Paul Tuite
A5065276053- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Lysosomal Storage Disorders Research
- RNA regulation and disease
- Balance, Gait, and Falls Prevention
- Nuclear Receptors and Signaling
- Neurological diseases and metabolism
- Hereditary Neurological Disorders
- Motor Control and Adaptation
- Vestibular and auditory disorders
- Alzheimer's disease research and treatments
- Autoimmune Neurological Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Studies on Chitinases and Chitosanases
- Glycogen Storage Diseases and Myoclonus
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Artificial Intelligence in Healthcare and Education
University of Minnesota
2015-2025
University of Minnesota Medical Center
2003-2022
University of Minnesota System
2003-2022
Columbus Oncology and Hematology Associates
2018
University of Florida
2018
National Institutes of Health
2013
Cornell University
2013
Brown University
2011
Twin Cities Orthopedics
2008
University Medical Center
2003-2005
Abstract Pharmacologic treatment for essential tremor and the of Parkinson's disease is often inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We performed a multicenter trial unilateral high‐frequency stimulation ventral intermedius nucleus thalamus in 29 patients with 24 disease, using blinded assessment at 3 months after surgery to compare clinical rating ON OFF baseline 1‐year follow‐up. Six were not implanted because lack intraoperative suppression...
Abstract Objective Based on new understanding of nondopaminergic pathways involved in Parkinson's disease (PD) pathophysiology, a selective adenosine A 2A receptor antagonist, istradefylline, shows promise for the treatment PD. Methods Istradefylline (40mg/day) was studied levodopa‐treated PD subjects experiencing prominent wearing‐off motor fluctuations. At 23 North American sites, 196 were randomized double‐blind, 12‐week outpatient clinical trial istradefylline (114 completing trial) or...
Precise knowledge about limb position and orientation is essential for the ability of nervous system to plan control voluntary movement. While it well established that proprioceptive signals from peripheral receptors are necessary sensing motion, less clear which supraspinal structures mediate ultimately lead conscious awareness (kinaesthesia). Recent functional imaging studies have revealed cerebellum, but not basal ganglia, involved in sensory processing information induced by passive...
Abstract Paraneoplastic chorea is described in 16 patients: 11 with limited small‐cell carcinoma, 2 lung cancer revealed by imaging, 1 renal cell and lymphoma. All had CRMP‐5‐IgG; 6 also ANNA‐1 (anti‐Hu), including without evident cancer. Chorea was the initial most prominent symptom patients, asymmetric or unilateral 5 part of a multifocal syndrome 14 patients. Basal ganglia abnormalities were magnetic resonance imaging at autopsy (as perivascular inflammation microglial activation). Four...
The vast majority of the parkin mutations previously identified have been found in individuals with juvenile or early onset PD. Previous screening later PD cohorts has not substantial numbers mutations. Families at least two siblings were ascertained to identify genes contributing susceptibility. Screening gene, by both quantitative PCR and exon sequencing, was performed those families either (age < =50 years) positive lod score a marker intron 7 gene. A total 25 different gene 103 from 47...
<b>BACKGROUND AND PURPOSE:</b> Parkinson disease (PD) is characterized by basal ganglia abnormalities. However, there are neurodegenerative changes in PD that extend beyond the and not sufficiently evaluated with standard MR imaging. The aim of this study was to characterize whole-brain gray matter (GM) white (WM) using diffusion tensor imaging (DTI). <b>MATERIALS METHODS:</b> Thirteen control 12 subjects nondemented were examined DTI 3D anatomic T1-weighted images. Statistical parametric...
Objective This study aimed to determine if the antioxidant N-acetylcysteine (NAC) is able alter peripheral and central redox capabilities in patients with Parkinson disease (PD) or Gaucher (GD). Methods The included nondemented adult subjects: 3 PD, GD, healthy controls. Baseline brain glutathione (GSH) concentrations were measured using 7-T magnetic resonance spectroscopy (MRS). blood reduced-to-oxidized GSH ratios determined for each subject. Brain then during at specified time points...
Background Parkinson disease (PD) is characterized by the degeneration of nigrostriatal dopaminergic neurons. However, postmortem evidence indicates that pathology lower brainstem regions, such as pons and medulla, precedes nigral involvement. Consistently, pontomedullary damage was implicated structural PET imaging in early PD. Neurochemical correlates this pathological involvement PD are unknown. Methodology/Principal Finding To map biochemical alterations brains individuals with...
Abstract Parkinson's disease (PD) is associated with oxidative stress and decreased nigral glutathione (GSH), suggesting that therapies boost GSH may have a disease‐modifying effect. Intravenous administration of high dose N‐acetylcysteine (NAC), well‐known antioxidant precursor, increases blood brain in individuals PD Gaucher healthy controls. To characterize the pharmacokinetics repeated oral doses NAC their effect on measures, we conducted 4‐week open‐label prospective study (n = 5)...
ABSTRACT Objective: Examine relationships among neurodegenerative biomarkers and PD motor nonmotor symptoms. Background: CSF alpha‐synuclein is decreased in versus healthy controls, but whether plasma saliva differentiate these groups controversial. Correlations of biofluids (CSF, plasma, saliva) or (eg, beta‐amyloid, tau [total, phosphorylated]) are not fully understood. The with clinical features remain unclear. Methods: BioFIND, a cross‐sectional, observational study, examines biomarker...
<h3>Objective:</h3> To examine the utility and reliability of volumetric MRI in measuring disease progression 4 repeat tauopathies, progressive supranuclear palsy (PSP) corticobasal syndrome (CBS), to support clinical development new tau-directed therapeutic agents. <h3>Methods:</h3> Six- 12-month changes regional volumes PSP Rating Scale scores were examined 55 patients with 33 CBS (78% amyloid PET negative) compared 30 normal controls from a multicenter natural history study. Longitudinal...
Abstract Postmortem demonstration of increased iron in the substantia nigra (SN) is a well‐appreciated finding Parkinson's disease (PD). Iron facilitates generation free radicals, which are thought to play role dopamine neuronal loss. To date, however, magnetic resonance imaging (MRI) has failed show significant vivo differences SN levels subjects with PD versus control subjects. This may be due limitations tissue contrasts achievable conventional T 1 ‐ and 2 ‐weighted MRI sequences that...
To determine the ability of CSF biomarkers to predict disease progression in progressive supranuclear palsy (PSP).We compared baseline β-amyloid1-42, tau, phosphorylated tau 181 (p-tau), and neurofilament light chain (NfL) concentrations, measured by INNO-BIA AlzBio3 or ELISA, 52-week changes clinical (PSP Rating Scale [PSPRS] Schwab England Activities Daily Living [SEADL]), neuropsychological, regional brain volumes on MRI using linear mixed effects models controlled for age, sex, severity,...
To examine the feasibility, acceptability, and preliminary effects of Hatha yoga on oxidative stress, motor function, non-motor symptoms among individuals with Parkinson’s disease (PD). The study has a pilot randomized controlled trial design two arms: an immediate treatment group wait-list control group. yoga-for-PD program was implemented via twice weekly 60-min group-based classes for 12 weeks. Participants were assessed at baseline, weeks, 6 months post-intervention. Outcome measures...
Abstract Researchers are rapidly developing and deploying highly portable MRI technology to conduct field-based research. The new will widen access include investigators in remote unconventional settings facilitate greater inclusion of rural, economically disadvantaged, historically underrepresented populations. To address the ethical, legal, societal issues raised by accessible MRI, an interdisciplinary Working Group (WG) engaged a multi-year structured process analysis consensus building,...
Abstract The ε4 allele of the apolipoprotein E gene (APOE4) has been consistently associated with a greater risk Alzheimer's disease (AD) as well an earlier onset AD. It is possible that APOE4 may also play role in etiology other neurodegenerative disorders, such Parkinson's (PD). APOE genotype, age onset, duration, smoking history, and dementia status were collected for families PD, yielding 324 Caucasian complete information. Logistic regression employing one individual per family...