A5046525385- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Children's Physical and Motor Development
- Eating Disorders and Behaviors
- EEG and Brain-Computer Interfaces
- HIV Research and Treatment
- Neural and Behavioral Psychology Studies
- Muscle activation and electromyography studies
- Neuroscience and Music Perception
- Autism Spectrum Disorder Research
- Neurofibromatosis and Schwannoma Cases
- Vestibular and auditory disorders
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Cardiac electrophysiology and arrhythmias
- Hemispheric Asymmetry in Neuroscience
- Immunotherapy and Immune Responses
- Innovation and Knowledge Management
- Polyomavirus and related diseases
- Hypothalamic control of reproductive hormones
- Quality and Management Systems
- Pain Management and Treatment
- Neurological disorders and treatments
- HIV-related health complications and treatments
Cincinnati Children's Hospital Medical Center
2013-2025
University of Cincinnati
2011-2023
Deakin University
2021
Virginia Tech
2020
Mississippi State University
2020
Tennessee Technological University
2016-2020
Kennedy Krieger Institute
2019
National Institute of Neurological Disorders and Stroke
1987-2019
Johns Hopkins Medicine
2019
Johns Hopkins University
2019
<h3>Objective</h3> Compared to typically developing (TD) peers, children with attention-deficit/hyperactivity disorder (ADHD) consistently demonstrate impaired transcranial magnetic stimulation (TMS)-evoked short interval cortical inhibition (SICI) of motor evoked potentials (MEPs) in resting cortex (M1). To determine whether perturbed M1 physiology also reflects clinically relevant behavioral dysfunction, we evaluated during a cognitive control task taxing response selection/inhibition....
Background: Although single- and paired-pulse (sp/pp) transcranial magnetic stimulation (TMS) studies are considered minimal risk in adults children, the safety profile for theta-burst TMS (TBS) is unknown. Objective: In this comparative analysis, we explored rate, severity, specific symptoms of TMS-related adverse effects (AEs) between sp/ppTMS TBS subjects ages 6 18 years. Method: Data from 165 participants 2009-2014 were analyzed. Assessment AEs was performed based on baseline post-TMS...
Abstract Objective The aim of this study was to identify a quantitative, brain‐based measure reflecting impaired response inhibition in children with attention‐deficit/hyperactivity disorder (ADHD). Methods In cross‐sectional study, we used transcranial magnetic stimulation (TMS) evoke potentials hand muscle during both simple reaction time and task 8‐to‐12‐year‐old children, 41 ADHD (42% girls, 76% white, mean age 10.3 years) 38 typically developing controls (53% 74% 9.8 years). We...
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral therapy (cART) are not clear. We obtained LN biopsies before and 10 14 days after trivalent seasonal influenza immunization from healthy controls (HCs) volunteers cART investigate CD4+ T follicular helper (Tfh) B by flow cytometry quantitative imaging...
In the course of human immunodeficiency virus infection or related simian (SIV), progression to AIDS is associated with high burdens in blood. How burden bloodstream tissue reservoirs was addressed an animal model rhesus macaques infected SIV. situ hybridization and quantitative image analysis were used quantitate burden. Animals who developed had levels production storage lymphoid evidence productive macrophages nervous system. With approach described, it should be possible design assess...
ABSTRACT Background Individuals with Tourette syndrome (TS) often report that they express tics as a means of alleviating the experience unpleasant sensations. These sensations are perceived an urge to act and referred premonitory urges. Premonitory urges have been focus recent efforts develop interventions reduce tic expression in those TS. Objective The aim this study was examine contribution brain γ‐aminobutyric acid (GABA) glutamate levels right primary sensorimotor cortex (SM1),...
Theta-burst stimulation (TBS) is a lower intensity, high-frequency repetitive transcranial magnetic technique developed recently for quantifying and modulating cerebral cortical function. Nearly all published studies have involved adults. The aim of this study was to obtain safety data as basis evaluating potential risks versus benefits TBS research in children.Forty participants under 18 years: 16 with Tourette syndrome (five females, 11 males; mean age 12y, SD 2y 10mo) 24 typically...
Abstract Tourette syndrome (TS) is a childhood-onset disorder in which tics are often preceded by premonitory sensory urges. More severe urges correlate with worse and can render behavioral therapies less effective. The supplementary motor area (SMA) prefrontal region believed to influence tic performance. To determine whether cortical physiological properties tics, we evaluated, 8–12-year-old right-handed TS children (n = 17), correlations of urge severity scores compared both excitability...
To compare transcranial magnetic stimulation (TMS)-derived measures of primary motor cortex (M1) physiology between children with and without Tourette syndrome, to dimensionally analyze TMS syndrome-related symptom severity.We used a cross-sectional experimental design. Sixty 8- 12-year-old participated (30 syndrome: three females, mean age 10 years months, standard deviation [SD] 1 year 3 months; 30 typically developing children: seven 7 SD months). In the group 15 (one female, 11 months)...
Functional impairment is an important factor in Tic Disorder treatment decisions. We evaluated the mini Child Tourette Syndrome Impairment Scale (mini-CTIM) for correlation with symptom severity and association interventions. A total of 61 randomly selected tic encounters were retrospectively analyzed mini-CTIM scores compared between patients who received those did not. Regression models identified factors associated Mini-CTIM-tic correlated mini-CTIM-non-tic attention-deficit hyperactivity...
Abstract The stop-signal paradigm has become ubiquitous in investigations of inhibitory control. Tasks inspired by the paradigm, referred to as tasks, require participants make responses on go trials and inhibit those when presented with a stop trials. Currently, most popular version task is ‘choice-reaction’ variant, where choice responses, but must stop-signal. An alternative choice-reaction variant ‘anticipated response inhibition’ task. In anticipated inhibition are required planned that...
Fourteen healthy children (13.8 ± 2.2 years, range 10-16; M:F = 5:9) received 30 Hz intermittent theta burst transcranial magnetic stimulation (iTBS) with a intensity of 70% resting motor threshold (RMT) total 300 (iTBS300) pulses. All volunteers were free neurologic, psychiatric and serious medical illnesses, not taking any neuropsychiatric medications, did have contraindications to stimulation. Changes in the mean amplitudes motor-evoked potentials from baseline following iTBS expressed as...
Abstract Limited data are available regarding the impact of coronavirus disease 2019 (COVID-19) pandemic on adolescents with Tourette syndrome (TS). We sought to compare sex differences in tic severity experienced by before and during COVID-19 pandemic. extracted from electronic health record retrospectively reviewed Yale Global Tic Severity Scores (YGTSS) (ages 13 through 17) TS presenting our clinic (36 months) (24 A total 373 unique adolescent patient encounters (prepandemic: 199;...
We aimed to compare tic- and non-tic-related impairment experienced by adolescent girls boys (ages 13 through 17) with Tourette syndrome associations age. extracted from the electronic health record child parental responses mini-Child Syndrome Impairment Scale (mini-CTIM) other questionnaire data reflective of adolescents presenting our clinic over a 12-month period. identified total 132 (49 female, 83 male) unique encounters. Mini-CTIM scores did not differ significantly between genders....
Abstract Background and purpose We analyzed the association of neuropsychological outcomes after epilepsy surgery with intracranial electrode type (stereo electroencephalography [SEEG] subdural electrodes [SDE]), electrical stimulation mapping (ESM) speech/language. Methods Drug‐resistant patients who underwent comprehensive evaluation before 1 year were included. SEEG SDE subgroups matched by age, handedness, operated hemisphere, seizure freedom. Postsurgical (adjusted for presurgical...
Clinical trials in children with attention-deficit hyperactivity disorder (ADHD) show variability behavioral responses to the selective norepinephrine reuptake inhibitor atomoxetine. The objective of this study was determine whether transcranial magnetic stimulation–evoked short interval cortical inhibition might be a biomarker predicting, or correlating with, clinical atomoxetine response. At baseline and after 4 weeks treatment 7- 12-year-old ADHD, stimulation measured, blinded...
Abstract Attention-deficit/hyperactivity disorder, the most prevalent developmental disorder in childhood, is a biologically heterogenous condition characterized by impaired attention and impulse control as well motoric hyperactivity anomalous motor skill development. Neuropsychological testing often demonstrates impairments motivation reward-related decision making attention-deficit/hyperactivity believed to indicate dysfunction of dopamine reward pathway. Development reliable,...