A5052438867- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Family and Disability Support Research
- Genomic variations and chromosomal abnormalities
- Child Development and Digital Technology
- Advanced Neuroimaging Techniques and Applications
- Congenital heart defects research
- Fetal and Pediatric Neurological Disorders
- Child Nutrition and Feeding Issues
- Neonatal and fetal brain pathology
- Virology and Viral Diseases
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Language Development and Disorders
- Obsessive-Compulsive Spectrum Disorders
- Infant Development and Preterm Care
- Medical Image Segmentation Techniques
- Advanced MRI Techniques and Applications
- Behavioral and Psychological Studies
- Genomics and Rare Diseases
- Cell Image Analysis Techniques
- Morphological variations and asymmetry
- Child and Animal Learning Development
- Child and Adolescent Psychosocial and Emotional Development
- Resilience and Mental Health
University of North Carolina at Chapel Hill
2016-2025
University of North Carolina Health Care
2022-2024
Carolina Institute for NanoMedicine
2014-2024
Cohort (United Kingdom)
2024
University of Utah
1995-2024
University of California, Davis
2024
University of North Carolina at Charlotte
2023
Outcomes Research Consortium
2023
Health Outcomes Solutions (United States)
2023
Mallinckrodt (United States)
2012-2022
Several lines of evidence point to genetic involvement in autism spectrum disorders (ASDs), neurodevelopmental and neuropsychiatric characterized by impaired verbal communication social interaction. The clinical complexities the condition make it difficult identify susceptibility factors, but two related studies now present robust for a involvement. first, genome-wide association study, identifies six single-nucleotide polymorphisms strongly associated with autism. These variants lie between...
Mouse models of social dysfunction, designed to investigate the complex genetics behaviors, require an objective methodology for scoring interactions relevant human disease symptoms. Here we describe automated, three chambered apparatus monitor interaction in mouse. Time spent each chamber and number entries are scored automatically by a system detecting photocell beam breaks. When tested with automated equipment, juvenile male C57BL/6J mice more time containing stranger mouse than empty...
While the neuroanatomical basis of autism is not yet known, evidence suggests that brain enlargement may be characteristic this disorder. Inferences about timing have recently come from studies head circumference (HC).To examine volume and HC in individuals with as compared control individuals.A cross-sectional study was conducted at first time point an ongoing longitudinal magnetic resonance imaging development autism. Retrospective measurements were gathered medical records on a larger...
Children who developed autism spectrum disorders (ASDs) by age 2 had greater development of cerebral white matter fiber tracts 6 months than unaffected children. After the initial accelerated development, children ASDs slower so that their was less in
Autism has been thought to be characterized, in part, by dysfunction emotional and social cognition, but the pathology of underlying processes their neural substrates remain poorly understood. Several studies have hypothesized that abnormal amygdala function may account for some impairments seen autism, specifically, impaired recognition socially relevant information from faces. We explored this issue eight high-functioning subjects with autism four experiments assessed information,...
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known risk has been traced to rare variants, principally copy number variants (CNVs). To identify common variation, Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes association with ASD. In one four primary analyses, signal marker rs4141463, located within MACROD2, crossed genome-wide...
<h3>Context</h3> Brain enlargement has been observed in 2-year-old children with autism, but the underlying mechanisms are unknown. <h3>Objective</h3> To investigate early growth trajectories brain volume and cortical thickness. <h3>Design</h3> Longitudinal magnetic resonance imaging study. <h3>Setting</h3> Academic medical centers. <h3>Participants</h3> Fifty-nine autism spectrum disorder (ASD) 38 control children. <h3>Intervention</h3> Children were examined at approximately 2 years of...
This study was undertaken to obtain detailed measurements of the volume brain, using magnetic resonance imaging (MRI), in a carefully selected group autistic subjects and comparison subjects.Twenty-two male 20 volunteer were examined with (1.5-mm slices) MRI throughout entire brain. Total total brain tissue, lateral ventricle volumes measured by manual tracing automated techniques.After height performance IQ controlled, had significantly greater than subjects.These findings suggest that have...
To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics infants at high familial risk for ASD (HR), and low (LR). Participants included 210 HR 98 LR across 4 sites with comparable behavioral data age 6, 12, 24 months assessed in domains cognitive development (Mullen Scales Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), features (Autism Observation Scale Infants). evaluated according to...
Functional brain imaging of 6-month-old infants with a high familial risk for autism predicts diagnosis at 24 months age.
Background: Restricted repetitive behaviors (RRBs) are a core feature of autism and consist variety behaviors, ranging from motor stereotypies to complex circumscribed interests. The objective the current study was examine structure RRBs in using relevant items Autism Diagnostic Interview‐Revised sample 316 individuals with autistic disorder. Methods/Results: Using exploratory factor analysis, three distinct factors were identified: Repetitive Motor Behaviors (RMB), Insistence on Sameness...
This study examined the frequency of personality, language, and social-behavioral characteristics believed to comprise broad autism phenotype (BAP), across families differing in genetic liability autism. We hypothesized that within this unique sample comprised multiple-incidence (MIAF), single-incidence (SIAF), control Down syndrome (DWNS), a graded expression would be observed for principal conferring susceptibility autism, which such features express most profoundly among parents from...
Context: Multiple articles describe a constellation of language, personality, and social-behavioral features present in relatives that mirror the symptom domains autism, but are much milder expression.Studies this broad autism phenotype (BAP) may provide potentially important complementary approach for detecting genes causing defining associated neural circuitry by identifying more refined phenotypes can be measured quantitatively both affected unaffected individuals tied to functioning...
Objective-The authors sought to determine whether specific patterns of oculomotor functioning and visual orienting characterize 7-month-old infants who later meet criteria for an autism spectrum disorder (ASD) identify the neural correlates these behaviors.Method-Data were collected from 97 infants, whom 16 high-familial-risk classified as having ASD, 40 did not ASD (high-risk negative), 41 low-risk infants.All underwent eye-tracking task at a mean age 7 months clinical assessment 25...