Gillian Baird
A5067210442- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Language Development and Disorders
- Child Development and Digital Technology
- Attention Deficit Hyperactivity Disorder
- Genomic variations and chromosomal abnormalities
- Child and Adolescent Health
- Reading and Literacy Development
- Infant Development and Preterm Care
- Cerebral Palsy and Movement Disorders
- Behavioral and Psychological Studies
- Child and Adolescent Psychosocial and Emotional Development
- Child and Animal Learning Development
- Hip disorders and treatments
- Virology and Viral Diseases
- Obsessive-Compulsive Spectrum Disorders
- Children's Physical and Motor Development
- Epilepsy research and treatment
- Adolescent and Pediatric Healthcare
- Neuroscience and Neuropharmacology Research
- Assistive Technology in Communication and Mobility
- Genomics and Rare Diseases
- Congenital heart defects research
Guy's and St Thomas' NHS Foundation Trust
2015-2024
Evelina London Children's Healthcare
2011-2024
Kings Health Partners
2013-2022
St Thomas' Hospital
2000-2021
Center for Neurosciences
2018-2021
Yale University
2018
University of British Columbia
2018
University of California, San Francisco
2018
Hussman Institute for Autism
2018
University of California, Los Angeles
2018
Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed excess genic deletions duplications in affected versus control groups (1.41-fold, p = 1.0 × 10(-5)) increase subjects carrying exonic pathogenic CNVs overlapping known loci associated with dominant or X-linked ASD intellectual disability (odds ratio 12.62, 2.7 10(-15), ∼3% subjects). Pathogenic CNVs, often showing variable expressivity,...
Background Diagnosis of ‘specific’ language impairment traditionally required nonverbal IQ to be within normal limits, often resulting in restricted access clinical services for children with lower NVIQ . Changes DSM ‐5 criteria disorder removed this requirement. This study sought delineate the impact varying on prevalence, presentation and functional first UK population at school entry. Methods A population‐based survey design sample weighting procedures was used estimate prevalence. We...
We undertook this study to explore the degree of impairment in movement skills children with autistic spectrum disorders (ASD) and a wide IQ range.Movement were measured using Movement Assessment Battery for Children (M-ABC) large, well defined, population-derived group (n=101: 89 males,12 females; mean age 11y 4mo, SD 10mo; range 10y-14y 3mo) childhood autism broader ASD scores. Additionally, we tested whether parent-completed questionnaire, Developmental Coordination Disorder Questionnaire...
Background Investigation to see if there are key psychological risk indicators for autism in a random population study of children at 18 months age; and assess how well these discriminate who receive diagnosis from other forms developmental delay. Method Sixteen thousand the southeast England were screened by their health visitor or GP, during routine 18-month-old check-up, using CHAT (Checklist Autism Toddlers). From previous high-risk we predicted that age failed three items...
Systematic studies of infants with autism have not been previously carried out. Taking advantage a new prospective screening instrument for in infancy (S. Baron-Cohen et al., 1996), the present study found that, compared developmentally delayed and normally developing children, 20-month-old children were specifically impaired on some aspects empathy, joint attention, imitation. Infants failed to use social gaze empathy attention tasks. Both developmental delay demonstrated functional play,...
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known risk has been traced to rare variants, principally copy number variants (CNVs). To identify common variation, Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes association with ASD. In one four primary analyses, signal marker rs4141463, located within MACROD2, crossed genome-wide...
Background Autism spectrum disorder (ASD) was once considered to be highly associated with intellectual disability and show a characteristic IQ profile, strengths in performance over verbal abilities distinctive pattern of ‘peaks’ ‘troughs’ at the subtest level. However, there are few data from epidemiological studies. Method Comprehensive clinical assessments were conducted 156 children aged 10–14 years [mean ( s.d .)=11.7 (0.9)], seen as part an study (81 childhood autism, 75 other ASD). A...
Autism is characterized by impairments in reciprocal social interaction and communication, restricted stereotyped patterns of interests activities. Developmental difficulties are apparent before 3 years age there evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search loci autism was performed on 87 affected sib pairs plus 12 non-sib relative-pairs, from a total 99 families identified an international consortium. Regions six...
To examine longitudinal associations between diagnosis, joint attention, play and imitation abilities language outcome in infants with autism pervasive developmental disorder.Experimental measures of were conducted a sample spectrum disorder at age 20 months. Language was assessed 42 A within-group correlational design adopted.Language months higher for children diagnosis than autism. follow-up also positively associated performance on experimental attention imitation, but not 'goal...
Objective: To examine the predictive validity of symptom severity, cognitive and language measures taken at ages 2 3 years to outcome age 7 in a sample children diagnosed with autism 2. Method: Twenty‐six were re‐assessed years. At each assessments completed. Results: The pattern autistic severity varied over time by domain. Across time, moved across diagnostic boundaries both terms clinical diagnosis instrument on Autism Diagnostic Interview‐Revised (ADI‐R). On all group variability scores...
The association between, and stability of, clinical diagnosis derived from the Autism Diagnostic Interview‐Revised (ADI‐R; Lord, Rutter, & Le Couteur, 1994) was examined in a sample of prospectively identified children with childhood autism other pervasive developmental disorders assessed at age 20 months 42 months. Clinical stable, all diagnosed receiving or related disorder (PDD) also reasonably sensitive, who went on to receive being as having PDD However, for Asperger's syndrome...
Parent report data on early language development measured using the MacArthur Communicative Development Inventory (CDI-Infant Form) was collected 134 preschool children with autism spectrum disorder. The pattern of understanding phrases, word comprehension and expression, production gestures, compared to typical pattern. In common there considerable variability in acquisition, although for group as a whole this significantly delayed normal course. addition, atypical patterns were identified...
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), contribution common to risk developing ASD less clear.To produce a more comprehensive picture, we report Stage 2 Autism Genome Project genome-wide association study, adding 1301 families and bringing total 2705 analysed (Stages 1 2).In addition evaluating individual single nucleotide polymorphisms (SNPs), also sought evidence variants, en masse, might affect...