A5059560314- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Obstructive Sleep Apnea Research
- Advanced Neuroimaging Techniques and Applications
- Quantum, superfluid, helium dynamics
- Advanced MRI Techniques and Applications
- Cold Atom Physics and Bose-Einstein Condensates
- Fetal and Pediatric Neurological Disorders
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Neuroscience of respiration and sleep
- Optical Imaging and Spectroscopy Techniques
- Spinal Dysraphism and Malformations
- Advanced NMR Techniques and Applications
- Neurosurgical Procedures and Complications
- Tracheal and airway disorders
- Balance, Gait, and Falls Prevention
- Atomic and Molecular Physics
- Effects of Vibration on Health
- Neonatal and fetal brain pathology
- Spectroscopy and Laser Applications
- Cerebral Palsy and Movement Disorders
- Voice and Speech Disorders
- Nuclear Physics and Applications
Albert Einstein College of Medicine
2016-2025
Montefiore Medical Center
2013-2025
Resonance Research (United States)
2010-2025
The Bronx Defenders
2023
Yeshiva University
2013-2015
Stony Brook University
1997-2013
Primary Children's Hospital
2009
Brookhaven National Laboratory
2007-2008
Cold Spring Harbor Laboratory
2007-2008
State University of New York
1997-2008
The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, therapeutic purposes. We describe a metabolic biomarker the detection quantification NPCs human vivo. used proton nuclear magnetic resonance spectroscopy to identify characterize which are enriched demonstrated its use as reference monitoring neurogenesis. To detect low concentrations vivo, we developed signal processing method that enabled...
Using a new method of xenon laser-polarization that permits the generation liter quantities hyperpolarized 129Xe gas, first imaging results from human chest and spectroscopy head have been obtained. With polarization levels approximately 2%, cross-sectional images lung gas-spaces with voxel volume 0.9 cm3 (signal-to-noise ratio (SNR), 28) were acquired three dissolved-phase resonances in spectra detected. In head, one prominent resonance, presumably brain parenchyma, was anticipated...
We have observed the spectrum of long range molecular states singly excited ${\mathrm{Na}}_{2}$ formed by photoassociation during ultracold associative ionization collisions laser-cooled Na atoms. The low kinetic energy collision allows us to obtain very high resolution spectra and observe close dissociation limit. shows regular vibrational series characteristic 1/${\mathit{R}}^{3}$ portion ${1}_{\mathit{g}}$ potential (asymptotically ${\mathit{S}}_{1/2}$+${\mathit{P}}_{3/2}$) as well...
We have performed a test of Lorentz invariance by searching for time-dependent quadrupole splitting Zeeman levels in $^{21}\mathrm{Ne}$. A component the at twice Earth's sidereal frequency (${\mathrm{\ensuremath{\Omega}}}_{\mathrm{S}}$) would suggest preferred direction which affects local physics $^{21}\mathrm{Ne}$ nucleus. The technique employs polarized and $^{3}\mathrm{He}$ gases produced spin exchange with laser optically pumped Rb. Both species are contained same glass cell, providing...
Building on previous National Institutes of Health-sponsored symposia hydrocephalus research, "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes" was held in Seattle, Washington, July 9-11, 2012. Plenary sessions were organized into four major themes, each with two subtopics: Causes (Genetics and Pathophysiological Modifications); Diagnosis (Biomarkers Neuroimaging); Treatment (Bioengineering Advances Surgical Treatments); Outcome (Neuropsychological Neurological)....
Abstract Hyperpolarized 129 Xe has been used to obtain gas phase images of mouse lung in vivo , showing distinct ventilation variation as a function the breathing cycle. Spectra thorax show complex structure both (−4 3 ppm) and tissue‐dissolved (190‐205 regions. The alveolar peak shows correlated intensity frequency oscillations, attributable changes volume during breathing. two major dissolved peaks near 195‐200 ppm are attributed parenchyma blood; they reach maximum 5‐10 s decay with an...
The technique of spin exchange between laser optically pumped alkali-metal vapor and $^{3}\mathrm{He}$ can provide several atm ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}3}$ (\ensuremath{\approxeq}${10}^{21}$ atoms in a volume 6 ${\mathrm{cm}}^{3}$) nearly 100% polarized $^{3}\mathrm{He}$. We have recently produced 40% polarization ${10}^{20}$ (3 1.3 ${\mathrm{cm}}^{3}$). It should therefore be possible to produce useful targets by this technique. realization practical target is limited the...
Obstructive sleep apnea syndrome (OSAS) is associated with intermittent hypoxia and loss. In children, impairments of cognitive function are important manifestations, but the underlying pathology unknown. We hypothesized that OSAS would affect dentate gyrus, a hippocampal subdivision essential to neurogenesis cognition, this impact further in children. children ( n = 11) control subjects 12; age sex matched), we performed diffusion tensor imaging structural MRI, polysomnography,...
We have investigated high-density Rb optical pumping in polarized $^{3}\mathrm{He}$ targets and present measurements of collisional relaxation rates studies diffusion-driven wall the polarization. show that a boundary layer resides vicinity cell walls within which polarization gradient is established by diffusion. Absorption incident laser radiation this leads to striking decrease optical-pumping efficiency for resonant light but has little effect off-resonant light. Our theory introduces...
We use photoassociation of ultracold Na to study transitions from free atoms bound molecules. obtain rovibrational spectra the 1g, 0+u, and, for first time, 0−g ‘‘purely long-range’’ state Na2, all which dissociate Na(3 2S1/2)+Na(3 2P3/2).
Abstract Objectives: We tested whether dynamic interaction between limbic regions supports a control systems model of excitatory and inhibitory components negative feedback loop, dysregulation those dynamics might correlate with trait differences in anxiety their cardiac characteristics among healthy adults. Experimental Design: Sixty‐five subjects received fMRI scans while passively viewing angry, fearful, happy, neutral facial stimuli. Subjects also completed inventory, were monitored...
We have studied laser optical pumping of Rb at densities up to 4\ifmmode\times\else\texttimes\fi{}${10}^{14}$ atoms/${\mathrm{cm}}^{3}$ and produced polarized $^{3}\mathrm{He}$ by spin exchange with Rb. Numerical calculations show that for a high-density vapor GaAlAs diode arrays can provide results similar those obtained broadband ${\mathrm{Kr}}^{+}$-ion--dye-laser system. confirmed these measurements using 40-GHz full width half maximum bandwidth dye 100- 500-mW (Spectra Diode Labs Array...
To test whether memantine can prevent methotrexate-induced cognitive deficits in a preclinical model.After noting that methotrexate exposure induces prolonged elevations of the glutamate analog homocysteic acid (HCA) within cerebrospinal fluid, we tested intrathecal injection HCA would produce memory similar to those observed after methotrexate. We then memantine, an antagonist N-methyl-d-aspartate (NMDA) subclass receptors, could protect animals treated with clinically relevant doses...
We observe a new resonance structure in the associative ionization spectrum of laser-cooled sodium due to collision two atoms different ground hyperfine states. This is doubly resonant excitation at moderate internuclear separation through intermediate molecular Substructure within this evidence for role bound states process. present calculations modeling effect ground-state structure, importance which was unanticipated earlier theoretical studies.
We report measurements of asymmetries in quasielastic scattering polarized electrons from ${\mathrm{He}}^{3}$ at ${\mathrm{Q}}^{2}$=-0.2 GeV/c${)}^{2}$. measure ${\mathrm{A}}_{\mathrm{T}\ensuremath{'}}$=(-2.6\ifmmode\pm\else\textpm\fi{}0.9\ifmmode\pm\else\textpm\fi{}0.46)% and ${\mathrm{A}}_{\mathrm{TL}\ensuremath{'}}$=(+1.75\ifmmode\pm\else\textpm\fi{}1.2\ifmmode\pm\else\textpm\fi{}0.31)%. The asymmetry ${\mathrm{A}}_{\mathrm{T}\ensuremath{'}}$ depends predominantly on the previously...
Object The relationship between the waveform of intracranial pressure (ICP) and arterial blood can be quantitatively characterized using a newly developed technique in systems analysis, time-varying transfer function. This considers as an input signal composed multiple frequencies represented output ICP according to function imposed by system on signal. change with time physiological manipulations. authors examined data obtained from canine experiments involving manipulations ICP. Methods...
The role of cervical muscle (neck) strength in traumatic brain and spine injury chronic neck pain disorders is an area active research. Characterization the normal ranges healthy young adults essential to designing future investigations how may act as a modifier for risk progression head disorders.To develop normative reference database adult population, evaluate relationship anthropometric measurements.Cross-sectional.An academic medical center research institution.A total 157 (18-35 years...