A5069859534- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Reading and Literacy Development
- Neonatal and fetal brain pathology
- Stroke Rehabilitation and Recovery
- Language Development and Disorders
- Hemispheric Asymmetry in Neuroscience
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Music Perception
- Neural and Behavioral Psychology Studies
- Hearing Loss and Rehabilitation
- Infant Development and Preterm Care
- Acute Ischemic Stroke Management
- Transcranial Magnetic Stimulation Studies
- Innovative Teaching and Learning Methods
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Action Observation and Synchronization
- Spatial Neglect and Hemispheric Dysfunction
- Hearing, Cochlea, Tinnitus, Genetics
- Neurological disorders and treatments
- Balance, Gait, and Falls Prevention
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2014-2025
University of Cincinnati Medical Center
2015-2023
Google (United States)
2021-2023
Alexander Graham Bell Association for the Deaf and Hard of Hearing
2023
Perinatal Institute
2023
University of Rochester
2005-2022
University of Alabama at Birmingham
2019-2022
Medical College of Wisconsin
2022
Cleveland Clinic
2022
Changes in the distribution of language function brain have been documented from infancy through adulthood. Even macroscopic measures lateralization reflect a dynamic process development. In this review, we summarize series functional MRI studies skills children ages five to 18 years, both typically-developing and with injuries or neurological disorders that occur at different developmental stages degrees severity. These used battery fMRI-compatible tasks designed tap sentential lexical...
Background:Aphasia affects 1/3 of stroke patients with improvements noted only in some them. The goal this exploratory study was to provide preliminary evidence regarding safety and efficacy fMRI-guided excitatory repetitive transcranial magnetic stimulation (rTMS) applied the residual left-hemispheric Broca's area for chronic aphasia treatment.Material/Methods:We enrolled 8 moderate or severe >1 year after LMCA stroke. Linguistic battery administered pre-/post-rTMS; a semantic decision/tone...
Purpose: Several adult studies have documented the importance of peri-stroke areas to aphasia recovery. But, examining differences in patterns cortical participation language comprehension patients who (LMCA-R) or not recovered (LMCA-NR) from left middle cerebral artery infarction been performed up date. Methods: In this study, we compare correlates using fMRI and semantic decision/tone decision task 9 LMCA-R 18 LMCA-NR matched at time stroke for age handedness. We examine performance by...
To evaluate changes in tremor severity and motor/emotion-processing circuits response to cognitive behavioral therapy (CBT) delivered as treatment for functional (FT), the most common movement disorder adults.Fifteen patients with FT underwent fMRI motor, basic-emotion, intense-emotion tasks before after 12 weeks of CBT. Baseline was compared those 25 healthy controls (HCs). The main clinical endpoint score (sum severity, duration, incapacitation subscores) adapted from Rating Scale...
Abstract Poor phonological processing has typically been considered the main cause of dyslexia. However, visuo‐attentional abnormalities have described as well. The goal present study was to determine involvement visual attention during fluent reading in children with dyslexia and typical readers. Here, 75 (8–12 years old; 36 readers, 39 dyslexia) completed cognitive assessments. Neuroimaging data were acquired while performed a task (a) condition where text remained on screen (Still) versus...
Purpose: The lack of appropriate assessments affects populations presumed to be most at risk for speech and language concerns, one them being children with a history preterm birth. This study aims examine whether cultural bias is present in two currently available tests Black under 3 years age: the Communication Symbolic Behavior Scales (CSBS) MacArthur-Bates Communicative Development Inventories (CDI). Method: uses data from Early NICU Graduates' Study, National Institutes Health–funded,...
Abstract Purpose To use functional MRI (fMRI) methods to visualize a network of auditory and language‐processing brain regions associated with processing an aurally‐presented story. We compare passive listening (PL) story paradigm active‐response (AR) version including online performance monitoring sparse acquisition technique. Materials Methods Twenty children (ages 11–13 years) completed PL AR tasks. The presented alternating 30‐second blocks stories tones; the segments, comprehension...
Despite its high prevalence and associated disability, the neural correlates of emotion processing in patients with functional (psychogenic) tremor (FT), most common movement disorder, remain poorly understood. In this cross sectional magnetic resonance imaging (fMRI) study at 4T, 27 subjects FT, 16 essential (ET), 25 healthy controls (HCs) underwent a finger-tapping motor task, basic-emotion an intense-emotion task to probe circuitries. Anatomical MRI data were processed FSL (FMRIB Software...
Abstract Objective To define left temporal lobe regions where surgical resection produces a persistent postoperative decline in naming visual objects. Methods Pre‐ and brain magnetic resonance imaging data picture (Boston Naming Test) scores were obtained prospectively from 59 people with drug‐resistant epilepsy. All patients had hemisphere language dominance at baseline underwent or ablation the lobe. Postoperative assessment occurred approximately 7 months after surgery. Surgical lesions...
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, emotional development beginning prenatally planned through early childhood. acquisition of multimodal magnetic resonance-based brain data is central to the study's core protocol. However, application Magnetic Resonance Imaging (MRI) methods in this population complicated by technical challenges difficulties imaging life. Overcoming...
Objective The aim of this study was to determine the frequency‐dependent, spatiotemporal involvement corticothalamic networks generation absence seizures. Methods Magnetoencephalography recordings were obtained in 12 subjects (44 seizures) with untreated childhood Time‐frequency analysis each seizure performed bandwidths significant power at ictal onset. Source localization then completed brain regions contributing generalized spike and wave discharges seen on electroencephalogram. Results...
Effective techniques that allow children to complete magnetic resonance imaging (MRI) scans without sedation are high priority for the community. We used behavioral approaches scan 64 sleeping infants and toddlers younger than 4 years, 156 awake aged 2.5 18 a neuroimaging research protocol. Infants their families participated in desensitization protocol several days, then scanning was performed at child's bedtime during natural sleep. For young children, included tangible reinforcers,...
ABSTRACT Objective We sought to determine whether abnormalities in emotion processing underlie functional (psychogenic) dystonia, one of the most common movement disorders. Methods Motor and circuits were examined 12 participants with primary organic 25 healthy controls using magnetic resonance imaging at 4T a finger‐tapping task (motor task), basic emotion‐recognition (emotional faces an intense‐emotion stimuli task. Results There no differences motor activation between groups. In task,...
Abstract Introduction Dyslexia is characterized by slow, inaccurate reading. Previous studies have shown that the Reading Acceleration Program (RAP) improves reading speed and accuracy in children adults with dyslexia typical readers across different orthographies. However, effect of RAP on neural circuitry has not been established. In current study, we examined training regions interest for using a lexical decision task during fMRI difficulties readers. Methods Children (8–12 years old)...
Abstract Current theories of language recovery after stroke are limited by a reliance on small studies. Here, we aimed to test predictions current theory and resolve inconsistencies regarding right hemispheric contributions long‐term recovery. We first defined the canonical semantic network in 43 healthy controls. Then, group patients with chronic post‐stroke aphasia, tested whether activity this predicted performance measures comprehension, naming, fluency while controlling for lesion...
Purpose: Repetitive transcranial magnetic stimulation (rTMS) is a potentially effective, noninvasive tool for language mapping. However, there paucity of data in pediatric patients. In this study, we aimed to map sites healthy participants with navigated rTMS. Methods: Children aged 5 18 years underwent bilateral Stimulation was delivered at Hz during visual-naming and auditory verb-generation tasks 1 2 second bursts. We targeted 33 standardized per hemisphere. total, 34 completed the task,...