A5015165314- Epilepsy research and treatment
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Psychosomatic Disorders and Their Treatments
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Schizophrenia research and treatment
- Genomics and Rare Diseases
- Neuroscience and Neural Engineering
- Neurological Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- ECG Monitoring and Analysis
- Psychiatric care and mental health services
- Spinal Dysraphism and Malformations
- Mental Health and Psychiatry
- Long-Term Effects of COVID-19
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Botulinum Toxin and Related Neurological Disorders
- Prenatal Screening and Diagnostics
The University of Texas Southwestern Medical Center
2015-2025
Southwestern Medical Center
2021-2024
Neurology, Inc
2020
Texas Neurology
2019
Nanotherapeutics (United States)
2018
Neurological Surgery
2015
The medial temporal lobe (MTL) encodes and recalls memories can be a predominant site for interictal spikes (IS) in patients with focal epilepsy. It is unclear whether memory deficits are due to IS the MTL producing transient decline. Here, we investigated subregions lateral cortex impact episodic encoding recall.Seventy-eight participants undergoing presurgical evaluation medically refractory epilepsy depth electrodes placed participated verbal free recall task. were manually annotated...
Background/Objectives: Temporal lobe epilepsy (TLE) responds well to surgical treatment, although a considerable percentage of patients experience seizure recurrence after resection. Relapse from the contralateral mesial temporal lobe, extratemporal mimicking TLE, or plus might account for failures. Methods: We included with pre-implantation hypothesis suggesting who underwent stereo-EEG (SEEG) evaluation at our institution and had an individual SEEG exploration paradigm least twelve...
Stereotactic EEG (SEEG) is gaining increasing popularity in the United States. Patients undergoing SEEG have unique challenges, and their needs are different compared with noninvasive cases. We aim to describe medical, nursing, other institutional practices of evaluations among tertiary referral (level IV) epilepsy centers accredited by National Association Epilepsy Centers.
Introduction: This study examines the usability and comfort of a behind-the-ear seizure detection device called brain (BrainSD) that captures ictal electroencephalogram (EEG) data using four scalp electrodes. Methods: is feasibility study. Thirty-two patients admitted to level 4 Epilepsy Monitoring Unit were enrolled. The subjects wore BrainSD standard 21-channel video-EEG simultaneously. Epileptologists analyzed EEG signals collected by validated it confirm its accuracy. A poststudy survey...
Epilepsy patients with mesial temporal sclerosis (MTS) on imaging who are drug-resistant usually undergo epilepsy surgery without previous invasive evaluation. However, up to one-third of not seizure-free after surgery. Prior studies have identified risk factors for surgical failure, but it is unclear if they associated bilateral or discordant seizure onset.
Abstract The optimal treatment for medically refractory epilepsy in Aicardi syndrome (AS) is still unclear. Palliative surgical treatment, including vagus nerve stimulation and corpus callosotomy, has therefore been used. There limited data on the role of resective surgery as a choice patients with AS. Here, we describe seizures, anatomo‐pathological findings, neurodevelopmental outcome palliative two children AS who had at Cleveland Clinic. related literature also reviewed. Case 1 left...
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Mesial temporal lobe epilepsy (MTLE) usually responds well to surgical treatment, although in non-lesional cases up 50% of patients experience seizure relapse. The possibility bilateral independent onset should be considered as a reason for surgery failure. In cohort 177 who underwent invasive presurgical evaluation with stereo-tactically placed electrodes two level four centers, 29 had MTLE. Invasive results are described. Among MRI and mesial recorded during stereo-EEG (SEEG) evaluation,...
Nodular heterotopia (NH) is a common cause of drug-resistant epilepsy. Only limited studies detail the treatment NH with laser interstitial thermal therapy and none analyze relation between epileptogenicity location.We retrospectively studied nine patients epilepsy who underwent stereoelectroencephalography subsequent surgery. in frontal lobes or along bodies lateral ventricles was classified as anterior NH. trigones, temporal occipital horns, posterior both locations diffuse Interictal...
Due to the coronavirus disease 2019 (COVID-19) pandemic, state of Texas-limited elective procedures conserve beds and personal protective equipment (PPE); therefore, between March 22 May 18, 2020, admission epilepsy monitoring unit (EMU) was limited only urgent emergent cases. We evaluated clinical characteristics outcomes these patients who were admitted EMU. Nineteen (one patient twice) with average age 36.26 years (11 female) length stay 3 days (range: 2–9 days). At least one event...
<h3>Objective:</h3> We aim to compare effects of thalamic Deep Brain Stimulator (DBS) and responsive neurostimulator (RNS) device therapy on seizure burden in drug-resistant epilepsy patients. <h3>Background:</h3> Intractable unamenable cortical resection is often treated with a device, either RNS or DBS provides intracranial stimulation. The devices are thought reduce frequency by reducing synchronization activity. more localized stimulation while the does this stimulating anterior nucleus...
Epilepsy surgery is superior to prolonged medical therapy in patients with drug-resistant focal epilepsy, but reports on epilepsy outcomes for a genetic etiology are limited, especially adults. This the first documented report of stereoelectroencephalography (SEEG) evaluation and resective outcome an adult patient related SCN8A mutation. We describe mutation which was reported as variant uncertain significance at time his pre-surgical reclassified likely pathogenic about 3 years after...
<h3>Objective:</h3> Retrospectively review clinical outcomes in patients treated with resection or Laser interstitial Thermal Therapy (LiTT) immediately (≤ 90 days) after implantation of RNS. <h3>Background:</h3> Surgical and LiTT are standard treatments for refractory epilepsy, but these options can be limited by eloquent cortex seizure multifocality. Previous studies have suggested RNS may used conjunction resective surgery (RNS+R) (RNS+LiTT) as a new combination treatments. Besides...
<h3>Objective:</h3> Our goal is to characterize EEG abnormalities in patients with psychogenic non epileptic seizures (PNES) and without epilepsy as well examine the relationship between imaging this cohort at a Level-4 Epilepsy center. <h3>Background:</h3> Prior studies have shown that <i>PNES higher rates of abnormalities; both epileptiform non-epileptiform compared general population. Studies noted changes PNES. For most these studies, studying were not primary goal. These older, had...
Objective: To demonstrate that stereo-electroencephalography (SEEG) may successfully replace evaluation with subdural electrodes (SDE) in the majority of patients who need invasive evaluations for epilepsy surgery. Background: SEEG is an informative and safe method medically intractable focal epilepsy. The goal to localize epileptogenic zone subsequent therapeutic surgical intervention, but appropriate balance between traditional grid methods not yet established. Design/Methods: We are...
May 9, 2019April 2019Free AccessCombined Treatment of Bilateral Periventricular Nodular Heterotopia with Laser Ablation and Neuropace Leads Placement after Stereo-EEG Evaluation (P5.5-033)Irina Podkorytova, Mark Agostini, Bradley Lega, Rodrigo Zepeda Garcia, Ryan Hays, Ghazala PervenAuthors Info & AffiliationsApril 2019 issue92 (15_supplement) Letters to the Editor
May 9, 2019April 2019Free AccessPatient selection and outcomes of placement the Neuropace Responsive Neurostimulator for treatment intractable epilepsy: a single center experience (P5.5-029)Mark Agostini, Sasha Alick, Rohit Das, Hina Dave, Marisara Dieppa, Kan Ding, jay harvey, … Show All , Ryan Hays, Ghazala Perven, Bradley Lega, irina podkorytova, Rodrigo Zepeda Garcia, vijay ram, Joseph Flay FewerAuthors Info & AffiliationsApril 2019 issue92 (15_supplement) Letters to Editor
Objective: To demonstrate that stereo-electroencephalography (SEEG) may successfully localize the epileptogenic zone in patients who have focal epilepsy related to schizencephaly. Background: The optimal treatment for medically refractory with schizencephaly is surgery, however there limited data role of SEEG evaluation localization this population. Design/Methods: Among 160 intractable underwent invasive pre-surgical stereo-electrodes our institution during five years, 3 had We describe...
Insular epilepsy is a great mimicker and can be mistaken for seizures originating from other areas of the brain or as nonepileptic spells. The semiology insular include, but not limited to, auditory illusions, paresthesias, gastric rising, laryngeal constriction, hyperkinetic movements. These arise both functions insula itself its extensive connections with regions brain. Noninvasive workup negative nonlocalizing because insula's location deep within lateral sulcus. Stereotactic EEG...
The object of this case series is to report the effectiveness and complication rates presurgical evaluation surgical treatment among elderly epilepsy patients in our clinic.We reviewed charts from 2016 2020 identified over age 55 years who underwent intracranial EEG, resection, device placement. We compared complications post-intervention outcomes 14 different patients.The mean was 63.6 ± 4.13 years, 6 (42.9 %) were female. 8 (57.1 evaluation; SEEG, 2 SDE 5/11 (45 reached seizure freedom...