A5001406846- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Vagus Nerve Stimulation Research
- Neural dynamics and brain function
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Advanced MRI Techniques and Applications
- Genomics and Rare Diseases
- Glycogen Storage Diseases and Myoclonus
- Pharmaceutical studies and practices
- Infectious Encephalopathies and Encephalitis
- Tuberous Sclerosis Complex Research
- Anesthesia and Sedative Agents
- Congenital heart defects research
- Fetal and Pediatric Neurological Disorders
- Oral and gingival health research
- Sleep and Wakefulness Research
- Folate and B Vitamins Research
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2015-2025
University of Cincinnati Medical Center
2015-2025
Children's Hospital of Philadelphia
2015-2023
University of Pennsylvania
2015-2023
Hospital for Sick Children
2018-2021
SickKids Foundation
2021
University of Toronto
1991-2021
Danat Al Emarat Women & Children’s Hospital
2021
Hospital San Borja Arriarán
2020
The optimal pharmacologic treatment for early convulsive status epilepticus is unclear.
Treatment delay for seizures can lead to longer seizure duration. Whether treatment is associated with major adverse outcomes, such as death, remains unknown. To evaluate whether untimely first-line benzodiazepine unfavorable short-term outcomes. This multicenter, observational, prospective cohort study included 218 pediatric patients admitted between June 1, 2011, and July 7, 2016, into the 11 tertiary hospitals in United States within Pediatric Status Epilepticus Research Group. Patients,...
To describe the time elapsed from onset of pediatric convulsive status epilepticus (SE) to administration antiepileptic drug (AED).This was a prospective observational cohort study performed June 2011 2013. Pediatric patients (1 month-21 years) with SE were enrolled. In order timing AED during all stages SE, we restricted our population who failed 2 or more classes needed continuous infusions terminate SE.We enrolled 81 (44 male) median age 3.6 years. The first, second, and third doses...
Summary Purpose: Intravenous lorazepam is considered the drug of first choice for control acute convulsive seizures. However, resource or personnel constraints necessitate study alternative routes and medications. This compared efficacy adverse effects intranasal versus intravenous in children aged 6–14 years who presented with Methods: was a randomized open‐label conducted at an Indian hospital from August 2008 to April 2009. One hundred forty‐one consecutive convulsing emergency room were...
Objective: We describe the development and evaluation of a system that uses machine learning natural language processing techniques to identify potential candidates for surgical intervention drug-resistant pediatric epilepsy. The data are comprised free-text clinical notes extracted from electronic health record (EHR). Both known outcomes EHR manual chart annotations provide gold standards patient's status. following hypotheses then tested: 1) methods can epilepsy surgery as well physicians...
Abstract Objective Through international collaboration, we evaluated the phenotypic aspects of a multiethnic cohort KCNT1‐related epilepsy and explored genotype‐phenotype correlations associated with frequently encountered variants. Methods A cross‐sectional analysis children harboring pathogenic or likely KCNT1 variants was completed. Children one two more common recurrent were compared rest for presence particular characteristics. Results Twenty‐seven (15 males, mean age = 40.8 months)...
Tuberous sclerosis complex (TSC) with medically refractory epilepsy is characterized by multifocal brain abnormalities, traditionally indicating poor surgical candidacy. This single-center, retrospective study appraised seizurerelated, neuropsychological, and other outcomes of resective surgery in TSC patients epilepsy, analyzed predictors for these outcomes.Patients multilesional who underwent between 2007 2012 were identified from an electronic database. All multimodality noninvasive...
To describe pediatric patients with convulsive refractory status epilepticus in whom there is intention to use an IV anesthetic for seizure control.Two-year prospective observational study evaluating (age range, 1 mo 21 yr) not responding two antiepileptic drug classes and treated continuous infusion of agent.Nine hospitals the United States.In a cohort 111 (median age, 3.7 yr; 50% male), 54 (49%) underwent treatment.The median (interquartile range) ICU length stay was 10 (3-20) days. Up...
Abstract Objective We aimed to characterize the clinical profile and outcomes of new onset refractory status epilepticus (NORSE) in children, investigated relationship between fever (SE). Methods Patients with SE (RSE) June 1, 2011 October 2016 were prospectively enrolled pSERG (Pediatric Status Epilepticus Research Group) cohort. Cases meeting definition NORSE classified as "NORSE known etiology" or unknown etiology." Subgroup analysis etiology was completed based on presence time...
<h3>Objective:</h3> Gingival overgrowth is an important adverse effect of phenytoin (PHT) therapy, occurring in about half the patients. This study aimed to evaluate oral folic acid supplementation (0.5 mg/day) for prevention PHT-induced gingival (PIGO) children with epilepsy aged 6–15 years on PHT monotherapy 6 months. <h3>Methods:</h3> was a randomized, double-blind, placebo-controlled trial conducted at tertiary level hospital from May 2008 June 2009. Children started within last 1 month...
<h3>Objective</h3> To identify factors associated with treatment delays in pediatric patients convulsive refractory status epilepticus (rSE). <h3>Methods</h3> This prospective, observational study was performed from June 2011 to March 2017 on (1 month 21 years of age) rSE. We evaluated potential increased a Cox proportional hazards model. <h3>Results</h3> studied 219 (53% males) median (25th–75th percentiles [p<sub>25</sub>–p<sub>75</sub>]) age 3.9 (1.2–9.5) whom rSE started out hospital...
The predictive value of intraoperative electrocorticography (ECoG) in pediatric epilepsy surgery is unknown. In a population children undergoing ECoG followed typically by invasive extraoperative monitoring (IEM) and resection, we aimed to determine the relationship between frequent abnormalities seizure onset zone outcome after resection.We retrospectively identified 103 with preresection sufficient technical quality. records were scored based on electrode location frequency, blinded...
Despite technological and interpretative advances, the non-invasive modalities used for pre-surgical evaluation of patients with drug-resistant epilepsy (DRE), fail to generate a concordant anatomo-electroclinical hypothesis location seizure onset zone in many patients. This requires chronic monitoring intracranial electroencephalography (EEG), which facilitates better localization zone, allows functional significance cortical regions-of-interest by electrical stimulation mapping (ESM)....