A5078419836- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Health Literacy and Information Accessibility
- Neurological and metabolic disorders
- Healthcare Systems and Technology
- Advanced MRI Techniques and Applications
- Digital Mental Health Interventions
- Telemedicine and Telehealth Implementation
- Neuroscience and Neural Engineering
- Genomics and Rare Diseases
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Neurological disorders and treatments
- Electronic Health Records Systems
- Functional Brain Connectivity Studies
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- Healthcare Policy and Management
- Blind Source Separation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Mindfulness and Compassion Interventions
- Virtual Reality Applications and Impacts
Massachusetts General Hospital
2014-2023
Harvard University
2011-2023
William S. Middleton Memorial Veterans Hospital
2022
Beth Israel Deaconess Medical Center
2009-2020
The University of Texas Southwestern Medical Center
2020
Brigham and Women's Hospital
2020
Southwestern Medical Center
2020
University of Calgary
2020
Epilepsy Foundation
2020
American Academy of Neurology
2013-2019
It is the purpose of this review to critically consider and organize literature dealing with ephemeral electroencephalographic (EEG) pattern periodic lateralized epileptiform discharges (PLEDs). Although retrospective nature these studies limits their ability discuss accurately clinical pathophysiological aspects EEG entity, available data strongly emphasize stroke as dominant etiology its high association seizures. Recent evidence, particularly from functional neuroimaging studies, suggests...
Objective Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI key focus neurocritical care, but interventions carry risk and cannot be applied indiscriminately. Although retrospective studies have identified continuous electroencephalographic (cEEG) measures associated with DCI, no study has characterized the accuracy cEEG sufficient rigor to justify using it triage patients or clinical trials. We therefore prospectively...
To examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric relate clinical expression seizures AD.In this cross-sectional study, we performed 24-hour ambulatory EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD no history or risk factors for epilepsy (AD-NoEp), 15 late-onset related (AD-Ep). Two epileptologists blinded diagnosis visually reviewed all annotated...
<h3>Importance</h3> The validity of using electroencephalograms (EEGs) to diagnose epilepsy requires reliable detection interictal epileptiform discharges (IEDs). Prior interrater reliability (IRR) studies are limited by small samples and selection bias. <h3>Objective</h3> To assess the experts in detecting IEDs routine EEGs. <h3>Design, Setting, Participants</h3> This prospective analysis conducted 2 phases included as participants physicians with at least 1 year subspecialty training...
Seizures (SZs) and other SZ-like patterns of brain activity can harm the contribute to in-hospital death, particularly when prolonged. However, experts qualified interpret EEG data are scarce. Prior attempts automate this task have been limited by small or inadequately labeled samples not convincingly demonstrated generalizable expert-level performance. There exists a critical unmet need for an automated method classify SZs events with reliability. This study was conducted develop validate...
To determine whether 1) combined oral contraceptive (COC) use affects serum levels of valproate (VPA) as well lamotrigine (LTG) and 2) the naturally occurring high (mid-luteal) low (early-mid follicular) reproductive steroid level phases menstrual cycle might affect antiepileptic drug well.This investigation compared at two timepoints during a single in four groups women with epilepsy: 12 on VPA, VPA plus COC (VPA-COC), LTG, LTG (LTG-COC).Both were lower (p < 0.01) active than inactive pill...
<h3>Objective:</h3> To determine whether the absence of early epileptiform abnormalities predicts later seizures on continuous EEG monitoring hospitalized patients. <h3>Methods:</h3> We retrospectively reviewed 242 consecutive patients without a prior generalized convulsive seizure or active epilepsy who underwent lasting at least 18 hours for detection nonconvulsive evaluation unexplained altered mental status. The findings initial 30-minute screening EEG, subsequent recordings, and...
Quantitatively evaluate whether screening with compressed spectral arrays (CSAs) is a practical and time-effective protocol for assisting expert review of continuous EEG (cEEG) studies in hospitalized adults.Three neurophysiologists reviewed the reported findings first 30 minutes 118 cEEGs, then used CSA to guide subsequent ("CSA-guided review" protocol). Reviewers viewed 120 seconds raw data surrounding suspicious segments. The same performed independent page-by-page visual interpretation...
A woman who experienced postpartum cerebral infarction, brain edema, and death is described. Angiography implicated vasospasm as the primary etiology.
To evaluate published algorithms for the identification of epilepsy cases in medical claims data using a unique linked dataset with both clinical and data.
Introduction Mind-body medical approaches may ameliorate chronic disease. Stress reduction is particularly helpful, but face-to-face delivery systems cannot reach all those who might benefit. An online, 3-dimensional virtual world be able to support the rich interpersonal interactions required of this approach. In pilot study, we explore feasibility translating a stress program into an online setting and estimate effect size intervention. Methods Findings Domain experts in technology joined...
The validity of brain monitoring using electroencephalography (EEG), particularly to guide care in patients with acute or critical illness, requires that experts can reliably identify seizures and other potentially harmful rhythmic periodic activity, collectively referred as "ictal-interictal-injury continuum" (IIIC). Previous interrater reliability (IRR) studies are limited by small samples selection bias. This study was conducted assess the identifying IIIC.
We routinely monitor invasive neuroradiologic carotid balloon test occlusions with continuous polygraph and quantitative EEG along repeated detailed clinical examinations. Four of 17 consecutive cases showed changes during occlusion. In one instance, an immediate delta increase was accompanied by slurred speech aphasia. Another alpha attenuation without change. A third patient had significant change Nine the underwent permanent therapeutic occlusion as treatment intracerebral vascular...
Hoch and Ferguson discuss what they've learned from working with an online support group for people epilepsy.
To compare the expected quality-adjusted life-years (QALYs) in adult patients undergoing immediate vs deferred antiepileptic drug (AED) treatment after a first unprovoked seizure.
Stroke-associated seizures and epilepsy provide an excellent clinical model to study both acute hyperexcitability after stroke long-term tissue changes responsible for epileptogenic scar formation. The authors critically review the literature regarding seizures, define spectrum of association between seizures. Unfortunately, most studies performed in past were either retrospective heterogeneous or not designed address this important issue. Constant improvements advances technology, including...
Patients and their care givers have created an impressive array of online health resources. Can healthcare professionals tap into them? In 1994, as a part initiative by the department neurology Massachusetts General Hospital to develop promising new ways using information technology, we began study how patients with neurological concerns were To our surprise, found that thousands had already variety The support groups, each devoted single condition, especially intriguing. The...
Abstract Background: Little is understood about the evolution of structural and functional brain changes during course uncontrolled focal status epilepticus in humans. Methods: We serially evaluated treated a nine-year-old girl with refractory epilepticus. Long-term EEG monitoring, MRI, MRA, SPECT, intraoperative visualization affected cortex, neuropathological examination biopsy specimen were conducted over three year time span. Imaging correlated simultaneous treatment findings. Results:...
New technologies, such as online networking tools, offer innovative ways to engage patients in their diabetes care. Second Life (SL) is one virtual world that allows interact a 3D environment with peers and healthcare providers. This article presents framework demonstrates how applications within SL can be constructed meet the needs of diabetes, allowing them attend group visits, learn more about lifestyle changes, foster sense support emotional well-being. experiential approach education...