A5103064316- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Thermal Regulation in Medicine
- Sarcoidosis and Beryllium Toxicity Research
- Thermoregulation and physiological responses
- Venomous Animal Envenomation and Studies
- Peripheral Neuropathies and Disorders
- Anesthesia and Neurotoxicity Research
- Intracerebral and Subarachnoid Hemorrhage Research
Johannes Gutenberg University Mainz
2018-2023
University Medical Center of the Johannes Gutenberg University Mainz
2018
Philipps University of Marburg
2010
Development of vasogenic brain edema is a key event contributing to mortality after subarachnoid hemorrhage (SAH). The precise underlying mechanisms at the neurovascular level that lead disruption blood-brain barrier (BBB) are still unknown. Activation myosin light chain kinases (MLCK) may result in change endothelial cell shape and opening intercellular gap with subsequent vascular leakage. Male C57Bl6 mice were subjected endovascular perforation. Brain water content was determined by...
Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of vasospasm impaired perfusion neurological impairment in a murine model SAH. SAH was induced C57BL/6 mice by endovascular filament perforation. Vasospasm analyzed with microcomputed tomography, cortical laser SPECKLE contrast imaging, functional quantitative neuroscore. animals developed as significantly...