitive endophenotypes for obsessive-compulsive disorder (OCD). Yet, unlike alterations in fronto-striatal and limbic connectivity, connectivity the fronto-parietal (FPN) cingulo-opercular (CON) networks involved cognitive control has received little attention.Methods: The coherence of FPN, CON fronto-limbic was investigated 39 unmedicated OCD patients, 16 their unaffected siblings 36 healthy controls using resting-state...
Objective: Obsessive-compulsive disorder (OCD) is a common neuropsychiatric with moderate genetic influences and white matter abnormalities in frontal-striatal limbic regions. Inconsistencies reported results from diffusion tensor imaging (DTI) studies can be explained, at least partly, by medication use between-group differences disease profile stage. We used family design aiming to establish whether abnormalities, if present un-medicated OCD patients, also exist their unaffected siblings....
Article Abstract Objective: The tic-related subtype of obsessive-compulsive disorder (OCD) has a distinct clinical profile. course OCD previously been investigated in treatment studies, with inconclusive results. This study aimed to compare profiles between and tic-free patients establish the influence tics on 2-year natural adult patients. Methods: Within Netherlands Association cohort, 377 current DSM-IV diagnosis were divided into group (28%) compared variables t tests or χ2 tests. Linear...
Objective The need for symmetry and ordering objects related to a “just right”-feeling is common symptom in Tourette's syndrome (TS) resembles behavior obsessive-compulsive disorder, but its pathophysiology unknown. We used provocation paradigm investigate the neural correlates of TS hypothesized involvement frontal-striatal limbic brain areas. Methods Pictures asymmetrically symmetrically arranged were presented randomized blocks (4 each condition) 14 patients with 10 matched healthy...
The Clinical Evaluation Questionnaire (CEQ) is a patient-reported experience measure (PREM) that assesses the perceived benefit of therapeutic interactions patients with advanced cancer their healthcare providers concerning issues relevant to illness. It was developed for randomised controlled trial Managing Cancer and Living Meaningfully (CALM), brief supportive-expressive therapy cancer. present study evaluates preliminary psychometric properties CEQ. Patients in CALM usual care groups...
Patients with small intestine neuroendocrine tumours (SINETs) face various disease-related symptoms that can affect their social functioning and quality of life. The present study aimed to explore the consequences in patients a metastatic SINET develop theory on how these experience disease. were eligible when they diagnosed between 2009 2016 younger than 60 years age during diagnosis, had good functional performance status. Semi-structured interviews conducted January June 2018. Data...
Background: The role of gender in psychotherapy has been widely recognized but infrequently investigated trials. We conducted a secondary analysis data from randomized controlled trial Managing Cancer and Living Meaningfully (CALM), supportive-expressive intervention for individuals with advanced cancer, to examine effects the feasibility, acceptability, perceived benefit, effectiveness CALM. Methods: Trial participants, outpatients cancer (N = 305, 40% men 60% women), completed measures at...