A5020261879- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Pharmacological Effects and Toxicity Studies
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- Pharmaceutical studies and practices
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neurological and metabolic disorders
- Schizophrenia research and treatment
- Diet and metabolism studies
- Cerebrospinal fluid and hydrocephalus
- Blind Source Separation Techniques
- Spinal Dysraphism and Malformations
- Moyamoya disease diagnosis and treatment
- Mental Health and Psychiatry
- Vagus Nerve Stimulation Research
- Neurological Complications and Syndromes
- Alcoholism and Thiamine Deficiency
- Global Health and Surgery
- Scoliosis diagnosis and treatment
- LGBTQ Health, Identity, and Policy
- ECG Monitoring and Analysis
Southwestern University
2021-2025
The University of Texas Southwestern Medical Center
2019-2024
Southwestern Medical Center
2020-2024
Brigham and Women's Hospital
2013-2020
Massachusetts General Hospital
2011-2020
Neurology, Inc
2020
Texas Neurology
2019
Medieval Academy of America
2016
Harvard University
2011-2014
Indiana University – Purdue University Indianapolis
2014
Epileptic seizures reflect a pathological brain state characterized by specific clinical and electrical manifestations. The proposed mechanisms are heterogeneous but united the supposition that epileptic activity is hypersynchronous across multiple scales, yet principled quantitative analyses of seizure dynamics space throughout entire ictal period rare. To more completely explore spatiotemporal interactions during seizures, we examined electrocorticogram data from population male female...
To examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric relate clinical expression seizures AD.In this cross-sectional study, we performed 24-hour ambulatory EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD no history or risk factors for epilepsy (AD-NoEp), 15 late-onset related (AD-Ep). Two epileptologists blinded diagnosis visually reviewed all annotated...
Abstract Our objective was to assess the ability of a smartphone-based electroencephalography (EEG) application, Smartphone Brain Scanner-2 (SBS2), detect epileptiform abnormalities compared standard clinical EEG. The SBS2 system consists an Android tablet wirelessly connected 14-electrode EasyCap headset (cost ~ 300 USD). and EEG were performed in people with suspected epilepsy Bhutan (2014–2015), recordings interpreted by neurologists. Among 205 participants (54% female, median age 24...
Decades of experience with intracranial recordings in patients epilepsy have demonstrated that seizures can occur deep cortical regions such as the mesial temporal lobes without showing any obvious signs seizure activity on scalp electroencephalogram. Predicated idea these are purely focal, currently, only way to detect 'scalp-negative seizures' is recordings. However, rarely performed epilepsy, and almost never outside context epilepsy. As such, little known about scalp-negative their role...
Epilepsy is a highly treatable condition for many people, but there are large treatment gaps with suboptimal seizure control in minoritized groups. The sexual and gender minority (SGM) community at risk health disparities, yet the burden of epilepsy this not known.
Introduction: This study examines the usability and comfort of a behind-the-ear seizure detection device called brain (BrainSD) that captures ictal electroencephalogram (EEG) data using four scalp electrodes. Methods: is feasibility study. Thirty-two patients admitted to level 4 Epilepsy Monitoring Unit were enrolled. The subjects wore BrainSD standard 21-channel video-EEG simultaneously. Epileptologists analyzed EEG signals collected by validated it confirm its accuracy. A poststudy survey...
A 61-year-old woman presented with acute bilateral hearing loss followed by vague but visual disturbances, nonvertiginous dizziness, and confusion. She also reported a recent 40-pound weight 1 month of persistent nausea vomiting, all which were attributed to diabetic gastroparesis; an extensive gastrointestinal evaluation (CT abdomen, gastric emptying study, esophagogastroduodenoscopy, colonoscopy) was unremarkable. Medical history notable for atrial fibrillation, diabetes mellitus, obesity,...
Epilepsy patients with mesial temporal sclerosis (MTS) on imaging who are drug-resistant usually undergo epilepsy surgery without previous invasive evaluation. However, up to one-third of not seizure-free after surgery. Prior studies have identified risk factors for surgical failure, but it is unclear if they associated bilateral or discordant seizure onset.
A 73-year-old man with benign prostatic hypertrophy, but no history of hypertension, presented acute urinary retention and severe headache followed by sudden loss vision.
Mesial temporal lobe epilepsy (MTLE) usually responds well to surgical treatment, although in non-lesional cases up 50% of patients experience seizure relapse. The possibility bilateral independent onset should be considered as a reason for surgery failure. In cohort 177 who underwent invasive presurgical evaluation with stereo-tactically placed electrodes two level four centers, 29 had MTLE. Invasive results are described. Among MRI and mesial recorded during stereo-EEG (SEEG) evaluation,...
Due to the coronavirus disease 2019 (COVID-19) pandemic, state of Texas-limited elective procedures conserve beds and personal protective equipment (PPE); therefore, between March 22 May 18, 2020, admission epilepsy monitoring unit (EMU) was limited only urgent emergent cases. We evaluated clinical characteristics outcomes these patients who were admitted EMU. Nineteen (one patient twice) with average age 36.26 years (11 female) length stay 3 days (range: 2–9 days). At least one event...
Decision algorithms are developed that use periods of intracranial non-seizure (interictal) EEG to localize epileptogenic networks. Depth and surface recordings considered from 5 6 patients respectively. The proposed combine spectral multivariate statistics in a decision-theoretic framework automatically delineate the seizure onset area. In case depth recordings, we apply standard binary classification algorithms, including linear quadratic discriminative analysis. For novel decision...
<h3>Objective:</h3> We aim to compare effects of thalamic Deep Brain Stimulator (DBS) and responsive neurostimulator (RNS) device therapy on seizure burden in drug-resistant epilepsy patients. <h3>Background:</h3> Intractable unamenable cortical resection is often treated with a device, either RNS or DBS provides intracranial stimulation. The devices are thought reduce frequency by reducing synchronization activity. more localized stimulation while the does this stimulating anterior nucleus...
Objective: To assess the occurrence and predictors of epileptiform EEG abnormalities in people with epilepsy at a national referral clinic lower income country without neurologists or routine neurological services. Background: Low low-middle countries - such as Bhutan carry heavy burden epilepsy, but role EEGs these settings is not well characterized. Methods: Participants any age who had seizures suspected were recruited on "first come, first served" basis Jigme Dorji Wangchuck National...
Objective: To introduce the concept of epilepsy management gap. Background: The treatment gap implies that administering antiepileptic drugs (AEDs) is a sufficient measure care. We propose to capture PWE who may take AEDs but continue incur risk or experience suboptimal management. Methods: PWE in Bhutan (National Referral Hospital, 2014-2015) completed clinical questionnaire, Quality Life Epilepsy inventory (QOLIE-31), and an electroencephalogram (EEG). Management was proportion...
Objective: To assess the Smartphone Brain Scanner-2 (SBS2)'s ability to detect abnormal and epileptiform cortical discharges compared standard electroencephalogram (EEG) among people with epilepsy (PWE) in Bhutan. Background: The SBS2 is a software application, utilizing 14-lead headset connected wirelessly an Android device. Portable, easily operated, low-cost (<500USD per device), may aid diagnosis of resource-limited settings. Methods: PWE or suspected seizures Bhutan underwent EEG (each...
Objective: To assess the Smartphone Brain Scanner-2 (SBS2)'s ability to detect abnormal and epileptiform cortical discharges compared standard electroencephalogram (EEG) among people with epilepsy (PWE) in Bhutan. Background: The SBS2 is a software application, utilizing 14-lead headset connected wirelessly an Android device. Portable, easily operated, low-cost (<500USD per device), may aid diagnosis of resource-limited settings. Methods: PWE or suspected seizures Bhutan underwent EEG (each...
Objective: To introduce the concept of epilepsy management gap. Background: The treatment gap implies that administering antiepileptic drugs (AEDs) is a sufficient measure care. We propose to capture PWE who may take AEDs but continue incur risk or experience suboptimal management. Methods: in Bhutan (National Referral Hospital, 2014-2015) completed clinical questionnaire, Quality Life Epilepsy inventory (QOLIE-31), and an electroencephalogram (EEG). Management was proportion participants...
<h3>Objective:</h3> Retrospectively review clinical outcomes in patients treated with resection or Laser interstitial Thermal Therapy (LiTT) immediately (≤ 90 days) after implantation of RNS. <h3>Background:</h3> Surgical and LiTT are standard treatments for refractory epilepsy, but these options can be limited by eloquent cortex seizure multifocality. Previous studies have suggested RNS may used conjunction resective surgery (RNS+R) (RNS+LiTT) as a new combination treatments. Besides...