Benno Pütz
A5040116842- Stress Responses and Cortisol
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Neural dynamics and brain function
- Hormonal Regulation and Hypertension
- Restless Legs Syndrome Research
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Bioinformatics and Genomic Networks
- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Motor Control and Adaptation
- Genetic Mapping and Diversity in Plants and Animals
- NMR spectroscopy and applications
- Genomic variations and chromosomal abnormalities
- Diet and metabolism studies
- Congenital heart defects research
Max Planck Institute of Psychiatry
2015-2024
Max Planck Society
2005-2015
Istituto Nazionale di Riposo e Cura per Anziani
2009
Biogen (Germany)
2004
Sophien-und Hufeland Klinikum
2004
University of Milan
2004
Istituti di Ricovero e Cura a Carattere Scientifico
2004
Institute of Neurological Sciences
2004
Universidade do Estado do Rio de Janeiro
2004
Universidade Federal Fluminense
2004
We studied the neural correlates of visuomotor sequence learning using functional magnetic resonance imaging (fMRI). In test condition, subjects learned, by trial and error, correct order pressing two buttons consecutively for 10 pairs (2 x task); in control they pressed any order. Comparison between condition revealed four brain areas specifically related to learning: dorsolateral prefrontal cortex (DLPFC), presupplementary motor area (pre-SMA), precuneus, intraparietal sulcus (IPS). found...
Apoptosis is a form of cell death involved in the regulation number various organs and tumors. Quantitative determination loss through apoptosis histological sections requires, addition to counts apoptotic cells, Information on duration histologically visible stages apoptosis. Here we describe method determine (i) normal (ii) putative preneoplastic tissue liver. Fenmie rats were treated with high doses hepatomitogen cyproterone acetate (CPA) induce liver hyperplasia. After stopping CPA...
The immune system plays a major role in human health and disease, understanding genetic causes of interindividual variability responses is vital. Here, we isolate monocytes from 134 genotyped individuals, stimulate these cells with three defined microbe-associated molecular patterns (LPS, MDP, 5'-ppp-dsRNA), profile the transcriptomes at time points. Mapping expression quantitative trait loci (eQTL), identify 417 response eQTLs (reQTLs) varying effects between conditions. We characterize...
1. Using functional magnetic resonance imaging, we investigated the neural correlates of sequential procedural learning. During test scans subjects learned a new sequence (position or color) button presses; during control they pressed buttons in any order. The comparison and was expected to reveal activities related learning, not sensory-motor processes. 2. We found that localized area what regard be human homologue presupplementary motor (pre-SMA) particularly active for learning procedures...
For >15 generations, CD1 mice have been selectively and bidirectionally bred for either high-anxiety-related behavior (HAB-M) or low-anxiety-related (LAB-M) on the elevated plus-maze. Independent of gender, HAB-M were more anxious than LAB-M animals in a variety additional tests, including those reflecting risk assessment behaviors ultrasound vocalization, with unselected “normal” control (NAB-M) cross-mated (CM-M) displaying intermediate behavioral scores most cases. Furthermore, both...
PURPOSE: To differentiate lesion patterns in patients with cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy (CADASIL) from those sporadic arteriosclerotic encephalopathy (sSAE). MATERIALS AND METHODS: Magnetic resonance (MR; T2-weighted fluid-attenuated inversion-recovery) images obtained 28 CADASIL were compared 24 sSAE by using an automated pixel-based group comparison statistical parametric mapping regional semiquantitative rating. RESULTS: Visual...
Polymorphisms in the gene encoding glucocorticoid receptor (GR) regulating co-chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an increased risk develop posttraumatic stress disorder (PTSD).To investigate interactions of single-nucleotide polymorphism rs9296158 PTSD symptoms on baseline cortisol level, low-dose dexamethasone suppression, whole-blood expression.Association genotypes endocrine measures genome-wide expression profiles.Waiting rooms general medical...
Severe stress exposure increases the risk of stress-related disorders such as major depressive disorder (MDD). An essential characteristic MDD is impairment social functioning and lack motivation. Chronic defeat an established animal model for research, which induces a cascade physiological behavioral changes. Current markerless pose estimation tools allow more complex naturalistic tests. Here, we introduce open-source tool DeepOF to investigate individual profile in mice by providing...
In preceding studies (Hikosaka et al., 1996; Sakai 1998) we have shown that the presupplementary motor area (pre-SMA), an anterior part of medial premotor cortex, is active during visuo-motor sequence learning. However, paradigm required subjects first to acquire correct association and then sequence, it was still unknown which two processes pre-SMA involved in. To further characterize role pre-SMA, conducted another series functional magnetic resonance imaging experiments using three...
Watanabe, Takeo, Yuka Sasaki, Satoru Miyauchi, Benno Putz, Norio Fujimaki, Matthew Nielsen, Ryosuke Takino, and Satoshi Miyakawa. Attention-regulated activity in human primary visual cortex. J. Neurophysiol. 79: 2218–2221, 1998. Effects of attention to a local contour moving object on the activation cortex (area V1) were examined. Local cerebral oxygenation changes (an index neuronal activity) area V1 measured with functional magnetic resonance imaging (fMRI) conditions including following...