A5008296740- Autism Spectrum Disorder Research
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Child Development and Digital Technology
- Genetics and Neurodevelopmental Disorders
- Infant Development and Preterm Care
- Family and Disability Support Research
- Child and Animal Learning Development
- Fetal and Pediatric Neurological Disorders
- Language Development and Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Infant Nutrition and Health
- Attention Deficit Hyperactivity Disorder
- Child Nutrition and Feeding Issues
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Behavioral and Psychological Studies
- Early Childhood Education and Development
- Health, Environment, Cognitive Aging
- Face Recognition and Perception
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Virology and Viral Diseases
University of Minnesota
2016-2025
University of Minnesota Medical Center
2018-2025
University of Minnesota System
2017-2025
Allen Institute for Brain Science
2023-2024
Center for Autism and Related Disorders
2013-2024
Children's Hospital of Philadelphia
2012-2024
Industrial Control Design (Norway)
2024
Brain (Germany)
2023
Mallinckrodt (United States)
2012-2022
University of North Carolina at Chapel Hill
2010-2022
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of human brain. However, no reference standards currently exist to quantify individual differences metrics over time, contrast growth charts for anthropometric traits such as height weight
Children who developed autism spectrum disorders (ASDs) by age 2 had greater development of cerebral white matter fiber tracts 6 months than unaffected children. After the initial accelerated development, children ASDs slower so that their was less in
To delineate the early progression of autism spectrum disorder (ASD) symptoms, this study investigated developmental characteristics infants at high familial risk for ASD (HR), and low (LR). Participants included 210 HR 98 LR across 4 sites with comparable behavioral data age 6, 12, 24 months assessed in domains cognitive development (Mullen Scales Early Learning), adaptive skills (Vineland Adaptive Behavioral Scales), features (Autism Observation Scale Infants). evaluated according to...
Functional brain imaging of 6-month-old infants with a high familial risk for autism predicts diagnosis at 24 months age.
Objective-The authors sought to determine whether specific patterns of oculomotor functioning and visual orienting characterize 7-month-old infants who later meet criteria for an autism spectrum disorder (ASD) identify the neural correlates these behaviors.Method-Data were collected from 97 infants, whom 16 high-familial-risk classified as having ASD, 40 did not ASD (high-risk negative), 41 low-risk infants.All underwent eye-tracking task at a mean age 7 months clinical assessment 25...
Numerous brain imaging studies indicate that the corpus callosum is smaller in older children and adults with autism spectrum disorder. However, there are no published examining morphological development of this connective pathway infants at-risk for Magnetic resonance data were collected from 270 at high familial risk disorder 108 low-risk controls 6, 12 24 months age, 83% contributing two or more points. Fifty-seven met criteria ASD based on clinical-best estimate diagnosis age 2 years....
Background Recent evidence suggests that restricted and repetitive behaviors may differentiate children who develop autism spectrum disorder ( ASD ) by late infancy. How these core symptoms manifest early in life, particularly among infants at high risk for the disorder, is not well characterized. Methods Prospective, longitudinal parent‐report data (Repetitive Behavior Scales‐Revised) were collected 190 high‐risk toddlers 60 low‐risk controls from 12 to 24 months of age. Forty‐one...
Infancy and early childhood are periods of rapid brain development, during which structure function mature alongside evolving cognitive ability. An important neurodevelopmental process this postnatal period is the maturation myelinated white matter, facilitates communication across neural systems networks. Though prior imaging studies in children (4 years age above), adolescents, adults have consistently linked matter development with intelligence, few examined how these processes related...
Abstract Initiating joint attention (IJA), the behavioral instigation of coordinated focus 2 people on an object, emerges over first years life and supports social-communicative functioning related to healthy development aspects language, empathy, theory mind. Deficits in IJA provide strong early indicators for autism spectrum disorder, therapies targeting have shown tremendous promise. However, brain systems underlying childhood are poorly understood, due part significant methodological...
Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli. To date, little is known about the neural circuitry underlying these ASD early in life.Longitudinal diffusion tensor imaging data were collected from 217 infants at high familial risk ASD. Forty-four diagnosed with age 2. Targeted cortical, cerebellar, striatal white matter pathways...
Existing evidence suggests executive functioning (EF) deficits may be present in children with autism spectrum disorder (ASD) by 3 years of age. It is less clear when, prior to years, EF emerge and how unfold over time. The contribution motor skill difficulties poorer ASD has not been systematically studied. We investigated the developmental trajectory infants at high low familial risk for (HR & LR) potential associations between skills, diagnostic group, performance. Participants included...
Sleep patterns in children with autism spectrum disorder (ASD) appear to diverge from typical development the second or third year of life. Little is known, however, about occurrence sleep problems infants who later develop ASD and possible effects on early brain development. In a longitudinal neuroimaging study at familial high low risk for ASD, parent-reported onset were examined relation subcortical volumes first 2 years life.A total 432 included across three groups: developed (N=71), did...
Objective: Previous research has demonstrated that the amygdala is enlarged in children with autism spectrum disorder (ASD). However, precise onset of this enlargement during infancy, how it relates to later diagnostic behaviors, whether timing infancy specific amygdala, and ASD (or present other neurodevelopmental disorders, such as fragile X syndrome) are all unknown. Methods: Longitudinal MRIs were acquired at 6–24 months age 29 infants syndrome, 58 high likelihood for who diagnosed ASD,...
Features of autism spectrum disorder, attention‐deficit/hyperactivity learning disorders, intellectual disabilities, and communication motor disorders usually emerge early in life are associated with atypical neurodevelopment. These “neurodevelopmental conditions” grouped together the DSM‐5 ICD‐11 to reflect their shared characteristics. Yet, reliance on categorical diagnoses poses significant challenges both research clinical settings (e.g., high co‐occurrence, arbitrary diagnostic...