A5015619510- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Transcranial Magnetic Stimulation Studies
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Muscle activation and electromyography studies
- Neurotransmitter Receptor Influence on Behavior
- Visual perception and processing mechanisms
- Neuroethics, Human Enhancement, Biomedical Innovations
- Memory and Neural Mechanisms
- Ginseng Biological Effects and Applications
- Pharmacological Effects and Toxicity Studies
- Advanced Proteomics Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Ship Hydrodynamics and Maneuverability
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Marine and Offshore Engineering Studies
- Cancer, Stress, Anesthesia, and Immune Response
National Institute of Mental Health
2019
National Institutes of Health
2018
Saint Louis University
2004-2010
Baoshan College
2010
United States Department of Health and Human Services
2008
University of Illinois Urbana-Champaign
2002-2006
Indiana University Bloomington
1997-2003
Society for Neuroscience
2002
Winona State University
2002
Indiana University
2001
The BRAIN Initiative arose from a grand challenge to "accelerate the development and application of new technologies that will enable researchers produce dynamic pictures brain show how individual cells complex neural circuits interact at speed thought." is public-private effort focused on use powerful tools for acquiring fundamental insights about information processing occurs in central nervous system (CNS). As enters its fifth year, NIH has supported >500 principal investigators, who have...
The peptide content of individual mammalian cells is profiled using matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry. Both enzymatic and nonenzymatic procedures, including a glycerol cell stabilization method, are reported for the isolation in manner compatible with MALDI MS measurements. Guided microdeposition matrix allows samples to be created suitable analyte-to-matrix ratios. More than 15 peptides observed rat intermediate pituitary cells. combination...
Enhanced proliferation of airway smooth muscle is thought to contribute the pathogenesis asthma and other obstructive diseases. Lysophosphatidic acid (LPA) a simple bioactive lipid mediator that stimulates mitogenesis in fibroblasts some cell types. The effects LPA on cultured human cells were determined by measuring [3H]thymidine incorporation into cellular DNA. induced concentration-dependent stimulation similar magnitude serum, with 50 microM being those 5% serum. Stimulation serum was...
### Background on the National Institutes of Health BRAIN Initiative and neuroethics The (NIH) works tirelessly to support best science ensure that its funded research adheres highest ethical standards. From inception, NIH Brain Research through
We have previously shown that most of the reorganization typically follows median nerve transection in adult squirrel monkeys is dependent on normally functioning N-methyl-D-aspartate (NMDA) receptors. Here, we evaluated two additional hypotheses: (1) immediate "unmasking" found after NMDA receptor-dependent? and (2) are receptors necessary for both initiation maintenance second phase reorganizational changes, or only former? To address these issues, implanted osmotic minipumps...
Abstract Background Topographic reorganization of central maps following peripheral nerve injury has been well characterized. Despite extensive documentation these physiological changes, the underlying anatomical correlates have yet to be fully explored. In this study, we used Golgi impregnation and light microscopy assess dendritic morphology denervation glabrous hand surface in adult primates. Results After survival durations that permit complete physiologically-defined reorganization,...
Abstract The neurological deficits exhibited by patients with Fragile X syndrome (FraX) have been attributed to the absence of Mental Retardation Protein (FMRP), product FMR1 gene, which is nonfunctional in these individuals. While a great deal has learned about FraX using non‐invasive techniques and autopsy tissue from humans, limited availability subjects specimens severely restricts rate at such data can be collected types experimental questions posed. In view limitations, transgenic...
Summary: Purpose: Cognitive deficits associated with chronic treatment phenytoin (PHT) have been reported. PHT blocks transfer from a signaled appetitive bar press to an active avoidance response in rats. We investigated the effects of and prodrug fosphenytoin rabbits required learn discrimination reversal classical eyeblink conditioning paradigm. Methods: Before drug was started, were trained produce discriminated response. (n = 7) administered centrally or 2) given systemically. Control...
Opioid receptor signaling via the ERK/MAP kinase phosphorylation cascade initiates diverse cellular responses that are cell type dependent. In astrocytes, multiple μ opioid mediated mechanisms of ERK activation exist temporally distinctive and feature different outcomes. Upon discovering chronic opiate treatment rats followed by spontaneous withdrawal down regulates thrombospondin1 (TSP1) expression in nucleus accumbens cortex, we investigated mechanism action this modulation astrocytes....