A5086927005- Digital and Traditional Archives Management
- Historical Studies in Central America
- Migration, Policy, and Dickens Studies
- Artificial Intelligence Applications
- Metallurgical Processes and Thermodynamics
- Economic, financial, and policy analysis
- Law, logistics, and international trade
- Australian History and Society
- Banking Systems and Strategies
- Migration, Ethnicity, and Economy
- Digital Humanities and Scholarship
- Cooperative Studies and Economics
- Library Science and Information Systems
- Firm Innovation and Growth
- Vitamin C and Antioxidants Research
- Management, Economics, and Public Policy
- Archaeological Research and Protection
- Wine Industry and Tourism
- Radiomics and Machine Learning in Medical Imaging
- Scottish History and National Identity
- Radioactive element chemistry and processing
- Maritime and Coastal Archaeology
- Medical Imaging Techniques and Applications
- Chemical Synthesis and Characterization
- Private Equity and Venture Capital
University of Iowa
2016-2025
Seattle Children's Hospital
2025
Mitchell Institute
2025
Texas A&M University
2025
Utah State University
2025
Nova Southeastern University
2024
Galecto (Denmark)
2024
Royal Hospital for Children
2009-2023
Bendigo Hospital
2023
University of Iowa Holden Comprehensive Cancer Center
2006-2023
Markov chain Monte Carlo (MCMC) is the most widely used method of estimating joint posterior distributions in Bayesian analysis. The idea MCMC to iteratively produce parameter values that are representative samples from posterior. Unlike frequentist analysis where iterative model fitting routines monitored for convergence a single point, output distribution. Thus, specialized diagnostic tools needed setting. To this end, R package boa was created. This manuscript presents user's manual boa,...
In recent years, the terms machine learning, data science, and predictive modeling have become ubiquitous in nearly every discipline which analysis plays a central role. When first diving i...
Ketogenic diets are high in fat and low carbohydrates as well protein which forces cells to rely on lipid oxidation mitochondrial respiration rather than glycolysis for energy metabolism. Cancer (relative normal cells) believed exist a state of chronic oxidative stress mediated by The current study tests the hypothesis that ketogenic enhance radio-chemo-therapy responses lung cancer xenografts enhancing stress.Mice bearing NCI-H292 A549 were fed diet (KetoCal 4:1 fats:...
Exposure to high concentrations of radon progeny (radon) produces lung cancer in both underground miners and experimentally exposed laboratory animals. To determine the risk posed by residential exposure, authors performed a population-based, case-control epidemiologic study Iowa from 1993 1997. Subjects were female residents who had occupied their current home for at least 20 years. A total 413 cases 614 age-frequency-matched controls included final analysis. Excess odds calculated per 11...
Most recent experiments have indicated that distal pocket polarity rather than steric hindrance is the major factor governing distribution of FeCO stretching frequencies (νC-O, νFe-CO) in myoglobins and hemoglobins. Hydrogen bonding other polar interactions also been shown to play a key role regulating O2 CO binding. To quantify effects on νC-O, νFe-CO, ligand binding, we calculated electrostatic potential field distributions pockets 18 different mutants two wild-type forms recombinant pig...
Abstract Mutations in genes coding for succinate dehydrogenase (SDH) subunits are believed to contribute cancer and aging, but the mechanism this is unclear. Hamster fibroblasts expressing a mutation SDH subunit C (SDHC; B9) showed 3-fold increases dihydroethidine dichlorodihydrofluorescein (CDCFH2) oxidation indicative of increased steady-state levels O2·− H2O2, glutathione/glutathione disulfide (indicative oxidative stress), as well superoxide dismutase activity, relative parental B1...
Passive compliance (C) has been measured in 10 infants at 10--90 min after birth and a few days of life by recording mouth pressure airways occlusions end inspiration. From the slope expiratory flow-volume curve, passive time constant (tau) resistance (R = tau/C) have also computed. Examination changes C with curves indicates that end-expiratory volume is maintained above functional residual capacity both ages, but significantly more so (7.6 ml) than (3.5 ml). The (tau . R) shorter early age...
In the hamster tracheal epithelium, both vitamin A deficiency and multiple intratracheal instillations of benzo[a]pyrene-ferric oxide caused squamous metaplasia. By light microscopy, metaplasia without cell atypia by is morphologically similar to that carcinogen administration. However, significant differences at ultrastructural level were observed. Defects in basement membrane, enlarged nuclei with cytoplasmic invaginations, pleomorphic nucleoli restricted induced oxide.
Ketogenic diets are low in carbohydrates and high fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy. Relative normal cells, cancer believed exist under a condition chronic oxidative stress that is compensated by increases glucose metabolism generate reducing equivalents. In this study we tested the hypothesis ketogenic diet concurrent with radiation chemotherapy would be clinically tolerable locally advanced non-small cell lung (NSCLC)...
1. Selective hydrogenation, followed by fractional crystallization from a solvent, has been used to prepare cottonseed oil hard butter, very similar cocoa butter. 2. The new product differs somewhat in composition due an unavoidable content of iso-oleic acid. 3. Examination the micropenetration technique, standard solidification test, and means dilatometer, reveals minor physical differences between it 4. fat slightly longer plastic range than It supercools less strongly contracts upon...
The toxicity of pharmacologic ascorbate is mediated by the generation H2O2 via oxidation ascorbate. Because pancreatic cancer cells are sensitive to generated ascorbate, they would also be expected become sensitized agents that increase oxidative damage such as ionizing radiation. current study demonstrates enhances cytotoxic effects radiation seen decreased cell viability and clonogenic survival in all lines examined, but not nontumorigenic ductal epithelial cells. Ascorbate...
Non-small-cell lung cancer (NSCLC) represents approximately 80-85% of diagnoses and is the leading cause cancer-related death worldwide. Recent studies indicate that image-based radiomics features from positron emission tomography/computed tomography (PET/CT) images have predictive power for NSCLC outcomes. To this end, easily calculated functional such as maximum mean standard uptake value (SUV) total lesion glycolysis (TLG) are most commonly used prognostication, but their prognostic...
Importance Understanding environmental risk factors for gestational diabetes (GD) is crucial developing preventive strategies and improving pregnancy outcomes. Objective To examine the association of county-level radon exposure with GD in pregnant individuals. Design, Setting, Participants This multicenter, population-based cohort study used data from Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) cohort, which recruited nulliparous participants 8 US clinical...
Background and Purpose. High-quality measurements are needed to develop meaningful clinical practice databases assess the effectiveness of physical therapy. This study determined reliability, validity, responsiveness obtained with five functional tests graded newly developed Iowa Level Assistance Scale. Subjects Methods. Eighty-six patients total hip or knee replacements were tested at various time periods during their hospitalization. Patients for activities by four therapists establish...