A5057490419- Birth, Development, and Health
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Stress Responses and Cortisol
- Advanced MRI Techniques and Applications
- Gestational Diabetes Research and Management
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Neuroscience of respiration and sleep
- Child and Adolescent Psychosocial and Emotional Development
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Genomic variations and chromosomal abnormalities
- Schizophrenia research and treatment
- Medical Imaging and Analysis
- Adipose Tissue and Metabolism
- Iron Metabolism and Disorders
- Folate and B Vitamins Research
- Child Abuse and Trauma
- Medical Imaging Techniques and Applications
University of California, Irvine
2016-2025
University of Minnesota
2023
McLean Hospital
2023
Wadsworth Atheneum Museum of Art
2018
UC Irvine Health
2011-2018
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018
Humboldt-Universität zu Berlin
2018
Freie Universität Berlin
2018
Pediatrics and Genetics
2016
University of Southern California
2015
The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades research using scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed MRI scans from 2028 patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical volumes that differentiated ranked them according their effect sizes. Compared had smaller hippocampus (Cohen's...
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying sources of can help generate novel clinical hypotheses etiology assist in development biomarkers for indexing disease progression prognosis. Here we were interested case-control differences intracranial volume (ICV) each eight subcortical measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a...
The first year of life is an important period for emergence fear in humans. While animal models have revealed developmental changes amygdala circuitry accompanying emerging fear, human neural systems involved early development remain poorly understood. To increase understanding the foundations it to consider parallel cognitive development, which may modulate associations between typical and subsequent risk fear-related psychopathology. We, therefore, examined functional connectivity with...
Abstract The human brain grows quickly during infancy and early childhood, but factors influencing maturation in this period remain poorly understood. To address gap, we harmonized data from eight diverse cohorts, creating one of the largest pediatric neuroimaging datasets to date focused on birth 6 years age. We mapped developmental trajectory intracranial subcortical volumes ∼2,000 children studied how sociodemographic adverse outcomes influence structure cognition. amygdala was first...
Abstract Purpose To use functional MRI (fMRI) methods to visualize a network of auditory and language‐processing brain regions associated with processing an aurally‐presented story. We compare passive listening (PL) story paradigm active‐response (AR) version including online performance monitoring sparse acquisition technique. Materials Methods Twenty children (ages 11–13 years) completed PL AR tasks. The presented alternating 30‐second blocks stories tones; the segments, comprehension...
There is a major resurgence of interest in brown adipose tissue (BAT) biology, particularly regarding its determinants and consequences newborns infants. Reliable methods for non-invasive BAT measurement human infants have yet to be demonstrated. The current study first validates quantitative imaging rodents post mortem followed by excision re-imaging excised tissues. Identical are then employed cohort vivo establish the reliability these measures provide normative statistics depot volume...
Connectivity between the amygdala, insula (Amygdala-aI) and ventral medial prefrontal cortex (Amygdala-vmPFC) have been implicated in individual variability fear vulnerability to psychiatric disorders. However, it is currently unknown what extent connectivity these regions newborn period relevant for development of other aspects negative emotionality (NE), such as sadness. Here, we investigate Am-Ins Am-vmPFC resting state functional relation developmental trajectories sadness over first two...
Maternal psychosocial stress during pregnancy can impact the developing fetal brain and influence offspring mental health. In this context, animal studies have identified hippocampus amygdala as key regions of interest, however, evidence in humans is sparse. We, therefore, examined associations between maternal prenatal stress, newborn hippocampal volumes, child social-emotional development. a sample 86 mother-child dyads, perceived was assessed serially early, mid late pregnancy. Following...
Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little known about how heterogeneity of trajectories affect brain systems and behavioral phenotypes infancy. This study was designed to address this gap knowledge.
Abstract Background Maternal pre-pregnancy obesity may negatively affect offspring outcomes, including neurodevelopment. This study examined the relationship between maternal body mass index (MBMI) and microstructure of hippocampus amygdala in neonates. Methods Diffusion tensor imaging was used to assess mean diffusivity (MD) these brain regions 122 infants (mean gestational age: 39.9 weeks, age at scan: 24.8 days) from FinnBrain Birth Cohort Study ( www.finnbrain.fi ). Linear regression...
Importance: Maternal diabetes (MD) and maternal obesity (MO) have been robustly established to confer health risks in offspring. Additionally, mounting evidence suggests that these fetal programming effects vary by sex, but whether factors independently or interactively influence infant brain development remains unclear. Objectives: To characterize interactions between MD, MO, sex on offspring subcortical volumes. Design, setting participants: This was a cross-sectional study of 1,966...
Glucocorticoids play a key role during intrauterine development in cellular growth and differentiation. Evidence suggests that exposure to inappropriate concentrations of glucocorticoids sensitive developmental periods may produce alterations physiological systems impact obesity risk. To elucidate the magnitude stage-of-gestation–specific association maternal cortisol pregnancy with infant adiposity. Sixty-seven mother–child dyads recruited early at university-based obstetric clinics...