Andrea Pfennig
A5073090214- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Psychiatric care and mental health services
- Adolescent and Pediatric Healthcare
- Health and Medical Studies
- Genetic Associations and Epidemiology
- Mental Health Treatment and Access
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Electroconvulsive Therapy Studies
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Treatment of Major Depression
- Mental Health Research Topics
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Stress Responses and Cortisol
- COVID-19 and Mental Health
- Suicide and Self-Harm Studies
- Psychological and Temporal Perspectives Research
- Sleep and related disorders
- Clinical practice guidelines implementation
- Health, psychology, and well-being
- Mental Health and Psychiatry
University Hospital Carl Gustav Carus
2016-2025
TU Dresden
2016-2025
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2014-2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2014-2023
Philipps University of Marburg
2021-2023
Oslo University Hospital
2015-2023
University of Oslo
2021-2023
Goethe University Frankfurt
2021-2022
Charité - Universitätsmedizin Berlin
2004-2022
MSB Medical School Berlin
2022
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
Objectives. This 2013 update of the practice guidelines for biological treatment unipolar depressive disorders was developed by an international Task Force World Federation Societies Biological Psychiatry (WFSBP). The goal has been to systematically review all available evidence pertaining disorders, and produce a series recommendations that are clinically scientifically meaningful based on evidence. intended use physicians seeing treating patients with these conditions. Methods. conducted...
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying sources of can help generate novel clinical hypotheses etiology assist in development biomarkers for indexing disease progression prognosis. Here we were interested case-control differences intracranial volume (ICV) each eight subcortical measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a...
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
In a previous meta-analysis of randomized controlled trials comparing lithium with placebo as long-term treatment in bipolar disorders, we observed clear preventative effect for manic episodes; however, the was equivocal depressive episodes. Since then, evidence base has grown further. this update, furthermore present data on efficacy comparison to alternative drug treatments. addition, analyze and other treatments regarding drop-outs due reasons than mood episode completion study (no no...
Everyday and clinical experience demonstrate strong interactions between emotions cognitions. Nevertheless the neural correlates underlying emotional-cognitive interaction remain unclear. Using event-related fMRI, we investigated BOLD-signal increases decreases in medial lateral prefrontal cortical regions during emotional non-emotional judgment of photographs taken from International Affective Picture System (IAPS). Emotional conditions were compared to each other as well with baseline...
For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium effectively augment antidepressant drugs treatment of refractory major depressive episodes prevent relapses recurrent unipolar depression. In contrast many psychiatric drugs, outlasted various...
Objectives: Significant questions remain regarding both the incidence patterns of mood episodes in adolescents and young adults from community conversion rate unipolar to bipolar disorders. We addressed these issues by examining data a prospective longitudinal study (i) determine cumulative disorders first three decades life; (ii) risk for onset depression among individuals with previous history hypomanic/manic vice versa; (iii) clinical treatment characteristics subjects. Methods: Using...
<h3>Importance</h3> Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, efficacy lithium varies widely, with nonresponse rate up to 30%. Biological response markers are lacking. Genetic factors thought mediate lithium, and there previously reported genetic overlap between BPAD schizophrenia (SCZ). <h3>Objectives</h3> To test whether polygenic score SCZ associated in explore potential molecular underpinnings this association. <h3>Design,...
Background Neuroimaging studies have demonstrated an association between lithium (Li) treatment and brain structure in human subjects. A crucial unresolved question is whether this reflects direct neurochemical effects of Li or indirect secondary to prevention episodes bipolar disorder (BD). Method To address knowledge gap, we compared manually traced hippocampal volumes 37 BD patients with at least 2 years (Li group), 19 <3 months lifetime exposure over ago (non-Li group) 50 healthy...