A5000864460- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Intensive Care Unit Cognitive Disorders
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Autoimmune Neurological Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Neurological disorders and treatments
- Non-Invasive Vital Sign Monitoring
- Neuroscience and Neural Engineering
- Advanced MRI Techniques and Applications
- Metabolism and Genetic Disorders
- Anesthesia and Sedative Agents
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Sepsis Diagnosis and Treatment
Yale University
2016-2025
Université Libre de Bruxelles
2016-2025
Erasmus Hospital
2016-2025
St. Antonius Ziekenhuis
2024
Medisch Spectrum Twente
2024
University of Twente
2016-2024
Amsterdam Neuroscience
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Michigan State University
2023
INTRODUCTION In the early 2000s, a subcommittee of American Clinical Neurophysiology Society (ACNS) set out to “standardize terminology periodic and rhythmic EEG patterns in critically ill aid future research involving such patterns.” The initial proposed was published 2005.1 This presented at many meetings on several continents, subjected multiple rounds testing interrater reliability, underwent revisions, then as an ACNS guideline 2013.2 Interrater agreement 2012 version (published 2013)...
The aims of this study were to determine the etiology, clinical features, and predictors outcome new-onset refractory status epilepticus. Retrospective review patients with epilepticus without etiology identified within 48 hours admission between January 1, 2008, December 31, 2013, in 13 academic medical centers. primary measure was poor functional at discharge (defined as a score >3 on modified Rankin Scale). Of 130 cases, 67 (52%) remained cryptogenic. most common etiologies autoimmune...
Summary Purpose To examine patterns of use, efficacy, and safety intravenous ketamine for the treatment refractory status epilepticus ( RSE ). Methods Multicenter retrospective review medical records electroencephalography EEG ) reports in 10 academic centers North America Europe, including 58 subjects, representing 60 episodes that were identified between 1999 2012. Seven occurred after anoxic brain injury. Key Findings Permanent control was achieved 57% (34 60) episodes. Ketamine felt to...
<h3>Importance</h3> Periodic and rhythmic electroencephalographic patterns have been associated with risk of seizures in critically ill patients. However, specific features that confer higher seizure remain unclear. <h3>Objective</h3> To analyze the association distinct characteristics periodic seizures. <h3>Design, Setting, Participants</h3> We reviewed recordings from 4772 adults 3 academic medical centers February 2013 to September 2015 performed a multivariate analysis determine...
To develop consensus-based recommendations for the management of adult and paediatric patients with NORSE/FIRES based on best evidence experience.
Abstract Objective To develop consensus‐based recommendations for the management of adult and pediatric patients with new‐onset refractory status epilepticus (NORSE)/febrile infection‐related epilepsy syndrome (FIRES) based on best available evidence expert opinion. Methods The Delphi methodology was followed. A facilitator group nine experts established who defined scope, users, suggestions recommendations. Following a review current literature, recommendation statements concerning...
The objective of this study was to investigate inflammation using cerebrospinal fluid (CSF) and serum cytokines/chemokines in patients with new-onset refractory status epilepticus (NORSE) better understand the pathophysiology NORSE its consequences.Patients (n = 61, including n 51 cryptogenic), subtype prior fever known as febrile infection-related epilepsy syndrome (FIRES), were compared other (RSE; 37), control without SE 52). We measured 12 or CSF samples multiplexed fluorescent...
The interpretation of critical care electroencephalography (EEG) studies is challenging because the presence many periodic and rhythmic patterns uncertain clinical significance. Defining significance these requires standardized terminology with high interrater agreement (IRA). We sought to evaluate IRA for final, published American Clinical Neurophysiology Society (ACNS)-approved version EEG (2012 version). Our evaluation included terms not assessed previously incorporated raters a broad...
Objective Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI key focus neurocritical care, but interventions carry risk and cannot be applied indiscriminately. Although retrospective studies have identified continuous electroencephalographic (cEEG) measures associated with DCI, no study has characterized the accuracy cEEG sufficient rigor to justify using it triage patients or clinical trials. We therefore prospectively...
<h3>Importance</h3> The increasing use of continuous electroencephalography (EEG) monitoring in the intensive care unit has led to recognition new EEG patterns that are unclear or unknown significance. <h3>Objective</h3> To describe an pattern, lateralized rhythmic delta activity (LRDA), encountered critically ill subjects and determine its clinical significance this setting. <h3>Design, Setting, Participants</h3> Retrospective review at academic medical center recordings, records, imaging...
Summary Objectives To study the incidence, spatial distribution, and signal characteristics of high frequency oscillations ( HFO s) outside epileptic network. Methods We included patients who underwent invasive evaluations at Yale Comprehensive Epilepsy Center from 2012 to 2013, had all major lobes sampled, localizable seizure onsets. Segments non–rapid eye movement (NREM) sleep prior first were analyzed. implemented a semiautomated process analyze with peak frequencies >80 Hz (ripples...
<h3>Objective:</h3> To evaluate the sensitivity of quantitative EEG (QEEG) for electrographic seizure identification in intensive care unit (ICU). <h3>Methods:</h3> Six-hour epochs chosen from 15 patients underwent transformation into QEEG displays. Each epoch was reviewed 3 formats: raw EEG, + raw, and QEEG-only. Epochs were also analyzed by a proprietary detection algorithm. Nine neurophysiologists EEGs to identify seizures serve as gold standard. other with experience evaluated formats,...