A5072171568- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- Innovations in Medical Education
- Herpesvirus Infections and Treatments
- Intensive Care Unit Cognitive Disorders
- Diversity and Career in Medicine
- Psychosomatic Disorders and Their Treatments
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Functional Brain Connectivity Studies
- ECG Monitoring and Analysis
- Traumatic Brain Injury Research
- Cellular transport and secretion
- Medical Education and Admissions
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Phytochemistry Medicinal Plant Applications
- Herbal Medicine Research Studies
- Multiple Sclerosis Research Studies
Medical University of South Carolina
2016-2024
Ralph H. Johnson VA Medical Center
2024
Massachusetts General Hospital
2022-2023
Harvard University
2022-2023
Children's Hospital of Philadelphia
2015-2023
Johns Hopkins University
2015-2023
University of Pennsylvania
2006-2023
University of California, San Francisco
2023
Yale University
2012-2022
University of California, Riverside
2022
<h3>Objectives:</h3> To determine continuous EEG (cEEG) patterns that may be unique to anti-NMDA receptor (NMDAR) encephalitis in a series of adult patients with this disorder. <h3>Methods:</h3> We evaluated the clinical and data 23 hospitalized anti-NMDAR who underwent cEEG monitoring between January 2005 February 2011 at 2 large academic medical centers. <h3>Results:</h3> Twenty-three median 7 (range 1−123) days monitoring. The length hospitalization was 44 2−200) days. Personality or...
Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status intensive care units. There significant variability patient populations undergoing CCEEG and technical specifications for performance.The Task Force of the American Clinical Neurophysiology Society developed expert consensus recommendations on use critically ill adults children.The panel recommends diagnosis nonconvulsive seizures, epilepticus, other paroxysmal events,...
The aims of this study were to determine the etiology, clinical features, and predictors outcome new-onset refractory status epilepticus. Retrospective review patients with epilepticus without etiology identified within 48 hours admission between January 1, 2008, December 31, 2013, in 13 academic medical centers. primary measure was poor functional at discharge (defined as a score >3 on modified Rankin Scale). Of 130 cases, 67 (52%) remained cryptogenic. most common etiologies autoimmune...
Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status intensive care units. There significant variability patient populations undergoing CCEEG and technical specifications for performance.The Task Force of the American Clinical Neurophysiology Society developed expert consensus recommendations on use critically ill adults children.The panel describes qualifications responsibilities personnel including neurodiagnostic...
<h3>Importance</h3> Seizure risk stratification is needed to boost inpatient seizure detection and improve continuous electroencephalogram (cEEG) cost-effectiveness. 2HELPS2B can address this need but requires validation. <h3>Objective</h3> To use an independent cohort validate the score develop a practical guide for its use. <h3>Design, Setting, Participants</h3> This multicenter retrospective medical record review analyzed clinical EEG data from patients 18 years or older with indication...
Seizures (SZs) and other SZ-like patterns of brain activity can harm the contribute to in-hospital death, particularly when prolonged. However, experts qualified interpret EEG data are scarce. Prior attempts automate this task have been limited by small or inadequately labeled samples not convincingly demonstrated generalizable expert-level performance. There exists a critical unmet need for an automated method classify SZs events with reliability. This study was conducted develop validate...
Objective: Sleep characteristics detected by electroencephalography (EEG) may be predictive of neurological recovery and rehabilitation outcomes after traumatic brain injury (TBI). We sought to determine whether sleep features were associated with greater access therapies better functional severe TBI. Methods: retrospectively reviewed records patients admitted TBI who underwent 24 or more hours continuous EEG (cEEG) monitoring within 14 days for elements ictal activity. Patient included...
The rapid expansion of the use continuous critical care electroencephalogram (cEEG) monitoring and resulting multicenter research studies through Critical Care EEG Monitoring Research Consortium has created need for a collaborative data sharing mechanism repository. authors describe development database incorporating American Clinical Neurophysiology Society standardized terminology monitoring. includes flexible report generation tools that allow daily clinical use.Key variables were...
The validity of brain monitoring using electroencephalography (EEG), particularly to guide care in patients with acute or critical illness, requires that experts can reliably identify seizures and other potentially harmful rhythmic periodic activity, collectively referred as "ictal-interictal-injury continuum" (IIIC). Previous interrater reliability (IRR) studies are limited by small samples selection bias. This study was conducted assess the identifying IIIC.
The practice of platelet (PLT) transfusions has been adopted into the standard clinical in many dengue-endemic countries. Because patients were found to have received unnecessary PLT transfusions, development guidelines for management dengue with thrombocytopenia become a necessity.An emergency department-based prospective observational study was conducted Martinique during outbreak adult presenting an acute febrile illness. Patients severe bleeding and/or who underwent invasive intensive...
Background: Data from neuropathologic studies of the frequency Alzheimer disease (AD) among African American persons conflict as to whether phenotype AD is identical in and white persons.Objectives: To examine clinical phenotypes individuals compare vascular burdens between persons.Design, Setting, Patients: Ten decedents who underwent brain autopsy at Washington University Alzheimer's Disease Research Center were matched for age, sex, Clinical Dementia Rating with 10 January 1, 1990,...
Therapeutic hypothermia is being utilized as a neuroprotective strategy in neonates, children, and adults. The most common indications are hypoxic ischemic encephalopathy neonates post cardiac arrest Electroencephalographic monitoring use increasing critical care units, sometimes component of therapeutic clinical pathways. Monitoring may detect non-convulsive seizures or status epilepticus, it provide prognostic information. We review data regarding for electroencephalographic neonatal,...
Purpose: Seizures in the intensive care unit are often subtle, and may have little or no clinical correlate. This study attempts to determine what features most strongly associated with presence of electrographic seizures on continuous EEG (cEEG) monitoring. Methods: A retrospective review for all patients who underwent cEEG monitoring between January 2003 March 2009 either characterization events altered mental status was performed. Clinical were categorized as (1) limb myoclonus/tremor,...
Antibodies to glutamic acid decarboxylase (GAD) have been associated with a host of neurological disorders including stiff person syndrome, cerebellar ataxia, limbic encephalitis, and epilepsy. Whether anti-GAD antibodies an etiological role in these or simply serve as disease markers is unclear. Here, we report case patient recurrent seizures, poorly responsive conventional treatment, antibodies. The was experiencing near daily seizures at the time presentation had marked improvement while...
Epilepsy monitoring unit (EMU) admissions provide a definitive diagnosis for approximately three-quarters of patients. However, many patients do not receive following EMU admission. Ambulatory EEG nondiagnostic was evaluated as means providing these patients.In this retrospective study, we performed chart review 62 pediatric and adult who had 72-hour ambulatory admission.In total, there were with subsequently underwent EEG. Mean age 33.8 (SD, 18.5) years. Forty-one (66.2%) female 46 (74.2%)...