A5027815153- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Eating Disorders and Behaviors
- Child Nutrition and Feeding Issues
- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Virology and Viral Diseases
- Receptor Mechanisms and Signaling
- Body Image and Dysmorphia Studies
- Substance Abuse Treatment and Outcomes
- Prenatal Screening and Diagnostics
- Youth Substance Use and School Attendance
- Schizophrenia research and treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Psychosomatic Disorders and Their Treatments
- Behavioral and Psychological Studies
- Infant Health and Development
University of Michigan
2015-2024
Kyoto Prefectural University of Medicine
2016-2017
Michigan United
2005-2015
Brigham and Women's Hospital
2014
Harvard University
2014
Massachusetts General Hospital
2014
Center for Human Genetics
2014
Broad Institute
2014
University of Chicago
1998-2013
University of Illinois Chicago
2008
Abstract Copy number variations (CNVs) are implicated across many neurodevelopmental disorders (NDDs) and contribute to their shared genetic etiology. Multiple studies have attempted identify etiology among NDDs, but this is the first genome-wide CNV analysis autism spectrum disorder (ASD), attention deficit hyperactivity (ADHD), schizophrenia (SCZ), obsessive-compulsive (OCD) at once. Using microarray (Affymetrix CytoScan HD), we genotyped 2,691 subjects diagnosed with an NDD (204 SCZ,...
<h3>Context</h3> The first 2 independent linkage studies for obsessive-compulsive disorder (OCD) identified a region on 9p24 with suggestive evidence linkage. glutamate transporter gene solute carrier family 1, member 1 (<i>SLC1A1</i>) is promising functional candidate in this because altered glutamatergic concentrations have been found the striatum and anterior cingulate neuroimaging of pediatric OCD. <h3>Objective</h3> To determine whether genotypes at polymorphisms the<i>SLC1A1</i>gene...
Abstract The goal of this study was to identify chromosomal regions likely contain susceptibility alleles for early‐onset obsessive‐compulsive disorder (OCD). A genome scan done in 56 individuals from seven families ascertained through pediatric OCD probands; 27 the subjects had a lifetime diagnosis definite OCD. Denser mapping on chromosomes 2, 9, and 16 subsequently with those ten additional largest family study. Direct interviews were completed 65 66 genotyped individuals. Relatives...
Abstract Obsessive‐compulsive disorder (OCD) is a heterogeneous of unknown etiology. We examined the lifetime history obsessions, compulsions, and OCD in first‐ second‐degree relatives 35 pediatric probands with 17 controls no psychiatric diagnosis. All available first‐degree were directly interviewed blind to proband status two semi‐structured interviews. Parents also systematically assess family relatives. Best‐estimate diagnoses made using all sources information. Data analyzed logistic...
Background The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. error-related negativity (ERN) is a negative deflection event-related potential following an erroneous response and thought to reflect ACC activity. This study was done assess ERN as biomarker for OCD by comparing amplitudes pediatric patients, unaffected siblings healthy controls. Methods...
Objective: Brain imaging communities focusing on different diseases increasingly start collaborating and pooling data to perform well-powered meta- mega-analyses. Some methodologists claim that a one-stage individual-participant mega-analysis can be superior two-stage aggregated meta-analysis, since more detailed computations performed in mega-analysis. Before definitive conclusions regarding the performance of either method drawn, it is necessary critically evaluate methodology of, results...
A functional polymorphism in the regulatory region of serotonin transporter gene (5-HTTLPR) is considered to be a plausible candidate for anxiety-related personality traits and alcoholism. Empirical support association between 5-HTTLPR psychological has been somewhat inconsistent; however, observations dominance low-activity s-allele over l-allele have more consistent. When studying influence particular genes on traits, it seems useful also assess biological intermediate that may mediate...
ABSTRACT Startle modulation was induced by prestimulation in 43, 6–11 year old boys with attention‐deficit hyperactivity disorder (ADHD), 13 of whom were or had been enuretic, 17 age‐matched enuretic boys, and 42 normal using 60‐ms 120‐ms intervals a 4000‐ms continuous tone. There significant multivariate effect enuresis on startle amplitude modulation. This attributed primarily to the reduction inhibition following interval regardless whether not associated ADHD. no ADHD prestimulation. The...
Obsessive-compulsive disorder (OCD) is a heterogeneous neuropsychiatric condition, thought to have significant genetic component. When onset occurs in childhood, affected individuals generally exhibit different characteristics from adult-onset OCD, including higher prevalence males and increased heritability. Since conditions are associated with copy number variations (CNVs), we considered their potential role the etiology of OCD. We genotyped 307 unrelated pediatric probands idiopathic OCD...