In recent years, the terms machine learning, data science, and predictive modeling have become ubiquitous in nearly every discipline which analysis plays a central role. When first diving i...

The atypical antipsychotic risperidone (RSP) is often associated with weight gain and cardiometabolic side effects. mechanisms for these adverse events are poorly understood and, undoubtedly, multifactorial in etiology. In light of growing evidence implicating the gut microbiome host's energy regulation xenobiotic metabolism, we hypothesized that RSP treatment would be changes children adolescents. Thus, impact chronic (>12 months) short-term use on pediatric psychiatrically ill male...

Firearm injuries disproportionately affect young, male, non-White populations, causing substantial individual and societal burden. Annual costs for hospitalized firearm have not been widely described, as most previous cost studies focused on lifetime costs. We examined a nationally-representative database of hospitalizations in the US to estimate per-hospital overall hospital by intent, type weapon, payer source.We conducted retrospective cohort study all injury National Inpatient Sample...

Background In Alzheimer's disease (AD), tau and white matter lesion pathology are associated with clinical severity subsequent decline, but their relative relationships assessments remain uncertain. Objective To examine cross-sectional prognostic associations between baseline [ 18 F]GTP1 positron emission tomography (PET) standardized uptake value ratio (SUVRs) T1 hypointensity (WMHypo) volumes indices. Methods We analyzed participants biomarker-confirmed prodromal (n = 127) or mild 233) AD...

Abstract Depression has been associated with reduced bone mass in adults, but the mechanisms remain unclear. In addition, little is known about association between depression and health during growth development. To address this knowledge gap, we examined density structure 222 adolescents young adults (69% females, mean ± SD age: 19.0 1.5 years), enrolled within 1 month of starting a selective serotonin reuptake inhibitor (SSRI) or unmedicated. Psychiatric functioning was assessed...

Prior observational work in a heterogeneous cohort of participants with mild cognitive impairment suggests the Amsterdam Instrumental Activities Daily Living Questionnaire (A-IADL-Q) may have greater sensitivity for functional decline than more established Alzheimer's Disease Cooperative Study-Activities (ADCS-ADL) scale. However, relative utility A-IADL-Q versus ADCS-ADL clinical trials early disease (AD) remains uncertain.

Abstract Background Racial/ethnic disparity has been documented in a wide variety of health outcomes, and environmental components are contributors. For example, food deserts have tied to obesity rates. Pedestrian injuries strongly factors, yet no studies examined racial pedestrian injury We examine nationally-representative sample pedestrian-related hospitalizations the United States identify differences incidence, severity, cost by race/ethnicity. Methods Patients with ICD diagnosis...

Substantial evidence exists to indicate bidirectional relationships between obesity and depressive disorders the importance of fat distribution this relationship. This analysis used a well-characterized sample individuals in late adolescence determine association illness distribution.

Latent infection with toxoplasmosis is a prevalent condition that has been linked in animal studies to high-risk behaviors, and humans, suicide attempts. This analysis investigated relationship between attempt history titers group of older adolescents who had recently begun treatment an SSRI. Of 108 participants, 17 (15.7 %) lifetime at least one attempt. All were given structured unstructured diagnostic interviews provided blood samples. Two individuals (11.9%) past attempt, two (2.1%)...

Article AbstractObjective: To examine sexual functioning in adolescents with depression.Methods: Between September 2010 and March 2014, 235 participants who were between 15 20 years old unmedicated or within 1 month of beginning antidepressant treatment completed the Beck Depression Inventory (BDI), Anxiety (BAI), Changes Sexual Functioning Questionnaire (CSFQ). They also assessed to establish presence a DSM-IV-TR major depressive episode (MDE). The Student t test χ2 used compare continuous...

We conducted a secondary analysis of the National Inpatient Sample (NIS) to examine child abuse and neglect hospitalization from 1998-2016. The NIS is largest all-payer, inpatient care database in United States maintained by Health Care Utilization Project. Participants were youth 18 years younger with discharged diagnoses hospitals. rate or hospitalizations did not vary significantly over study period (1998-2016), which on average was 6.9 per 100,000 children annually. Males (53.0%),...

Cognitive and physical impairment can occur with dementia reduce driving ability. In the United States, individual states have procedures to refer evaluate drivers who may no longer be fit drive. The license review process is not well understood for dementia. This study uses comprehensive data from Iowa Department of Transportation compare referral without January 2014 through November 2019. likelihood failing an evaluation test was compared between using logistic regression. risk...

Abstract Objective To investigate national trends of SBS diagnosis codes and how varied among patient hospital characteristics. Methods We examined possible SBS, confirmed non-SBS abuse children age three younger who were hospitalized for between 1998 2014 using a secondary analysis the National Inpatient Sample, largest US all-payer inpatient care database ( N = 66,854). A baseline category logit model was used based on quasi-likelihood approach (QIC) with an independent working correlation...

Objectives: Teen drivers are at increased crash risk, largely due to lack of experience. Parents play a key role in influencing teen behaviors and attitudes around driving safety. Parent-involved interventions may improve safety but tend be resource intensive have limited scalability. In this study, we examined how family communication patterns (FCPs) impact risky the effectiveness parent-focused intervention. Methods: Our data came from large randomized controlled intervention trial. We...

Anatomical variations of the extensor pollicis longus (EPL) tendon are rare. Variations typically asymptomatic, yet knowledge these poses significance in setting dorsal approaches to wrist surgery. We present a case an accessory EPL that was discovered intraoperatively fourth compartment during open repair distal radius fracture with spanning plate. If not correctly identified, could have been entrapped beneath plate, resulting limited thumb extension and potentially rupture.

OBJECTIVE Substantial evidence exists to indicate bidirectional relationships between obesity and depressive disorders the importance of fat distribution this relationship. This analysis used a well-characterized sample individuals in late adolescence determine association illness distribution. METHOD Medically healthy 15- 20-year-olds, one-half whom had recently begun treatment with selective serotonin reuptake inhibitor, underwent comprehensive psychiatric evaluation that resulted...

Abstract Objective To investigate national trends of SBS diagnosis codes and how varied among patient hospital characteristics. Methods We examined possible SBS, confirmed total non-SBS abuse diagnoses children age three younger who were hospitalized for between 1998 2014 using a secondary analysis the National Inpatient Sample, largest US all-payer inpatient care database ( N = 66,854). A baseline category logit model was used based on quasi-likelihood approach (QIC) with an independent...

Abstract Objective To investigate national trends of SBS diagnosis codes and how varied among patient hospital characteristics. Methods We examined possible confirmed diagnoses children age three younger who were hospitalized for abuse between 1998 2014 using a secondary analysis the National Inpatient Sample, largest US all-payer inpatient care database ( N = 52,562). A baseline category logit model was used based on quasi-likelihood approach (QIC) with an independent working correlation...