A5028966468- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Lanthanide and Transition Metal Complexes
- NMR spectroscopy and applications
- Neuroscience and Neuropharmacology Research
- MRI in cancer diagnosis
- Visual perception and processing mechanisms
- Transcranial Magnetic Stimulation Studies
- Electron Spin Resonance Studies
- Cardiac Valve Diseases and Treatments
- Muscle activation and electromyography studies
- Metabolomics and Mass Spectrometry Studies
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Vestibular and auditory disorders
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Motor Control and Adaptation
Wellcome Centre for Integrative Neuroimaging
2016-2025
University of Oxford
2016-2025
University of Amsterdam
2024
Amsterdam University Medical Centers
2024
John Radcliffe Hospital
2013-2024
University of Toronto
2024
Hospital for Sick Children
2024
Cardiff University
2024
Boston Children's Hospital
2021-2024
Harvard University
2024
Concentric left ventricular (LV) remodeling is associated with adverse cardiovascular events and frequently observed in patients type 2 diabetes mellitus (T2DM). Despite this, the cause of concentric per se unclear, but it may be related to cardiac steatosis impaired myocardial energetics. Thus, we investigated relationship between metabolic changes LV T2DM. Forty-six nonhypertensive T2DM 20 matched control subjects underwent magnetic resonance assess (LV mass–to–LV end diastolic volume...
Type 2 diabetes (T2D) and obesity are associated with nonalcoholic fatty liver disease, cardiomyopathy, cardiovascular mortality. Both show stronger links between ectopic visceral fat deposition, an increased cardiometabolic risk compared subcutaneous fat.
The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation efficiency of adenosine triphosphate production, with mixed results.
Dynamic (2D) MRS is a collection of techniques where acquisitions spectra are repeated under varying experimental or physiological conditions. comprises rich set contrasts, including diffusion-weighted, relaxation-weighted, functional, edited, hyperpolarized spectroscopy, leading to quantitative insights into multiple microstructural processes. Conventional approaches dynamic analysis ignore the shared information between spectra, and instead proceed by independently fitting noisy individual...
Patients with type 2 diabetes mellitus (T2DM) are known to have impaired resting myocardial energetics and perfusion reserve, even in the absence of obstructive epicardial coronary artery disease (CAD). Whether or not pre-existing energetic deficit is exacerbated by exercise, whether causes deoxygenation further derangement during exercise stress, uncertain.
In vivo magnetic resonance spectroscopy provides insight into metabolism in the human body. New acquisition protocols are often proposed to improve quality or efficiency of data collection. Processing pipelines must also be developed use these optimally. Current fitting software is either targeted at general fitting, for specific protocols. We therefore introduce MATLAB-based OXford Spectroscopy Analysis (OXSA) toolbox allow researchers rapidly develop their own customised processing...
Purpose Phosphorus magnetic resonance spectroscopy ( 31 P‐MRS) affords unique insight into cardiac energetics but has a low intrinsic signal‐to‐noise ratio (SNR) in humans. Theory predicts an increased P‐MRS SNR at 7T, offering exciting possibilities to better investigate metabolism. We therefore compare the performance of human 7T 3T, and measure T 1 s for P metabolites 7T. Methods Matched data were acquired 3T on nine normal volunteers. A novel Look‐Locker CSI acquisition fitting approach...
Purpose We introduce FSL‐MRS, an end‐to‐end, modular, open‐source MRS analysis toolbox. It provides spectroscopic data conversion, preprocessing, spectral simulation, fitting, quantitation, and visualization. Methods The FSL‐MRS package is modular. Its programs operate on in a standard format (Neuroimaging Informatics Technology Initiative [NIfTI]) capable of storing single‐voxel multivoxel spectroscopy, including spatial orientation information. toolbox includes tools for preprocessing raw...
Abstract Post-mortem studies have shown that patients dying from severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection frequently pathological changes in their CNS, particularly the brainstem. Many of these are proposed to result para-infectious and/or post-infection immune responses. Clinical symptoms such as fatigue, breathlessness, and chest pain reported post-hospitalized disease 2019 (COVID-19) patients. We propose part due damage key neuromodulatory brainstem nuclei....
Abstract Phosphorus-31 magnetic resonance spectroscopic imaging ( 31 P-MRSI) provides valuable non-invasivein vivoinformation on tissue metabolism but is burdened by poor sensitivity and prolonged scan duration. Ultra-short echo time (UTE) acquisitions minimize signal loss when probing signals with relatively short spin-spin relaxation (T 2 ), while also preventing first-order dephasing. Here, a three-dimensional (3D) UTE sequence rosette k-space trajectory (PETALUTE) applied to P-MRSI at...
Lone atrial fibrillation (AF) may reflect a subclinical cardiomyopathy that persists after sinus rhythm (SR) restoration, providing substrate for AF recurrence. To test this hypothesis, we investigated the effect of restoring SR by catheter ablation on left ventricular (LV) function and energetics in patients with but no significant comorbidities.Fifty-three symptomatic paroxysmal or persistent without valvular disease, uncontrolled hypertension, coronary artery thyroid systemic inflammatory...
Obesity is strongly associated with exercise intolerance and the development of heart failure. Whereas myocardial energetics diastolic function are impaired in obesity, systolic usually preserved. This suggests that rate ATP delivery maintained, but this has never been explored human obesity. We hypothesized transfer through creatine kinase (CK) (kfCKrest) would be increased, compensating for depleted energy stores (phosphocreatine/ATP), potentially limiting greater during increased...
Heating of gradient coils and passive shim components is a common cause instability in the B0 field, especially when intensive sequences are used. The aim study was to set benchmark for typical drift encountered during MR spectroscopy (MRS) assess need real-time field-frequency locking on MRI scanners by comparing field data from large number sites. A standardized protocol developed 80 participating sites using 99 3T 3 major vendors. Phantom water signals were acquired before after an EPI...
Multiple data formats in the MRS community currently hinder sharing and integration. NIfTI-MRS is proposed as a standard spectroscopy format, implemented an extension to Neuroimaging informatics technology initiative (NIfTI) format. This standardized format can facilitate algorithm development well ease integration of analysis alongside other imaging modalities.
Edited MRS sequences are widely used for studying γ‐aminobutyric acid (GABA) in the human brain. Several algorithms available modelling these data, deriving metabolite concentration estimates through peak fitting or a linear combination of basis spectra. The present study compares seven such algorithms, using data obtained large multisite study. GABA‐edited (GABA+, TE = 68 ms MEGA‐PRESS) from 222 subjects at 20 sites were processed via standardised pipeline, before with FSL‐MRS, Gannet,...
Abstract Brain cell structure and function reflect neurodevelopment, plasticity, aging; changes can help flag pathological processes such as neurodegeneration neuroinflammation. Accurate quantitative methods to noninvasively disentangle cellular structural features are needed a substantial focus of brain research. Diffusion‐weighted MRS (dMRS) gives access diffusion properties endogenous intracellular metabolites that preferentially located inside specific populations. Despite its great...
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, emotional development beginning prenatally planned through early childhood. acquisition of multimodal magnetic resonance-based brain data is central to the study's core protocol. However, application Magnetic Resonance Imaging (MRI) methods in this population complicated by technical challenges difficulties imaging life. Overcoming...
Abstract Deuterium metabolic imaging (DMI) is an emerging magnetic resonance technique, for non‐invasive mapping of human brain glucose metabolism following oral or intravenous administration deuterium‐labeled glucose. Regional differences in can be observed various pathologies, such as Alzheimer's disease, cancer, epilepsy schizophrenia, but the achievable spatial resolution conventional phase‐encoded DMI methods limited due to prolonged acquisition times rendering submilliliter isotropic...
Increasing numbers of 7 T (7 T) magnetic resonance imaging (MRI) scanners are in research and clinical use. MRI can increase the scanning speed, spatial resolution contrast-to-noise-ratio many neuroimaging protocols, but technical challenges implementation have been addressed a variety ways across sites. In order to facilitate multi-centre studies ensure consistency findings sites, it is desirable that sites implement common high-quality protocols accommodate different scanner models...
Gene therapy using hematopoietic stem and progenitor cells is altering the therapeutic landscape for patients with hematologic, immunologic, metabolic disorders but has not yet been successfully developed individuals bone marrow failure syndrome Diamond-Blackfan anemia (DBA). More than 30 mutations cause DBA through impaired ribosome function lead to inefficient translation of erythroid master regulator GATA1, providing a potential avenue intervention applicable all DBA, irrespective...
Objectives: We sought to determine whether receipt of the American Diabetes Association's recommended clinical services was similar among insured subjects with and without mental disorders during period 1996 2001. Research Design: Our study a retrospective analysis Blue Cross/Blue Shield Iowa administrative claims data, 1996–2001. Subjects: studied 26,020 adults diabetes; 6,627 (25%) had coexisting disorder. Measures: Service included hemoglobin A1c (HbA1c) testing, dilated eye examination,...
Purpose To test whether the increased signal-to-noise ratio of phosphorus 31 (31P) magnetic resonance (MR) spectroscopy at 7 T improves precision in cardiac metabolite quantification patients with dilated cardiomyopathy (DCM) compared that 3 T. Materials and Methods Ethical approval was obtained, participants provided written informe consent. In a prospective study, 31P MR performed 25 DCM. Ten healthy matched control subjects underwent Paired Student t tests were to compare results between...
Cardiac phosphorus magnetic resonance spectroscopy (31P-MRS) provides unique insight into the mechanisms of heart failure. Yet, clinical applications have been hindered by restricted sensitivity surface radiofrequency-coils normally used. These permit analysis spectra only from interventricular septum, or large volumes myocardium, which may not be meaningful in focal disease. Löring et al. recently presented a prototype whole-body (52 cm diameter) transmit/receive birdcage coil for 31P at...