A5058781612- Epilepsy research and treatment
- Connective tissue disorders research
- Neurological disorders and treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Pharmacological Effects and Toxicity Studies
- Psychosomatic Disorders and Their Treatments
- EEG and Brain-Computer Interfaces
- Respiratory Support and Mechanisms
- Aortic aneurysm repair treatments
- Hematopoietic Stem Cell Transplantation
- Aortic Disease and Treatment Approaches
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Advanced Proteomics Techniques and Applications
- Lysosomal Storage Disorders Research
- Airway Management and Intubation Techniques
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Single-cell and spatial transcriptomics
- Metabolomics and Mass Spectrometry Studies
- Complement system in diseases
- Neurogenetic and Muscular Disorders Research
- Autophagy in Disease and Therapy
- TGF-β signaling in diseases
Lund University
2014-2025
The University of Texas Southwestern Medical Center
2017-2025
Southwestern Medical Center
2017-2023
Gene Therapy Laboratory
2021
Neurology, Inc
2020
Queen Mary University of London
2015-2016
William Harvey Research Institute
2015-2016
Royal London Hospital
2015-2016
Johns Hopkins University
2012-2015
Howard Hughes Medical Institute
2015
Aneurysms affecting the aorta are a common condition associated with high mortality as result of aortic dissection or rupture. Investigations pathogenic mechanisms involved in syndromic types thoracic aneurysms, such Marfan and Loeys-Dietz syndromes, have revealed an important contribution disturbed transforming growth factor (TGF)-β signaling.This study sought to discover novel gene causing aneurysms order unravel underlying pathogenesis.We combined genome-wide linkage analysis, exome...
Cachectic muscle wasting is a frequent complication of many inflammatory conditions, due primarily to excessive catabolism. However, the pathogenesis and intervention strategies against it remain be established. Here, we tested hypothesis that Toll-like receptor 4 (TLR4) master regulator We demonstrate TLR4 activation by lipopolysac-charide (LPS) induces C2C12 myotube atrophy via up-regulating autophagosome formation expression ubiquitin ligase atrogin-1/MAFbx MuRF1. TLR4-mediated p38 MAPK...
Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence their efficacy and safety in the disorder. Unexpectedly, mice treated CCBs show accelerated expansion, rupture, premature lethality. This effect is both extracellular signal-regulated kinase (ERK1/2) dependent angiotensin-II type 1 receptor (AT1R) dependent. We have identified protein C beta (PKCβ) as a critical mediator of this pathway...
The transcription factor hepatic leukemia (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and thought to influence both HSC self-renewal leukemogenesis. However, the physiological role of HLF hematopoiesis function unclear. Here, we report that mice lacking Hlf are viable with essentially normal parameters, including an intact pool during steady-state hematopoiesis. In contrast, when challenged through transplantation, Hlf-deficient HSCs showed impaired ability reconstitute...
The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition B cell pool unperturbed hematopoiesis. Lineage tracing stratified murine based on timing output, revealing a substantial portion originated within restricted neonatal window. In addition B-1a cells, early-life time-stamped included clonally interrelated IgA plasma in gut bone marrow. These were actively maintained by memory...
Gaucher disease is caused by an inherited deficiency of the enzyme glucosylceramidase. Due to lack a fully functional enzyme, there progressive build-up lipid component glucosylceramide. Insufficient glucosylceramidase activity results in hepatosplenomegaly, cytopenias, and bone patients. Gene therapy represents future therapeutic option for patients unresponsive replacement lacking suitable marrow donor. By proof-of-principle experiments, we have previously demonstrated reversal symptoms...
Airway basal cells are crucial for regeneration of the human lung airway epithelium and believed to be important contributors chronic obstructive pulmonary disease (COPD) other disorders. To reveal how contribute discover novel therapeutic targets, these need further characterized. In this study, we optimized a flow cytometry-based cell sorting protocol primary dependent on size NGFR (nerve-growth factor receptor) expression. The population was found molecularly functionally heterogeneous,...
The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs cells. To quantify extent to which different cells impact in healthy diseased conditions, we developed a mass-spectrometry-based proteomics strategy infer tissue origin detected human plasma. We first constructed an extensive atlas 18 vascularized 8 most abundant cell types blood. was interfaced with previous RNA protein atlases objectively define proteome-wide protein-organ associations enable...
Temporally restricted expression of Lin28b promotes generation self-reactive B-1 cells early in life.
Abstract The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs cells. To quantify extent different cells contribute to composition, we developed a mass spectrometry-based proteomics strategy infer origin detected in human health disease. First, constructed an extensive atlas 18 vascularized most abundant cell types blood. Second, was interfaced with previous RNA/protein atlases objectively define wide protein-organ associations enable both inference...
Mesial temporal lobe epilepsy (MTLE) usually responds well to surgical treatment, although in non-lesional cases up 50% of patients experience seizure relapse. The possibility bilateral independent onset should be considered as a reason for surgery failure. In cohort 177 who underwent invasive presurgical evaluation with stereo-tactically placed electrodes two level four centers, 29 had MTLE. Invasive results are described. Among MRI and mesial recorded during stereo-EEG (SEEG) evaluation,...
Due to the coronavirus disease 2019 (COVID-19) pandemic, state of Texas-limited elective procedures conserve beds and personal protective equipment (PPE); therefore, between March 22 May 18, 2020, admission epilepsy monitoring unit (EMU) was limited only urgent emergent cases. We evaluated clinical characteristics outcomes these patients who were admitted EMU. Nineteen (one patient twice) with average age 36.26 years (11 female) length stay 3 days (range: 2–9 days). At least one event...
Cellular barcoding enables the dissection of clonal dynamics in heterogeneous cell populations through single lineage tracing. The labeling hematopoietic stem and progenitor cells (HSPCs) with unique heritable DNA barcodes, makes it possible to resolve donor heterogeneity terms differentiation potential bias at level, subsequent transplantation high-throughput sequencing. Furthermore, cellular allows for bona fide (HSCs) be defined based on functional rather than immunophenotypic parameters....
<h3>Objective:</h3> We aim to compare effects of thalamic Deep Brain Stimulator (DBS) and responsive neurostimulator (RNS) device therapy on seizure burden in drug-resistant epilepsy patients. <h3>Background:</h3> Intractable unamenable cortical resection is often treated with a device, either RNS or DBS provides intracranial stimulation. The devices are thought reduce frequency by reducing synchronization activity. more localized stimulation while the does this stimulating anterior nucleus...