A5058311554- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical Economics and Policy
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Drug Transport and Resistance Mechanisms
- Hemoglobinopathies and Related Disorders
- Meta-analysis and systematic reviews
- Ion channel regulation and function
- Cardiac Arrest and Resuscitation
- Tuberous Sclerosis Complex Research
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
Boston Medical Center
2021-2025
Boston University
2013-2025
Universitat de Barcelona
2014-2023
Hospital Sant Joan de Déu Barcelona
2014-2023
Case Western Reserve University
2022
Nationwide Children's Hospital
2015-2021
Mayo Clinic
2021
University of Colorado Anschutz Medical Campus
2021
Summary Purpose To examine patterns of use, efficacy, and safety intravenous ketamine for the treatment refractory status epilepticus ( RSE ). Methods Multicenter retrospective review medical records electroencephalography EEG ) reports in 10 academic centers North America Europe, including 58 subjects, representing 60 episodes that were identified between 1999 2012. Seven occurred after anoxic brain injury. Key Findings Permanent control was achieved 57% (34 60) episodes. Ketamine felt to...
Treatment delay for seizures can lead to longer seizure duration. Whether treatment is associated with major adverse outcomes, such as death, remains unknown. To evaluate whether untimely first-line benzodiazepine unfavorable short-term outcomes. This multicenter, observational, prospective cohort study included 218 pediatric patients admitted between June 1, 2011, and July 7, 2016, into the 11 tertiary hospitals in United States within Pediatric Status Epilepticus Research Group. Patients,...
We aimed to determine the incidence of electrographic seizures in children pediatric intensive care unit who underwent EEG monitoring, risk factors for seizures, and whether were associated with increased odds mortality.Eleven sites North America retrospectively reviewed a total 550 consecutive units monitoring. collected data on demographics, diagnoses, clinical mental status at onset, background, interictal epileptiform discharges, length stay, in-hospital mortality.Electrographic occurred...
Graph theory has been recently introduced to characterize complex brain networks, making it highly suitable investigate altered connectivity in neurologic disorders. A current model proposes autism spectrum disorder (ASD) as a developmental disconnection syndrome, supported by converging evidence both non-syndromic and syndromic ASD. However, the effects of abnormal on network properties have not well studied, particularly To close this gap, functional networks electroencephalographic (EEG)...
To compare the cost-effectiveness of genetic testing strategies in patients with epilepsy unknown etiology.This meta-analysis and study compared involving 3 tests: chromosomal microarray (CMA), panel (EP) deletion/duplication testing, whole-exome sequencing (WES) a model, using "no testing" as point comparison.Twenty studies provided information on diagnostic yield CMA (8 studies), EP (9 WES (6 studies). The was highest for WES: 0.45 (95% confidence interval [CI]: 0.33-0.57) (0.32 [95% CI:...
Summary We reviewed 37 studies reporting long‐term outcomes after a status epilepticus (SE) episode in pediatric and adult populations. Study design, length of follow‐up, outcome measures, domains investigated (mortality, SE recurrence, subsequent epilepsy, cognitive outcome, functional or quality life), predictors are summarized. Despite heterogeneity the design prior studies, overall risk poor is high both children adults. Etiology main determinant effect age duration often difficult to...
To describe the time elapsed from onset of pediatric convulsive status epilepticus (SE) to administration antiepileptic drug (AED).This was a prospective observational cohort study performed June 2011 2013. Pediatric patients (1 month-21 years) with SE were enrolled. In order timing AED during all stages SE, we restricted our population who failed 2 or more classes needed continuous infusions terminate SE.We enrolled 81 (44 male) median age 3.6 years. The first, second, and third doses...
The terms "electrical status epilepticus during sleep (ESES)" and "continuous spikes waves (CSWS)" have been used interchangeably when referring to related but different concepts. In addition, the quantification of epileptiform activity has not standardized, approaches used. aim this study was evaluate extent which pediatric neurologists epileptologists use a homogeneous terminology conceptualization in CSWS ESES characterize current understanding these conditions.
Continuous spikes and waves during sleep (CSWS) is an epileptic encephalopathy characterized in most patients by (1) difficult to control seizures, (2) interictal epileptiform activity that becomes prominent leading electroencephalogram (EEG) pattern of electrical status epilepticus (ESES), (3) neurocognitive regression. In this paper, we will summarize current epidemiological, clinical, EEG knowledge on CSWS provide suggestions for treatment. typically presents with seizures around 2-4...
The multicenter National Infantile Spasms Consortium prospective cohort was used to compare outcomes and phenotypic features of patients with infantile spasms without hypsarrhythmia.Patients aged 2 months years were enrolled prospectively new-onset spasms. Treatment choice categorization hypsarrhythmia determined clinically at each site. Response therapy defined as resolution clinical (and if present) relapse 3 after initiation.Eighty-two percent had hypsarrhythmia, but this not associated...
To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent electrical status epilepticus sleep either or without prominent sleep-potentiated epileptiform activity (PSPEA).We performed case-control study enrolled 1) features sleep, 2) ≥1 brain MRI scan, 3) overnight EEG recording. We quantified using spike percentage, percentage 1-second bins tracing containing at least 1 spike. PSPEA was present when during non-REM ≥50% than...
Summary Purpose: Currently, in continuous spikes and waves during sleep (CSWS) there is a lack of systematic assessments the clinically relevant stages evolution electroencephalographic features. The aim this study to describe over time clinical features CSWS. Methods: We enrolled patients from our video‐electroencephalography (EEG) monitoring unit with CSWS overnight EEG studies at least one assessment per year minimum period 3 years. studied presentation calculated (1) spike‐wave...
To describe pediatric patients with convulsive refractory status epilepticus in whom there is intention to use an IV anesthetic for seizure control.Two-year prospective observational study evaluating (age range, 1 mo 21 yr) not responding two antiepileptic drug classes and treated continuous infusion of agent.Nine hospitals the United States.In a cohort 111 (median age, 3.7 yr; 50% male), 54 (49%) underwent treatment.The median (interquartile range) ICU length stay was 10 (3-20) days. Up...
To identify factors associated with in-hospital mortality in neonates and children undergoing continuous electroencephalography (cEEG) monitoring the intensive care unit (ICU).We performed a retrospective observational study patients from birth to 21 years of age who underwent clinically indicated cEEG ICU 2011 2013. The main outcome measure was mortality.Six-hundred twenty-five (54.2% male) met eligibility criteria, whom 211 were (55% male, 24.8% premature) 414 pediatric (53.9% male)....