A5091277767- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health and Psychiatry
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Medical Imaging Techniques and Applications
- Bipolar Disorder and Treatment
- Fetal and Pediatric Neurological Disorders
- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Personality Disorders and Psychopathology
- Neuroscience and Neuropharmacology Research
- Child and Adolescent Psychosocial and Emotional Development
- Medical Image Segmentation Techniques
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Mental Health Treatment and Access
- Neurology and Historical Studies
Karolinska Institutet
2006-2024
University of Iowa
2014-2023
Karolinska University Hospital
2005-2016
University of Gothenburg
2012
Lund University
2012
Charité - Universitätsmedizin Berlin
2010
University of Iowa Health Care
2004-2010
Washington University in St. Louis
1980-2010
Yale University
1997-2010
Advisory Board Company (United States)
2009-2010
Recently, a renaissance of interest in "negative symptoms," eg, affective flattening or impoverishment speech and language, has occurred. Although some investigators believe that these symptoms are important indicators outcome, response to treatment, perhaps distinct, underlying pathologic process, research on the negative-symptom syndrome schizophrenia been handicapped because no standard instrument existed assess it. This investigation reports developed Scale for Assessment Negative...
• We developed criteria for dividing the schizophrenic syndrome into three subtypes: positive, negative, and mixed schizophrenia. Positive schizophrenia is characterized by prominent delusions, hallucinations, positive formal thought disorder, persistently bizarre behavior; negative schizophrenia, affective flattening, alogia, avolition, anhedonia, attentional impairment. In either<i>both</i>negative symptoms are prominent, or<i>neither</i>is prominent. explored validity of these in a...
• Data concerning familial history of psychiatric disorders are often used to assist in diagnosis, examine the role genetic or nongenetic factors etiology, develop new methods classification. Information prevalence may be collected by two different methods: family method (obtaining information from patient a relative all members), and study (interviewing directly as many relatives possible their own present past symptomatology). This compares these methods. In general, is preferred since...
The Scale for the Assessment of Negative Symptoms (SANS) was first instrument developed in order to provide comprehensive assessment negative symptoms schizophrenia (Andreasen, 1982, 1983). It consists five scales that evaluate different aspects symptoms: alogia, affective blunting, avolition-apathy, anhedonia-asociality, and attentional impairment. Each these can be rated globally, but addition detailed observations are made achieve global rating. is complemented by a Positive (SAPS), which...
• The Comprehensive Assessment of Symptoms and History was developed for research studies schizophrenia spectrum conditions affective conditions. It is designed to provide a comprehensive information base concerning current past signs symptoms, premorbid functioning, cognitive sociodemographic status, treatment, course illness. Because the broad, it not wedded specific diagnostic system but rather permits clinicians investigators make diagnoses using wide range systems, including Research...
Context: Progressive brain volume changes in schizophrenia are thought to be due principally the disease.However, recent animal studies indicate that antipsychotics, mainstay of treatment for patients, may also contribute tissue decrement.Because antipsychotics prescribed long periods patients and have increasingly widespread use other psychiatric disorders, it is imperative determine their long-term effects on human brain.Objective: To evaluate relative contributions 4 potential predictors...
OBJECTIVE: The relationship between cognition and outcome in people with schizophrenia has been established studies that, for the most part, examined chronic patients were cross-sectional design. purpose of this study was to analyze relationships neurocognitive variables assessed at illness onset functional a longitudinal An additional area interest whether severity negative symptoms would predict independently from or there be an overlap their predictive power. METHOD: authors administered...
• The "hypofrontality hypothesis" has been supported by many neuroimaging studies, but not all, perhaps because of heterogeneity samples. present study examined three different samples that permitted assessment a variety confounders, such as effects long-term treatment, chronicity illness, and presenting phenomenology: (1) 13 neuroleptic-naive schizophrenic patients, (2) 23 nonnaive patients who had relatively chronically ill were medication free for at least 3 weeks, (3) 15 healthy normal...
Rates of mental illness were examined in 30 creative writers, matched control subjects, and the first-degree relatives both groups. The writers had a substantially higher rate illness, predominantly affective disorder, with tendency toward bipolar subtype. There was also prevalence disorder creativity writers' relatives, suggesting that these traits run together families could be genetically mediated. Both subjects IQs superior range; excelled only on WAIS vocabulary subtest, confirming...
<h3>Background:</h3> The "group of schizophrenias," normally referred to with a single nominative, is phenomenologically heterogeneous. Its symptoms represent multiple psychological domains, including perception, inferential thinking, language, attention, social interaction, emotion expression, and volition. Studies psychopathology have simplified this complex array in several ways, one which subdivision into positive negative symptoms. <h3>Methods:</h3> This study examined the vs...
• Bleulerian psychiatry has considered thought disorder to be a pathognomonic symptom of schizophrenia. Evaluation the perspective been severely handicapped by lack any standard and widely agreed-on definition disorder. Consequently, conceptualization tended quite diverse, evaluation unreliable. This report presents set definitions linguistic cognitive behaviors frequently observed in patients. These derive from clinical experience, use an empirical approach, avoid making inferences about...
Schizophrenia is a complex illness characterized by multiple types of symptoms involving many aspects cognition and emotion. Most efforts to identify its underlying neural substrates have focused on strategy that relates single symptom brain region. An alternative hypothesis, the variety could be explained lesion in midline circuits mediating attention information processing, explored. Magnetic resonance images from patients controls were transformed with "bounding box" produce an "average...
Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps occur variety of mental activities. Working interactively with prefrontal cortex, cerebellum play role both motor and performance. This positron-emission tomography study suggests presence prefrontal-thalamic-cerebellar network is activated when normal subjects recall complex narrative material, but dysfunctional schizophrenic patients they perform same...
This study used positron emission tomography to examine two kinds of personal memory that are in psychiatric evaluation: focused episodic (recall past experience, employed "taking a history") and random (uncensored thinking about examined during analytic therapy using free association). For comparison, third task was tap impersonal represents general information the world ("semantic memory").Thirteen subjects were studied [15O]H2O method obtain quantitative measurements cerebral blood flow....