Abstract BACKGROUND AND IMPORTANCE: In contrast to cranial interventions, neuronavigation in spinal surgery is used few applications, not tapping into its full technological potential. We have developed a method preoperatively create virtual resection planes and volumes for osteotomies export 3-D operation plans navigation system controlling intraoperative visualization using surgical microscope's head-up display. The was Sawbone ® model of the lumbar spine, demonstrating feasibility with...

BACKGROUND AND OBJECTIVES: External ventricular drain (EVD) placement is a critical, lifesaving procedure in cranial neurosurgery, often performed manually using anatomical landmarks that vary between individuals. This study evaluates the efficacy of 3-dimensional (3D)–printed EVD training model designed to improve accuracy this procedure. METHODS: Computed tomography scans from 3 patients were used create 3D-printed head models with narrow, wide, and normal ventricles. Twenty-five...

Background: Airway Pressure Release Ventilation (APRV) is an alternate mode of ventilation in acute respiratory failure (ARF), but there inconsistent data to support its use over other modes ventilation. Because increased intrathoracic pressure for most the cycle, a negative impact APRV on intracranial (ICP) and cerebral perfusion (CPP) has been hypothesized. We evaluated effects ventilation, with particular attention ICP, CPP ICP-directed therapy, real-world cohort neuro-ICU patients....

Cerebral hypoperfusion in the first hours after subarachnoid haemorrhage (SAH) is a major determinant of poor neurological outcome. However, underlying pathophysiology only partly understood. Here we induced neutropenia C57BL/6N mice by anti-Ly6G antibody injection, SAH endovascular filament perforation, and analysed cerebral cortical perfusion with laser SPECKLE contrast imaging to investigate role neutrophils mediating during 24 h post-SAH. induction significantly increased intracranial...

Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of vasospasm impaired perfusion neurological impairment in a murine model SAH. SAH was induced C57BL/6 mice by endovascular filament perforation. Vasospasm analyzed with microcomputed tomography, cortical laser SPECKLE contrast imaging, functional quantitative neuroscore. animals developed as significantly...

Excessive or incorrect loading of lumbar spinal structures is commonly assumed as one the factors to accelerate degenerative processes, which may lead lower back pain. Accordingly, mechanics spine under medical conditions, such scoliosis spondylolisthesis, well-investigated. Treatments via both conventional therapy and surgical methods alike aim at restoring a "healthy" (or least pain-free) load distribution. Yet, surprisingly little known about inter-subject variability bearings within...

Background: Computed tomography angiography (CTA) is frequently used with computed perfusion imaging (CTP) to evaluate whether endovascular vasospasm treatment indicated for subarachnoid hemorrhage patients delayed cerebral ischemia. However, objective parameters CTA evaluation are lacking. In this study, we an automated, investigator-independent, digital method detect vasospasm, and evaluated the could predict need subsequent treatment. Methods: We retrospectively reviewed charts analyzed...

Three-dimensional (3D) printing technologies offer the possibility of visualizing patient-specific pathologies in a physical model correct dimensions. The can be used for planning and simulating critical steps surgical approach. Therefore, it is important that anatomical structures such as blood vessels inside tumor printed to colored not only on their surface, but throughout whole volume. During simulation this allows removal certain parts (e.g., with high-speed drill) revealing internally...

Abstract Cerebral hypoperfusion is a key factor for determining the outcome after subarachnoid hemorrhage (SAH). A subset of SAH patients develop neurogenic stress cardiomyopathy (NSC), but it unclear to what extent cerebral influenced by cardiac dysfunction SAH. The aims this study were examine association between function and perfusion in murine model identify electrocardiographic echocardiographic signs indicative NSC. We quantified cortical laser SPECKLE contrast imaging, myocardial...

Quantification of cerebral vasospasm after subarachnoid hemorrhage (SAH) is crucial in animal studies as well clinical routine. We have developed a method for computer-based volumetric assessment intracranial blood vessels from cross-sectional imaging data. Here we demonstrate the quantification micro computed tomography (micro-CT) data rodent SAH model and transferability approach to data.We obtained by performing an ex vivo micro-CT murine brains sham surgery or endovascular filament...

Lumbar spine biomechanics during the forward-bending of upper body (flexion) are well investigated by both in vivo and vitro experiments. In cases, experimentally observed relative motion vertebral bodies can be used to calculate instantaneous center rotation (ICR). The timely evolution ICR, centrode, is widely utilized for validating computer models thought serve as a criterion distinguishing healthy degenerative patterns. While induced physiological active structures (muscles), spinal...

Three-dimensional (3D) printing technologies offer the possibility of visualizing patient-specific pathologies in a physical model correct dimensions. The can be used for planning and simulating critical steps surgical approach. Therefore, it is important that anatomical structures such as blood vessels inside tumor printed to colored not only on their surface, but throughout whole volume. During simulation this allows removal certain parts (e.g., with high-speed drill) revealing internally...

Subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke. Cerebral vasospasm that occurs in the aftermath bleeding an important factor determining patient outcome and therefore frequently taken as study endpoint. However, small animal studies on SAH, quantification cerebral major challenge. Here, ex vivo method presented allows volumes entire vessel segments, which can be used objective measure to quantify vasospasm. In first step, endovascular casting vasculature performed using...

The surgical treatment of degenerative spondylolisthesis with accompanying spinal stenosis focuses mainly on decompression the canal or without additional fusion by means a dorsal spondylodesis. Currently, one main decision criterion for is presence instability in flexion and extension X-rays. In cases mild stable spondylolisthesis, optimal remains subject ongoing debate. There exist different opinions whether performing directly together has potential benefit patients constitutes...

A feasibility study.To develop a method based on the DICOM standard which transfers complex 3-dimensional (3D) trajectories and objects from external planning software to any navigation system for intraoperative guidance of spinal procedures.There have been many reports about systems with embedded solutions but only few how transfer data generated in software.Patients computerized tomography and/or magnetic resonance volume sets affected segments were imported Amira software, reconstructed...