A5055514325- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Lanthanide and Transition Metal Complexes
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Functional Brain Connectivity Studies
- Hemoglobinopathies and Related Disorders
- Electron Spin Resonance Studies
- Advanced NMR Techniques and Applications
- Alzheimer's disease research and treatments
- Optical Coherence Tomography Applications
- Retinal Imaging and Analysis
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Atomic and Subatomic Physics Research
- Glaucoma and retinal disorders
- Photoacoustic and Ultrasonic Imaging
- Vestibular and auditory disorders
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Ophthalmology and Eye Disorders
- Cardiovascular Health and Disease Prevention
Philips (United States)
2011-2024
Philips (Finland)
2009-2024
Weifang Medical University
2022
Air Force Medical University
2014-2020
Xijing Hospital
2014-2016
Indiana University Bloomington
2007
Yale University
2004
Vanderbilt University
2004
Abstract Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core ADNI has been to improve methods for clinical trials disease (AD) and related disorders. Methods We review contributions MRI from present past cycles (ADNI‐1, ‐Grand Opportunity ‐2). also plans future‐ADNI‐3. Results Contributions include creating standardized acquisition protocols quality control methods; examining effect...
Purpose To quantify amide protein transfer (APT) effects in acidic ischemic lesions and assess the spatial‐temporal relationship among diffusion, perfusion, pH deficits acute stroke patients. Methods Thirty patients were scanned at 3 T. Quantitative APT (APT # ) measured using an extrapolated semisolid magnetization reference signal technique compared with commonly used MTR asym (3.5ppm) or APT‐weighted parameters. Results The images showed clear lesion, whereas signals slightly hypointense....
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, emotional development beginning prenatally planned through early childhood. acquisition of multimodal magnetic resonance-based brain data is central to the study's core protocol. However, application Magnetic Resonance Imaging (MRI) methods in this population complicated by technical challenges difficulties imaging life. Overcoming...
Traumatic brain injury (TBI) produces excessive glutamate, leading to excitotoxicity via the activation of glutamate receptors. Postsynaptic density scaffold proteins have crucial roles in mediating signal transduction from receptors their downstream mediators. Therefore, studies on mechanisms underlying regulation by can uncover new treatments for TBI. Here, we demonstrated that postsynaptic protein Homer 1a was neuroprotective against TBI vitro and vivo, this neuroprotection associated...
In this report, the feasibility of using blood as an agent for Chemical Exchange Saturation Transfer (CEST) effect is investigated.The CEST porcine samples was investigated on a 3.0 T MRI scanner various power levels and 14.1 NMR spectrometer. As proof-of-concept that can be used to image in vivo, technique applied two locations healthy human volunteers, namely, femoral artery M1-segment middle cerebral artery.The sample experiments showed maximum Magnetization Ratio asymmetry (MTRasym)...
Purpose To develop prospectively accelerated 3D CEST imaging using compressed sensing (CS), combined with a saturation scheme based on time‐interleaved parallel transmission. Methods A variable density pseudo‐random sampling pattern centric elliptical k‐space ordering was used for CS acceleration in 3D. Retrospective studies were performed phantoms to test the reconstruction scheme. Prospectively CS‐accelerated 3D‐CEST images acquired 10 healthy volunteers and 6 brain tumor patients an...
Purpose To develop velocity‐selective (VS) MR angiography (MRA) protocols for arteriography and venography with whole‐brain coverage. Methods Tissue suppression using saturation (VSS) pulse trains is sensitive to radiofrequency field (B 1 +) inhomogeneity. reduce its sensitivity, we replaced the low‐flip‐angle hard pulses in VSS train optimal composite (OCP) pulses. Additionally, new sequences were developed by placing spatially selective inversion a delay null signals from either venous or...
Purpose Velocity‐selective saturation (VSS) pulse trains provide a viable alternative to the spatially selective methods for measuring cerebral blood volume (CBV) by reducing sensitivity arterial transit time. This study is compare Fourier‐transform–based velocity‐selective (FT‐VSS) with conventional flow‐dephasing VSS techniques CBV quantification. Methods The proposed FT‐VSS label and control modules were compared utilizing double refocused hyperbolic tangent (DRHT) 8‐segment...
<h3>BACKGROUND AND PURPOSE:</h3> MR imaging is currently not used to evaluate CSF flow changes due short-lasting physiological maneuvers. The purpose of this study was the ability assess response a Valsalva maneuver in healthy participants. <h3>MATERIALS METHODS:</h3> A cardiac-gated fast cine-PC sequence with ≤15-second acquisition time 8 participants at foramen magnum rest, during, and immediately after controlled maneuver. mean displacement volume <i>V̄<sub>CSF</sub></i> during cardiac...
<h3>BACKGROUND AND PURPOSE:</h3> Invasive pressure studies have suggested that CSF flow across the foramen magnum may transiently decrease after coughing in patients with symptomatic Chiari I malformation. The purpose of this exploratory study was to demonstrate phenomenon noninvasively by assessing response malformation using MR pencil beam imaging and compare healthy participants. <h3>MATERIALS METHODS:</h3> Eight 6 participants were studied a temporal resolution ∼50 ms. Patients scanned...
<h3>BACKGROUND AND PURPOSE:</h3> Spiral MR imaging has several advantages compared with Cartesian that can be leveraged for added clinical value. A multicenter multireader study was designed to compare spiral standard-of-care postcontrast structural brain on the basis of relative performance in 10 metrics image quality, artifact prevalence, and diagnostic benefit. <h3>MATERIALS METHODS:</h3> Seven sites acquired 88 total subjects. For each subject, 2 scans: a 2D T1 spin-echo, 1 4 routine...
Abstract A new method is described that can correct the distortions due to multiple off‐resonance effects in echo planar imaging, including those caused by B 0 field inhomogeneities, eddy currents, and gradient waveform imperfections. The proposed uses a phase encoded acquisition as effective of Chen Wyricz (Chen Wyricz, Magn Reson Med 1999;41:1206–1213) correcting for distortions. Unlike Wyricz's approach, this works directly distorted space requires fewer scans. It also avoids difficulties...
<h3>BACKGROUND AND PURPOSE:</h3> Currently no quantitative objective test exists to determine disease severity in a patient with Chiari I malformation. Our aim was correlate symptomatic patients malformation cough-associated changes CSF flow as measured real-time MR imaging. <h3>MATERIALS METHODS:</h3> Thirteen (tonsillar herniation of ≥5 mm) were prospectively studied. A real-time, flow-sensitized pencil-beam imaging scan used measure stroke volume during rest and immediately following...
Recent neurophysiological and functional neuroimaging studies suggest that the memory decline found with normal aging is not solely due to regional disruptions in hippocampus, but also brought about by alterations coupling between hippocampus long-distance neocortical regions. However, anatomical basis for this "dyscoupling" has been fully revealed. In study, we applied a multimodal magnetic resonance imaging technique noninvasively examine large-scale hippocampal network of group middle...
Schematic of the construction MB-dsDNA competitive aptasensor based on (A) molecular docking simulation design and (B) its assembly (C) working principle exonuclease-assisted target recycling amplification strategy for AFB 1 detection.
This study used myelin water fraction (MWF) and geometric mean T2 time of the intra- extra-cellular (IET2) derived from a multi-spin echo sequence with compressed sensing (METRICS)2, as well T1 mapping MP1RAGE to evaluate long-term changes in myelination white matter integrity youths neonatal brain injury. We observed significant differences values IET2 normal appearing matter, but not lesions population young adults injury compared controls.
Purpose: To augment the qMRI multi-parametricity of Triple TSE to additionally include primary diffusion tensor imaging (DTI) functionality and with seamless geometric compatibility nPD, T1, T2 maps Triple-TSE framework. Methods: were generated algorithms based on Bloch Bloch-Torrey equations. Results: histogram analyses for phantom volunteer reveal well behaved data T2, MD, FA. Conclusion: Creating a unified clinical MP-qMRI protocol PD, seems within reach.
Motivation: To enable execution of open-source vendor-agnostic pulse sequences on Philips MRI scanners. Goal(s): develop a Pulseq interpreter for scanner. Approach: An intelligent interpreter, denoted "p2p" (Pulseq to Philips), was implemented in MATLAB. It converts Pulseq-generated .seq files into format compatible with sequence objects. Results: The p2p tested that included arbitrary gradient waveforms including custom spiral and crusher spelling out the words &lsquo;Philips...
Objective:To explore the normal values of otolith function tests and agerelated changes in health volunteers.Method: One hundred seventyone volunteers were distributed to seven age groups, all subjects accepted tests, including fundus photography, static subjective visual vertical(SSVV), cervical vestibular evoked myogenic potential(cVEMP)and ocular potential(oVEMP), photographs was used measure discfovea angle(DFA). DFA, SSVV VEMPs analyzed compared among groups. Result: For DFA...