A5020013064- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Adolescent and Pediatric Healthcare
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Childhood Cancer Survivors' Quality of Life
- Peripheral Neuropathies and Disorders
- Neurosurgical Procedures and Complications
- Pregnancy and Medication Impact
- Cerebrovascular and Carotid Artery Diseases
- Metabolism and Genetic Disorders
- Infectious Encephalopathies and Encephalitis
- Empathy and Medical Education
- Cellular transport and secretion
- Infant Development and Preterm Care
- Acute Ischemic Stroke Management
- Autoimmune Neurological Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- Innovations in Medical Education
- Occupational and Professional Licensing Regulation
- Vagus Nerve Stimulation Research
- Moyamoya disease diagnosis and treatment
Ottawa Hospital
2012-2025
University of Ottawa
2011-2025
Ottawa Hospital Research Institute
2019-2024
Deleted Institution
2023
Brigham and Women's Hospital
2015-2020
Massachusetts General Hospital
2016-2020
Boston Children's Hospital
2020
Harvard University
2016
In-Q-Tel
2016
Hôpital du Valais
2015
<h3>Importance</h3> Periodic and rhythmic electroencephalographic patterns have been associated with risk of seizures in critically ill patients. However, specific features that confer higher seizure remain unclear. <h3>Objective</h3> To analyze the association distinct characteristics periodic seizures. <h3>Design, Setting, Participants</h3> We reviewed recordings from 4772 adults 3 academic medical centers February 2013 to September 2015 performed a multivariate analysis determine...
Machado–Joseph disease (MJD), the most common dominantly inherited ataxia worldwide, is caused by a polyglutamine (polyQ) expansion in deubiquitinating (DUB) enzyme ataxin-3. Interestingly, MJD can present clinically with features of Parkinsonism. In this study, we identify parkin, an E3 ubiquitin-ligase responsible for familial form Parkinson's disease, as novel ataxin-3 binding partner. The interaction between and parkin direct, involves multiple domains greatly enhanced...
Objectives: We wanted to examine the extent which “neurophobia” exists among medical students and determine if students’ perceptions of neurology differ by year study while exploring factors that contribute development “neurophobia”. Methods: used a two-phase, sequential, mixed-methods explanatory design in this single centre study. Phase 1 involved collection analysis questionnaire administered first three years school. 2 focus groups subgroup who demonstrated evidence neurophobia 1....
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Abstract Objective Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy caused by SCN1A haploinsufficiency in the majority of cases. Caregivers adults with DS often complain about loss previously acquired skills. We set out to explore these perceptions determine whether abnormalities reported were detectable validated tests. also investigated possible correlations between symptoms, age, exposure sodium channel blockers (SCBs). Methods This cross‐sectional, multicenter...
We present a novel epilepsy fellow–driven transfer clinic model and discuss the challenges experienced in finding sustainability; this is timely as many pioneering transition clinics are dissolving across North America. The goal of was to improve patient care satisfaction, measured by post-visit telephone survey. Unfortunately, our proved unsustainable due several factors, broadly categorized (1) cultural-societal differences between pediatric adult health environments, (2) staffing issues,...
This report discusses a case of nonconvulsive status epilepticus, caused by cerebral amyloid angiopathy-related inflammation. Brain biopsy demonstrated angiopathy, with clinical and radiographic features indicative fluctuating inflammatory process. Immunomodulatory treatment pulse steroids resulted in rapid dramatic improvement. Cerebral inflammation should be considered the differential diagnosis new-onset seizures after age 40, when associated multifocal T2 hyperintensities petechial...
Epilepsy is most common in lower-income settings where access to electroencephalography (EEG) generally poor. A low-cost tablet-based EEG device may be valuable, but the quality and reproducibility of output are not established.Tablet-based was deployed a heterogeneous epilepsy cohort Republic Guinea (2018-2019), consisting tablet wirelessly connected 14-electrode cap. Participants underwent twice (EEG1 EEG2), separated by variable time interval. Recordings were scored remotely experts...
Tandem occlusions, characterized by the simultaneous presence of an intracranial large vessel occlusion and extracranial carotid artery stenosis or occlusion,1 pose a unique endovascular challenge.2 3 Typically, is result atherosclerotic plaque; however, dissections are also possible cause. It currently uncertain whether first approach should be employed.4 5 A new technique has been developed which allows for treatment both lesion.6 We describe variation this technique: stent retriever...
There are few data on adults living with tuberous sclerosis complex (TSC), most studies focusing pediatric populations. The objective of our study was to examine a large national cohort TSC, and describe the clinical characteristics these nature multidisciplinary care that they receive.Six Canadian medical centers collaborated in this study. Data were collected using standardized form, descriptive statistics used for analyses.Our included 181 definite TSC (mean age = 33.6 years [SD 13.7])....
This case report describes a 57-year-old man with hemochromatosis and panhypopituitarism who presented 6-month history of word-finding difficulty, short-term memory loss, rapidly cycling symptoms.
Introduction In donation after circulatory determination of death, death is declared 5 min arrest. This practice assumes, but does not explicitly confirm, permanent loss brain activity. While this assumption rooted a strong physiological rationale, paucity direct human data regarding temporal relationship between cessation activity and arrest during the dying process threatens public healthcare provider trust in deceased organ donation. Methods analysis cohort study, we will prospectively...