A5101958058- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Mosquito-borne diseases and control
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Pacific and Southeast Asian Studies
- Diet and metabolism studies
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Malaria Research and Control
- Neurobiology and Insect Physiology Research
- Personality Disorders and Psychopathology
- Visual perception and processing mechanisms
- Viral Infections and Vectors
- Spatial Neglect and Hemispheric Dysfunction
- Schizophrenia research and treatment
- Insect and Arachnid Ecology and Behavior
- Cultural Heritage Management and Preservation
AbbVie (United States)
2022-2025
Humboldt-Universität zu Berlin
2016-2025
Freie Universität Berlin
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
Sunovion (United States)
2019
Otto-von-Guericke University Magdeburg
2019
University of East Anglia
2010-2018
Kyoto Prefectural University of Medicine
2016-2017
Humboldt State University
2007-2017
University of Zurich
1996-2015
Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and basal ganglia, but it is unclear whether these areas are also characterized by altered network properties.To determine regions abnormal degree connectivity patients with OCD to investigate measures affected antidepressant medication OCD.Case-control cross-sectional study using resting-state functional magnetic resonance imaging a data-driven, model-free...
Regional differences in sleep EEG dynamics indicate that sleep-related brain activity involves local processes with stage specific patterns of neuronal populations. Macroscopically, it is not fully understood which cerebral regions are involved the successive discontinuation wakefulness. We simultaneously used and functional MRI on 9 subjects (6 female: mean = 24.1 years, 3 male: 26.0 years) analyzed blood oxygenation level dependent signal changes linked to transition from wakefulness...
Objective: Hyperactivity in frontal-striatal circuits is assumed to be involved the pathophysiology of obsessive-compulsive disorder (OCD). In line with that, electrocortical correlates overactive performance monitoring have been found associated OCD independent from symptom state. The purpose present study was elucidate whether may represent a candidate endophenotype for OCD. this case, unaffected first-degree relatives patients should also show trait. Method: Amplitudes error-related...
Abstract High thalamocortical neuronal activity characterizes both, wakefulness and rapid eye movement (REM) sleep, but apparently this network fulfills other roles than processing external information during REM sleep. To investigate thalamic cortical reactivity human we used functional magnetic resonance imaging with simultaneous polysomnographic recordings while applying acoustic stimulation. Our observations indicate two distinct substates within general Acoustic stimulation elicited a...
Abstract Prominent local decreases in blood oxygenation level (BOLD) can be observed by functional magnetic resonance imaging (fMRI) upon acoustic stimulation during sleep. The goal of this study was to further characterize BOLD signal decrease with respect corresponding neurophysiological phenomena using a simultaneous electroencephalography (EEG)/fMRI approach sleeping human subjects. Healthy volunteers were subjected non‐rapid eye movement (NREM) On the basis statistical parametric maps,...
Complaints about a biting pest led to the recognition of invasive Aedes (Finlaya) japonicus (Theobald) (Diptera: Culicidae) in Central Europe. Larval collections from cemetery vases revealed colonized area approximately 1400 km(2) northern Switzerland spreading into bordering Germany, suggesting that mosquito has been established this region for several years. Within range, larvae Ae. were recovered more containers than most common resident culicid species Culex pipiens. Possible...
Anxiety disorders have been linked to a hyperactivated cortico-amygdalar circuitry, but the amygdala's role in pathophysiology of obsessive-compulsive disorder (OCD) remains unclear. This fMRI study examined cortico-limbic correlates individually tailored symptom provocation 14 unmedicated OCD patients and controls. In addition OCD-relevant pictures, aversive neutral control stimuli were included. Patients showed increased fronto-striatal activation contrasted with both categories. Briefly...
Abstract Background Increased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently depression. Reduced substance use disorders (SUD). Thus, alterations error-monitoring are proposed as a transdiagnostic endophenotype. To strengthen this notion, data from unaffected individuals with family history for the respective needed. Methods The error-related negativity (ERN) indicator of was measured during flanker task 117 OCD patients,...
Despite a rising social relevance of pathological computer game playing, it remains unclear whether the neurobiological basis this addiction-like behavioral disorder and substance-related addiction are comparable. In addiction, attentional bias cue reactivity often observed. We conducted functional magnetic resonance study using dot probe paradigm with short-presentation (attentional bias) long-presentation (cue reactivity) trials in eight male players (PCGPs) nine healthy controls (HCs)....
Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role corticostriatal brain regions, studies default mode network integrity have garnered increasing interest, but produced conflicting results.To resolve these discrepant findings by examining subsystems in OCD.Comparison seed-based resting-state functional connectivity 11 components between 46 patients with OCD and controls using magnetic resonance imaging.Significantly reduced within...
Objective: Brain imaging communities focusing on different diseases increasingly start collaborating and pooling data to perform well-powered meta- mega-analyses. Some methodologists claim that a one-stage individual-participant mega-analysis can be superior two-stage aggregated meta-analysis, since more detailed computations performed in mega-analysis. Before definitive conclusions regarding the performance of either method drawn, it is necessary critically evaluate methodology of, results...
Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to common trajectories development maturation.Large-scale investigation obsessive-compulsive disorder (OCD) may provide clues the pathophysiology this neurodevelopmental disorder.Using T 1 -weighted MRI scans acquired from 1616 individuals with OCD 1463 healthy controls across 37 datasets participating ENIGMA-OCD Working Group, we calculated intra-individual (using...
Autism Spectrum Disorder (ASD) and alexithymia are both linked to difficulties in facial affect recognition (FAR) alongside differences social brain activity. According the Alexithymia Hypothesis, emotion processing ASD can be attributed increased levels of co-occurring alexithymia. Despite substantial evidence supporting hypothesis at behavioral level, effects on function during FAR remain unexplored. Data from 120 participants (60 ASD, 60 controls) who completed an task were analyzed using...
Abstract In our natural environment, the ability to divide attention is essential since we attend simultaneously a number of sensory modalities, e.g., visual and auditory stimuli. this study, functional magnetic resonance imaging (fMRI) was used study brain activation while divided task performed. Brain also assessed under selective attention. Fourteen healthy male subjects aged between 19 28 years underwent fMRI studies using gradient EPI sequences. Cingulate evident in all tasks. Focusing...
In animal models, ponto-geniculo-occipital waves appear as an early sign of rapid eye movement sleep and may be functionally significant for brain plasticity processes. this pilot study, we use a combined polysomnographic functional magnetic resonance imaging approach, show distinct signal increases in the posterior thalamus occipital cortex close temporal relationship to movements during human sleep. These findings are consistent with cell recordings experiments demonstrate that can...
The Asian bush mosquito Aedes japonicus (Theobald, 1901) (=Ochlerotatus (sensu Reinert et al., 2004) =Hulecoeteomyia japonica 2006)), has invaded large parts of North America and recently started to spread in Central-Western Europe. species is suspected act as a bridge vector West Nile virus but nothing or very little known about its competence for Chikungunya Dengue viruses. Here, we report on experiments laboratory infections Ae. with CHIKV DENV, demonstrating that the potential both...