A5069486509- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Esophageal Cancer Research and Treatment
- Vitamin C and Antioxidants Research
- Gastric Cancer Management and Outcomes
- Radiation Therapy and Dosimetry
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Advanced Radiotherapy Techniques
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Ubiquitin and proteasome pathways
- Genital Health and Disease
- Head and Neck Cancer Studies
University of California, San Francisco
2024-2025
University of San Francisco
2024
University of California, Irvine Medical Center
2021-2024
University of California, Irvine
2020-2024
University of California San Francisco Medical Center
2024
University of Iowa Hospitals and Clinics
2007-2023
UC Irvine Health
2023
University of Iowa
2017-2019
The University of Texas MD Anderson Cancer Center
2014-2016
University of Houston
2016
Non-small-cell lung cancer (NSCLC) represents approximately 80-85% of diagnoses and is the leading cause cancer-related death worldwide. Recent studies indicate that image-based radiomics features from positron emission tomography/computed tomography (PET/CT) images have predictive power for NSCLC outcomes. To this end, easily calculated functional such as maximum mean standard uptake value (SUV) total lesion glycolysis (TLG) are most commonly used prognostication, but their prognostic...
Effective treatment options for locally advanced esophageal cancer are limited, and rates of local recurrence after standard chemoradiotherapy remain high.To evaluate toxic effects, control, overall survival with a simultaneous integrated boost radiotherapy dose to the gross tumor nodal disease patients unresectable cancer.A phase 1/2, single-arm trial was conducted in 46 from April 28, 2010, 9, 2015 (median follow-up, 52 months [range, 2-86 months]), at tertiary academic center. Outcomes...
Standard treatment for glioblastoma (GBM) includes surgery, radiation therapy (RT), and temozolomide (TMZ), yielding a median overall survival (OS) of approximately 14 months. Preclinical models suggest that pharmacologic ascorbate (P-AscH-) enhances RT/TMZ antitumor effect in GBM. We evaluated the safety adding P-AscH- to standard therapy.This first-in-human trial was divided into an RT phase (concurrent RT/TMZ/P-AscH-) adjuvant (ADJ) (post RT/TMZ/P-AscH- phase). Eight dose cohorts were...
125 Background: Addition of NHT, including Abiraterone, Enzalutamide, Apalutamide, and Darolutamide, to androgen deprivation therapy in patients with advanced PCa demonstrated improved survival large randomized controlled trials. However, NHTs are associated development metabolic syndrome CV toxicity. Treatment related adverse events (TRAEs) may include hypertension (HTN), hyperglycemia, atrial fibrillation, myocardial infarction (MI), congestive heart failure (CHF), stroke. As such,...
734 Background: EV is an antibody drug conjugate that was approved in the United States as monotherapy for pretreated advanced UC and, then, combination with P untreated pts. However, associated multiple toxicities, which are mostly non-overlapping those of P. In EV-302 study, grade (G) 3 or higher treatment-related adverse events (TRAEs) occurred 55.9% pts and led to treatment discontinuation 35.0% on EV+P. Pts aged 80 years older (i.e. ultra elderly) a special population, who may be...
Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to targets by E1-E2-E3 multienzyme cascades. The Sumo cascade, conserved among all eukaryotes, regulates numerous biological processes including protein localization, transcription, DNA replication, mitosis. conjugation is initiated the heterodimeric Aos1-Uba2 E1 enzyme (in humans called Sae1-Uba2), which activates Sumo's C-terminus, binds dedicated E2 Ubc9, promotes C-terminal transfer between...
Aims: To analyze outcomes in primary anorectal melanoma, a rare disease with limited data and treatment guidelines. Materials & methods: We analyzed 305 subjects the National Cancer Database from 2004 to 2015. The end point was overall survival (OS). Results: Surgery predictive of OS (median 2.24 vs 1.18 years; p = 0.009) no difference between local transabdominal approaches (p 0.77). No benefit seen chemotherapy 0.16), radiotherapy 0.31) or adjuvant therapy post surgery > 0.05 for all...
Patients diagnosed with metastatic sarcoma have limited options for achieving both local and distant tumor control. While SBRT can achieve control, response rates remain low. There is evidence demonstrating the safety efficacy combining concurrent PD-1 checkpoint blockade in sarcoma. In this prospective case-series, we examined five patients on pembrolizumab treated concurrently from July 1, 2016-October 30, 2018. Acute chronic toxicity were recorded using Common Terminology Criteria Adverse...
Survival for pancreatic cancer remains poor. Surgical resection the only chance cure. The intent of this study was to investigate role socioeconomic status (SES) on rates adenocarcinoma. National Cancer Institute's Surveillance, Epidemiology, and End results database used identify patients with Disease deemed resectable or unresectable based extent disease code. Median family income as a SES variable compare who underwent those did not. organized into three categories definitions from...
Y-90 Selective Internal Radiotherapy (SIRT) is an ablative therapy used for inoperable liver metastasis. The purpose of this investigation was to examine the impact local control after SIRT on overall survival (OS) in oligometastatic patients. A retrospective, single-institution study identified patients with ≤5 non-intracranial metastases receiving unilateral or bilateral lobar from 2009 2021. primary endpoint OS defined completion date death last follow-up. Local failure classified as a...
Objectives Immunotherapy with immune checkpoint inhibitors has shown only limited success in the management of metastatic soft tissue sarcoma. Overall response rates (ORR) single agent pembrolizumab were 18% and median PFS was 18 weeks on clinical trial SARC028. One strategy to improve responses immunotherapy is stereotactic body radiation therapy (SBRT), which can enhance antitumor CD8 T cell through release tumor-specific antigens, potentially priming a more diverse class receptors....
The ability of tumors to evade detection by the immune system via inducing immunosuppression prompted therapeutic development checkpoint inhibitors. In our recent review, we discussed findings from preclinical and clinical investigations these agents utilized in combination with radiation abscopal (systemic) antitumor effects.
Aim: To explore management trends in preinvasive and cT1–T3 penile cancer. Materials & methods: The National Cancer Database was queried (2004–2013) for M0 cancer with specified nonpalliative surgical techniques histologies (n = 5,728). Results: Local excision (39%) partial penectomy (38%) were most commonly utilized. Patients cTis/Ta or cT1 disease more often received nonpenectomy approaches (p < 0.05); cT2–T3 cases likely underwent 0.001). No survival differences observed between (49.3...