A5056242781- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Mental Health Research Topics
- Ethics and Legal Issues in Pediatric Healthcare
- Functional Brain Connectivity Studies
- Neuroethics, Human Enhancement, Biomedical Innovations
- Biomedical Ethics and Regulation
- Child Nutrition and Feeding Issues
- Genomics and Rare Diseases
- Mental Health and Psychiatry
- Reproductive Health and Technologies
- Infant Development and Preterm Care
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Ethics in medical practice
- Ethics in Clinical Research
- Prenatal Substance Exposure Effects
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Healthcare Decision-Making and Restraints
- HIV-related health complications and treatments
- Pregnancy and Medication Impact
- Environmental Justice and Health Disparities
University of Washington
2018-2025
Seattle Children's Hospital
2019-2025
Seattle University
2021
Center for Autism and Related Disorders
2019-2020
Temple University
2020
Imaging Center
2020
Children's Hospital of Philadelphia
2020
Duke University
2012-2018
University of Michigan
2010
This review describes the effects of intervention for young children with autism spectrum disorder (ASD) on parents. Like all children, ASD bring both negative and positive experiences parents families-from increased resource needs, to higher levels parenting-related stress, personal growth family members. It is increasingly recognized that, although are primary targets early intervention, also impacts From time emerging developmental concerns begin be identified, through process obtaining a...
Sleep patterns in children with autism spectrum disorder (ASD) appear to diverge from typical development the second or third year of life. Little is known, however, about occurrence sleep problems infants who later develop ASD and possible effects on early brain development. In a longitudinal neuroimaging study at familial high low risk for ASD, parent-reported onset were examined relation subcortical volumes first 2 years life.A total 432 included across three groups: developed (N=71), did...
To benefit from cognitive behavioral therapy (CBT), individuals must not only learn new skills but also strategically implement them outside of session. Here, we tested a novel technique for personalizing CBT and facilitating their generalization to daily life. We hypothesized that showing participants the impact specific strategies on own brain function using real-time functional magnetic imaging (rt-fMRI) neurofeedback would increase metacognitive awareness, help identify effective...
Stigma against patients with functional neurological disorder (FND) presents obstacles to diagnosis, treatment, and research. The lack of biomarkers the potential for symptoms be misunderstood, invalidated, or dismissed can leave patients, families, healthcare professionals at a loss. exacerbates suffering unmet needs result in poor clinical management prolonged, repetitive use resources. Our current understanding stigma FND comes from surveys documenting frustration experienced by providers...
Emerging evidence suggests parenting supports implemented in the first 2 years of life may influence developmental outcomes for infants more likely to be Autistic. Yet questions remain about acceptability these Autistic and autism communities. Through mixed-methods participatory research – co-designed produced by non-Autistic researchers we sought diverse community perspectives on this topic, including understand relative different support options. A total 238 participants completed our...
Debates about the ethics of human brain organoids have proceeded without input individuals whose brains are being modeled. Interviews with donors biospecimens for organoid research revealed overall enthusiasm as a tool biomedical discovery, alongside desire ongoing engagement teams to learn results research, allow transfer decision-making authority over time, and ensure ethical boundaries not crossed. Future work is needed determine most feasible resource-efficient way longitudinally engage...
Novelty detection, a critical computation within the medial temporal lobe (MTL) memory system, necessarily depends on prior experience. The current study used functional magnetic resonance imaging (fMRI) in humans to investigate dynamic changes MTL activation and connectivity as experience with novelty accumulates. fMRI data were collected during target detection task: Participants monitored series of trial-unique novel familiar scene images detect repeating scene. Even though themselves did...
This study measured distortions of memory during short-term (STM) and long-term (LTM) versions a semantically associated word list learning paradigm. Performance patients with mild-to-moderate Alzheimer's disease (AD; MMSE ≥16) was compared performance age-matched, healthy older adult participants.
This study examined the effects of HIV infection, methamphetamine dependence and their interaction on cortical thickness, area volume, as well potential interactive morphometry with age. T1-weighted structural images were obtained a 3.0T General Electric MR750 scanner. Freesurfer v5.3.0 was used to derive volume measures in thirty-four regions based Desikan-Killiany atlas labels. Following correction for multiple statistical tests, diagnosis not significantly related thickness or any ROI,...
Auto-biological beliefs-beliefs about one's own biology-are an understudied component of personal identity. Research participants who are led to believe they biologically vulnerable affective disorders report more symptoms and less ability control their mood; however, little is known the impact self-originating beliefs risk for psychopathology, whether such correspond empirically derived estimates actual vulnerability. Participants in a neuroimaging study (n = 1256) completed self-report...
Neurotechnologies are rapidly being developed with the aim of alleviating suffering caused by disease and assisting individuals various disabilities. As capabilities applications neural devices advance, potential ethical challenges related to agency, identity, privacy, equality, normality justice have been noted. We sought explore attitudes toward these in two important, but understudied groups stakeholders—members device industry members general public. Survey responses from 66...
Psychotherapy is a complex, multilayered process with the potential to bring about changes at multiple levels of functioning, from neurobiology brain individual's role in social world. Although studies mechanisms by which psychotherapy leads change continue appear, there remains much be learned how psychological interventions work. To guide explorations and for whom particular treatment approaches lead change, researchers can rely on theory identify loci translational research methods...
As knowledge of the neurobiological basis psychopathology has advanced, public perceptions have shifted toward conceptualizing mental disorders as biology. However, little is known about how patients respond to biological information their own disorders. We refer such auto-biological—describing our systems a component identity. Drawing on research from attribution theory, we explore potential for auto-biological shape view themselves in relation propose an attributional framework presenting...
Predictive testing for familial disorders can guide healthcare and reproductive decisions. Familial with onset in childhood (e.g., autism spectrum disorder [ASD]) are promising targets presymptomatic prediction; however, little is known about parent perceptions of risk to their children the period. The current study examined parents infants at high ASD enrolled a longitudinal brain behavior development.Semistructured interviews were conducted 37 high-risk during window (3-15 months) that...
Justice is a core principle in bioethics, and fair opportunity to achieve health central this principle. Racism other forms of prejudice, discrimination, or bias directed against people on the basis their membership particular racial ethnic group are known contributors inequity, defined as unjust differences access care. Though hospital-based ethics committees consultation services routinely address issues justice that arise course patient care, there variability whether how racism causes...
Understanding dreams has long been considered fundamental to the development of a theory consciousness. Evidence from neurobiology and neuroimaging research paved way for new theories dreaming that are empirically supported. In this article we argue is unique state consciousness incorporates 3 temporal dimensions: experience present, processing past, preparation future. The complexity made possible in part by neurobiological environment sleep, which stimuli internally generated many...
Universal screening for autism spectrum disorder (ASD) is recommended during pediatric primary care visits in the first 2 years of life. However, many children are missed by initial and not diagnosed with ASD until later. Research efforts underway to develop evaluate new objective measures risk that can be used infancy, before symptoms emerge. Initial studies these tests, particularly MRI-based infants at high familial risk, have shown promise but yet been evaluated clinical trials. We...
Research using human fetal tissue has saved millions of lives through vaccines and other advances, but was markedly restricted by federal regulations in 2019. Although the restrictions were partially reversed 2021, additional regulatory changes are needed to prevent further damage essential research programs while preserving protection for subjects.
A central tension in pediatric research ethics arises from our desire to protect children harm while also allowing progress toward discoveries that could improve child health. prime example of this is on a controversial yet increasingly common practice: the use cannabis by women treat nausea and vomiting pregnancy. Studies pregnancy face combination ethical hurdles because inclusion pregnant involvement schedule I controlled substance. Given growing need for safety efficacy pregnancy, we...