A5103036329- Infectious Diseases and Tuberculosis
- Orthopedic Infections and Treatments
- Spinal Dysraphism and Malformations
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Amoebic Infections and Treatments
- Pelvic and Acetabular Injuries
- Intracerebral and Subarachnoid Hemorrhage Research
- Medical Imaging and Analysis
- Artificial Intelligence in Healthcare and Education
- Management of metastatic bone disease
- Intracranial Aneurysms: Treatment and Complications
- Musculoskeletal Disorders and Rehabilitation
- Neurosurgical Procedures and Complications
- Case Reports on Hematomas
- Cardiac, Anesthesia and Surgical Outcomes
- Stroke Rehabilitation and Recovery
- Fire effects on ecosystems
- Traumatic Brain Injury and Neurovascular Disturbances
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Hip and Femur Fractures
- Nerve injury and regeneration
- Anatomy and Medical Technology
- Chemical Looping and Thermochemical Processes
Johannes Gutenberg University Mainz
2018-2025
University Medical Center of the Johannes Gutenberg University Mainz
2018-2025
LMU Klinikum
2025
Ludwig-Maximilians-Universität München
2025
Universitätsmedizin Göttingen
2022
Institut für Hygiene und Umwelt
2006
The aims of this study were to determine the etiology, clinical features, and predictors outcome new-onset refractory status epilepticus. Retrospective review patients with epilepticus without etiology identified within 48 hours admission between January 1, 2008, December 31, 2013, in 13 academic medical centers. primary measure was poor functional at discharge (defined as a score >3 on modified Rankin Scale). Of 130 cases, 67 (52%) remained cryptogenic. most common etiologies autoimmune...
Pyogenic spondylodiscitis presents significant diagnostic and therapeutic challenges. In Germany, a comprehensive understanding of its epidemiology inpatient management outcomes is limited, hindering the optimisation strategies. This study aimed to characterise evolving epidemiological trends pyogenic in concurrently evaluate strategies outcomes. We performed retrospective population-based cases Germany from 2005 2021, utilising data German Federal Statistical Office database. The parameters...
Pyogenic spondylodiscitis management often remains conservative without surgical intervention, yet the risk of spinal deformity under such therapy is unclear. This study explores progression in conservatively treated patients and identifies predictive factors for advancement. Retrospective cohort design with radiological data analysis from 59 pyogenic spondylodiscitis. Deformities were categorized into four types reflecting severity: Type 1 (progressive vertebral body edema/endplate...
Cerebral hypoperfusion in the first hours after subarachnoid haemorrhage (SAH) is a major determinant of poor neurological outcome. However, underlying pathophysiology only partly understood. Here we induced neutropenia C57BL/6N mice by anti-Ly6G antibody injection, SAH endovascular filament perforation, and analysed cerebral cortical perfusion with laser SPECKLE contrast imaging to investigate role neutrophils mediating during 24 h post-SAH. induction significantly increased intracranial...
OBJECTIVE The incidence of spondylodiscitis is rising across Europe, but the ideal treatment approach remains controversial. choice between conservative and surgical therapies ambiguous due to a lack consensus. This European survey aimed explore prevailing paradigms for primary spondylodiscitis. METHODS Spine neurosurgeons were invited through Association Neurosurgical Societies Section’s mailing list participate in an online featuring 7 case vignettes. Along with general management queries,...
BACKGROUND AND OBJECTIVES: Pyogenic spinal infections pose therapeutic challenges, with the optimal treatment approach remaining contentious. This study aimed to compare outcomes of conservative vs early surgical (SuT) modalities in primary pyogenic spondylodiskitis through an international cohort analysis. METHODS: A retrospective outcome analysis was conducted 392 patients from United Kingdom and Germany, treated between 2017 2022 spondylodiskitis. Patients were stratified by modality....
Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of vasospasm impaired perfusion neurological impairment in a murine model SAH. SAH was induced C57BL/6 mice by endovascular filament perforation. Vasospasm analyzed with microcomputed tomography, cortical laser SPECKLE contrast imaging, functional quantitative neuroscore. animals developed as significantly...
Abstract The incidence of fragility fractures the sacrum is increasing due to demographic changes. In this study, we introduce 3D-navigated monoportal percutaneous sacroiliac screw fixation (PSS) as a technical advancement for treating sacrum. We included all patients who underwent PSS were classified using Fragility Fractures Pelvis score (FFP). provide step-by-step illustration surgical technique. objective study was assess feasibility and safety investigated Forty-six (36 female, 10 male)...
The optimal operative approach for treating spinal infections remains a subject of debate. Corpectomy and Vertebral Body Replacement (VBR) have emerged as common modalities, yet data on their feasibility complication profiles are limited.
The Oswestry Spinal Risk Index (OSRI) was designed to predict life expectancy of patients presenting with spinal metastases. It integrates the most predictive items existing scores and is calculated using not more than two items: General condition primary tumor.The purpose this study externally validate OSRI in a large cohort compare it established scores.We retrospectively identified 211 consecutive surgical symptomatic We collected clinical radiographic data, such as Karnofsky Performance...
sample sizes have systematically analyzed the risk factors for TOLF.In present study, we retrospectively collected clinical data from 530 inpatients diagnosed with TOLF, summarized their demographic characteristics, and focused on relationship between body mass index (BMI) TOLF.The purpose of this study is to identify independent specifically association BMI TOLF.Materials Methods: A total 856 individuals consisting 326 controls without ossification spinal ligaments TOLF who underwent...
Postoperative seizures are a frequently occurring yet not well-understood complication in patients undergoing surgical treatment of chronic subdural haematomas (cSDHs). Therefore, we investigated and non-surgical risk factors that commonly considered causal provoking epileptic seizures, paying special attention to the intracranial course drain (SDD) configuration haematoma. Data with cSDH, were treated at our neurosurgical department between 2008 2014 analysed. Patients suffering from severe...