A5010009874- Neuroethics, Human Enhancement, Biomedical Innovations
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Mental Health and Psychiatry
- Neuroscience and Neuropharmacology Research
- Pain Management and Placebo Effect
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neuroscience, Education and Cognitive Function
- Neurogenesis and neuroplasticity mechanisms
- Biomedical Ethics and Regulation
- Psychology of Moral and Emotional Judgment
- Glioma Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- Artificial Intelligence in Healthcare and Education
- Mental Health Treatment and Access
- Neurology and Historical Studies
- Histone Deacetylase Inhibitors Research
- Biomedical and Engineering Education
- Nerve injury and regeneration
- Child and Adolescent Psychosocial and Emotional Development
Emory University
2014-2023
Neurotech (United States)
2021-2023
Ethics and Public Policy Center
2020-2021
Emory National Primate Research Center
2011
Although Parkinson's disease (PD) is characterized primarily by loss of nigrostriatal dopaminergic neurons, there a concomitant norepinephrine (NE) neurons in the locus coeruleus. Dopaminergic lesions induced 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are commonly used to model PD, and although MPTP effectively mimics neuropathology PD mice, it fails produce PD-like motor deficits. We hypothesized that unable recapitulate abnormalities either because behavioral paradigms measure...
The basal ganglia are comprised of the striatum, external and internal segment globus pallidus (GPe GPi, respectively), subthalamic nucleus (STN), substantia nigra pars compacta reticulata (SNc SNr, respectively). Dopamine has long been identified as an important modulator function in disturbances striatal dopaminergic transmission have implicated diseases such Parkinson's disease (PD), addiction attention deficit hyperactivity disorder. However, recent evidence suggests that dopamine may...
Developing more and better diagnostic therapeutic tools for central nervous system disorders is an ethical imperative. Human research with neural devices important to this effort a critical focus of the National Institutes Health Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Despite regulations standard practices conducting research, researchers others seek guidance on how ethically conduct device studies. This article draws on, reviews, specifies,...
Neuroscience presents important neuroethical considerations. Human neuroscience demands focused application of the core research ethics guidelines set out in documents such as Belmont Report. Various mechanisms, including institutional review boards (IRBs), privacy rules, and Food Drug
Smaller, more affordable, and portable MRI brain scanners offer exciting opportunities to address unmet research needs long-standing health inequities in remote resource-limited international settings. Field-based neuroimaging low- middle-income countries (LMICs) can improve local capacity conduct both structural functional neuroscience studies, expand knowledge of injury neuropsychiatric neurodevelopmental disorders, ultimately the timeliness quality clinical diagnosis treatment around...
Abstract Researchers are rapidly developing and deploying highly portable MRI technology to conduct field-based research. The new will widen access include investigators in remote unconventional settings facilitate greater inclusion of rural, economically disadvantaged, historically underrepresented populations. To address the ethical, legal, societal issues raised by accessible MRI, an interdisciplinary Working Group (WG) engaged a multi-year structured process analysis consensus building,...
OPINION article Front. Neuroeng., 12 February 2014 Volume 7 - | https://doi.org/10.3389/fneng.2014.00004
On October 9 and 10, 2015, a conference entitled “Controversial labels clinical uncertainties: psychogenic disorders, conversion disorder, functional symptoms” was held at the Center for Ethics, Emory University, Atlanta, GA. This brought together select group of 30 distinguished thought leaders practitioners– including ethicists, researchers, clinicians, humanities scholars, advocates to discuss unique challenges controversies related diagnosis, treatment, stigma patients with what is...
Stigma against patients with functional neurological disorder (FND) presents obstacles to diagnosis, treatment, and research. The lack of biomarkers the potential for symptoms be misunderstood, invalidated, or dismissed can leave patients, families, healthcare professionals at a loss. exacerbates suffering unmet needs result in poor clinical management prolonged, repetitive use resources. Our current understanding stigma FND comes from surveys documenting frustration experienced by providers...
Abstract Innovations in neurotechnologies have ignited conversations about ethics around the world, with implications for researchers, policymakers, and private sector. The human rights impacts of drawn attention United Nations bodies; nearly 40 states are tasked implementing Organization Economic Co-operation Development’s principles responsible innovation neurotechnology; States is considering placing export controls on brain-computer interfaces. Against this backdrop, we offer first...
The subthalamic nucleus (STN) receives a dopaminergic innervation from the substantia nigra pars compacta, but role of this projection remains poorly understood, particularly in primates. To address issue, we used immuno-electron microscopy to localize D1, D2, and D5 dopamine receptors STN rhesus macaques studied electrophysiological effects activating D1-like or D2-like normal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian monkeys. Labeling D1 D2 was primarily...
The Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is focused on developing new tools and neurotechnologies to revolutionize our understanding of how the brain functions in health disease, large part address growing societal impact neurological, mental health, substance use disorders. Recent advances neurotechnology are delivering unprecedented ways interrogate modulate function, BRAIN translation for human medical uses over next decade. Since its...
<h3>SUMMARY:</h3> With rapid advances in neuroimaging technology, there is growing concern over potential misuse of neuroradiologic imaging data legal matters. On December 7 and 8, 2012, a multidisciplinary consensus conference, Use Abuse Neuroimaging the Courtroom, was held at Emory University Atlanta, Georgia. Through this interactive forum, highly select group experts—including neuroradiologists, neurologists, forensic psychiatrists, neuropsychologists, neuroscientists, scholars,...
According to traditional models of the basal ganglia-thalamocortical network connections, dopamine exerts D2-like receptor (D2LR)-mediated effects through actions on striatal neurons that give rise "indirect" pathway, secondarily affecting activity in internal and external pallidal segments (GPi GPe, respectively) substantia nigra pars reticulata (SNr). However, accumulating evidence from rodent literature suggests D2LR activation also directly influences synaptic transmission these nuclei....
Enhanced adult hippocampal neurogenesis and increased trophic factor expression mediate the behavioral effects of antidepressants. We investigated influence alpha2‐adrenoceptors on neurogenesis. found that alpha2 agonists selectively decrease progenitor proliferation. These persist in Dbh−/− mice lacking norepinephrine, suggesting an action through alpha2‐heteroceptors. Adult progenitors express all alpha2‐adrenoceptor subtypes, decreased neurosphere frequency BrdU incorporation indicate...