A5109251570- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Maternal Mental Health During Pregnancy and Postpartum
- Mental Health Treatment and Access
- Obsessive-Compulsive Spectrum Disorders
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Substance Abuse Treatment and Outcomes
- Psychosomatic Disorders and Their Treatments
- Cannabis and Cannabinoid Research
- Suicide and Self-Harm Studies
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Prenatal Substance Exposure Effects
- Health and Medical Studies
- Psychiatric care and mental health services
- COVID-19 and Mental Health
- Child Abuse and Trauma
- Adolescent and Pediatric Healthcare
- Tryptophan and brain disorders
- Resilience and Mental Health
- Eating Disorders and Behaviors
- Neuroendocrine regulation and behavior
- Attention Deficit Hyperactivity Disorder
University of Basel
2015-2024
Max Planck Institute of Psychiatry
2009-2018
University of Zurich
2016
Max Planck Society
2004-2014
TU Dresden
1998-2010
Ankara University
2010
National Institute of Mental Health
2010
Maastricht University
2004
Inserm
2004
Hôpital Albert-Chenevier
2004
Background. The German National Health Interview and Examination Survey (GHS) is the first government mandated nationwide study to investigate jointly prevalence of somatic mental disorders within one in general adult population Germany. This paper reports results from its Mental Supplement (GHS-MHS) on 4-week 12-month, selected lifetime a broad range DSM-IV disorders, their co-morbidity correlates community. Methods. sample GHS-MHS ( n =4181; multistage stratified random drawn registries;...
<h3>Abstract</h3> <b>Objective</b> To investigate the relation between cannabis use and psychotic symptoms in individuals with above average predisposition for psychosis who first used during adolescence. <b>Design</b> Analysis of prospective data from a population based sample. Assessment substance use, psychosis, was on standardised personal interviews at baseline follow up four years later. <b>Participants</b> 2437 young people (aged 14 to 24 years) without psychosis. <b>Main outcome...
Epidemiological findings demonstrating an increased risk for individuals with social anxiety disorder (SAD) to develop depression have been challenged by discrepant from prospective longitudinal examinations in childhood and early adolescence.To examine patterns of SAD incidence, the consistency associations subsequent depression, distal proximal predictors depression.Face-to-face, 10-year family study up 4 waves. The DSM-IV Munich-Composite International Diagnostic Interview was...
<h3>Background</h3> Social anxiety disorder (SAD) (also known as "social phobia") is frequently comorbid with major depression, and in such cases, almost always precedes it. This has led to interest SAD a possible modifier of the risk and/or course mood disorders. <h3>Methods</h3> Data come from prospective, longitudinal epidemiologic study adolescents young adults (aged 14-24 years) Munich, Germany. Respondent diagnoses (N = 2548) at baseline follow-up (34-50 months later) are considered....
Background. Despite an abundance of clinical research on premenstrual and menstrual symptoms, few epidemiological data provide estimates the prevalence, incidence, co-morbidity, stability correlates dysphoric disorder (PMDD) in community. Aims. To describe 12 co-morbidity factors threshold subthreshold PMDD a community sample young women. Methods. Findings are based prospective–longitudinal survey 1488 women aged 14–24, who were followed-up over period 48 months (follow-up, N = 1251) as part...
This article examines associations between DSM-IV depressive disorders, their natural course, other psychopathology, and parental major depression in a community sample of adolescents young adults.Baseline 4-year follow-up data were used from the Early Developmental Stages Psychopathology Study, prospective-longitudinal study adults. Results are based on 2427 subjects who completed for whom diagnostic information both parents was available. mental disorders respondents assessed using...
Background: This article examines the associations between DSM-IV social phobia and parental psychopathology, parenting style, characteristics of family functioning in a representative community sample adolescents.Methods: Findings are based on baseline first follow-up data 1047 adolescents aged 14 to 17 years at (response rate, 74.3%), independent diagnostic interviews with one their parents.Diagnostic assessments parents were algorithms Munich-Composite International Diagnostic...
<h3>Context</h3> Controversy surrounds the diagnostic categorization of generalized anxiety disorder (GAD). <h3>Objectives</h3> To examine incidence, comorbidity, and risk patterns for depressive disorders to test whether developmental features GAD more strongly support a view this condition as opposed an disorder. <h3>Design</h3> Face-to-face, 10-year prospective longitudinal family study with many 4 assessment waves. The<i>DSM-IV</i>Munich Composite International Diagnostic Interview was...
It is commonly assumed that there are clear lines of demarcation between anxiety and depressive disorders on the one hand psychosis other. Recent evidence, however, suggests this principle may be in need updating. Depressive and/or disorders, with no previous history psychotic disorder, were examined for presence symptoms a representative community sample adolescents young adults (Early Developmental Stages Psychopathology study; n = 3021). Associations consequences symptomatology course...
The reported link between psychological trauma and onset of psychosis remains controversial.To examine associations self-reported psychotic symptoms as a function prior evidence vulnerability to (psychosis proneness).At baseline, 2524 adolescents aged 14-24 years provided self-reports on proneness, at follow-up (on average 42 months later) participants were interviewed for presence symptoms.Self-reported was associated with symptoms, in particular more severe levels (adjusted OR 1.89, 95%...
The FKBP5 gene modulates function of glucocorticoid receptors and has been frequently studied as a risk factor for depression suicidality. This long-term study found gene-by-environment effect minor variants in the presence trauma but not deprivation.
Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (OXTR) brain-derived neurotrophic factor (BDNF ). The cross sectional study took place at the Division of Theoretical Clinical Psychobiology, University Trier, Germany was conducted from February August 2009. included 83 participants aged 61–67 years. Thereof, 76...
Background/Objective: Prolonged stress can overwhelm coping resources, leading people to seek mental health care. Acceptance and commitment therapy (ACT) is an intervention that enhances well-being reduces distress, assumedly by means of increasing psychological flexibility (PF). We examined the association between a total increase in PF during decreases increases after intervention. Method: The was randomized controlled trial ACT-based self-help Participants were 91 individuals reporting...
Background. Cross-sectional findings in community surveys of adults suggest that adolescent anxiety disorders are strong predictors the subsequent onset alcohol use, abuse and dependence. However, prospective data follow a sample adolescents into adulthood needed to confirm these associations. Method. Baseline 4-year follow-up from EDSP-Study, survey 3021 (2548 at follow-up) young aged 14 24 years baseline carried out Munich, were used. DSM-IV disorders, use assessed with...
Background. Research suggests that low-grade psychotic experiences in the general population are a common but transitory developmental phenomenon. Using two independent samples, hypothesis was examined common, non-clinical expression of psychosis may become abnormally persistent when synergistically combined with exposures impact on behavioural and neurotransmitter sensitization such as cannabis, trauma urbanicity.Method. The amount synergism estimated from additive statistical interaction...
Article AbstractObjective: The goal of this study was to examine the associations between specific anxiety disorders and risk major depressive disorder explore role various clinical characteristics in these relationships using a prospective, longitudinal design. Method: data are from 4-year community study, which included both baseline follow-up survey on 2548 adolescents young adults aged 14 24 years at baseline. DSM-IV diagnoses were made Munich-Composite International Diagnostic...
<h3>Context</h3> There is growing evidence that major depressive disorder (MDD) might be overdiagnosed at the expense of bipolar (BPD). <h3>Objectives</h3> To identify a subgroup subthreshold BPD among<i>DSM-IV</i>MDD, which distinct from pure MDD regarding range validators bipolarity, and to examine pattern these among different groups with affective disorders. <h3>Design</h3> Ten-year prospective longitudinal family study including 3 follow-up waves. Data were assessed...