A5087201995- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Health Systems, Economic Evaluations, Quality of Life
- Metastasis and carcinoma case studies
- Statistical Methods in Clinical Trials
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Advanced Radiotherapy Techniques
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Advances in Oncology and Radiotherapy
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Radiation Dose and Imaging
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
The University of Texas MD Anderson Cancer Center
2015-2024
University of Chicago Medical Center
2007-2022
Radiation Oncology Associates
2008-2022
Methodist Hospital
2019
European Neuroendocrine Tumor Society
2019
University of Nebraska Medical Center
2017
University of Florida
2017
UCLA Medical Center
2002-2017
University of Colorado Denver
2017
Roswell Park Comprehensive Cancer Center
2017
We performed a multi-institutional randomized trial comparing preoperative chemotherapy followed by surgery with alone for patients local and operable esophageal cancer.Preoperative randomly assigned to the group included three cycles of cisplatin fluorouracil. Surgery was two four weeks after completion third cycle; also received additional operation. Patients immediate-surgery underwent same surgical procedure. The main end point overall survival.Of 440 eligible adequate data , 213 were...
PURPOSE: To compare the local/regional control, survival, and toxicity of combined-modality therapy using high-dose (64.8 Gy) versus standard-dose (50.4 radiation for treatment patients with esophageal cancer. PATIENTS AND METHODS: A total 236 clinical stage T1 to T4, N0/1, M0 squamous cell carcinoma or adenocarcinoma selected a nonsurgical approach, after stratification by weight loss, primary tumor size, histology, were randomized receive consisting four monthly cycles fluorouracil (5-FU)...
PURPOSE: To compare the local/regional control, survival, and toxicity of combined-modality therapy using high-dose (64.8 Gy) versus standard-dose (50.4 radiation for treatment patients with esophageal cancer. PATIENTS AND METHODS: A total 236 clinical stage T1 to T4, N0/1, M0 squamous cell carcinoma or adenocarcinoma selected a nonsurgical approach, after stratification by weight loss, primary tumor size, histology, were randomized receive consisting four monthly cycles fluorouracil (5-FU)...
To update the 2000 American Society of Clinical Oncology guideline on colorectal cancer surveillance.Based results from three independently reported meta-analyses randomized controlled trials that compared low-intensity and high-intensity programs surveillance, recent analyses data major clinical in colon rectal cancer, Panel recommends annual computed tomography (CT) chest abdomen for 3 years after primary therapy patients who are at higher risk recurrence could be candidates...
We update Radiation Therapy Oncology Group trial 8911 (USA Intergroup 113), a comparison of chemotherapy plus surgery versus alone for patients with localized esophageal cancer. The relationship between resection type and tumor response outcome were also analyzed.The group received preoperative cisplatin fluorouracil. Outcome based on the (R0, R1, R2, or no resection) was evaluated. main end point overall survival. Disease-free survival, relapse pattern, influence postoperative treatment, to...
The purpose of this study was to develop accurate models and nomograms predict local recurrence, distant metastases, survival for patients with locally advanced rectal cancer treated long-course chemoradiotherapy (CRT) followed by surgery allow a selection who may benefit most from postoperative adjuvant chemotherapy close follow-up.All data (N = 2,795) five major European clinical trials were pooled used perform an extensive analysis multivariate based on Cox regression. Data one trial as...
The College of American Pathologists offers these protocols to assist pathologists in providing clinically useful and relevant information when reporting results surgical specimen examinations. regards the elements "Surgical Pathology Cancer Case Summary (Checklist)" portion as essential pathology report. However, manner which are reported is at discretion each specific pathologist, taking into account clinician preferences, institutional policies, individual practice.The developed an...
In Brief Objective: Our aims were to (1) determine the long-term oncologic outcome for patients with rectal cancer treated preoperative combined modality therapy (CMT) followed by total mesorectal excision (TME), (2) identify factors predictive of outcome, and (3) significance extent pathologic tumor response. Summary Background Data: Locally advanced (T3–4 and/or N1) adenocarcinoma is commonly CMT TME. However, results this approach a durable remain largely unknown. Methods: Two hundred...
Purpose The American Society of Clinical Oncology (ASCO) has a policy and set procedures for endorsing recent clinical practice guidelines that have been developed by other professional organizations. Methods Cancer Care Ontario (CCO) Guideline on Follow-up Care, Surveillance Protocol, Secondary Prevention Measures Survivors Colorectal was reviewed ASCO methodologic rigor considered endorsement. Results Panel concurred with the CCO recommendations recommended endorsement, addition several...
Seminal investigation 2 decades ago alerted the oncology community to age disparities in participation cooperative group trials; less is known about whether these persist industry-funded research.To characterize among trial enrollees on randomized clinical trials (RCTs) of common cancers and identify factors associated with wider imbalances.Phase 3 RCTs were identified through ClinicalTrials.gov.Multiarm assessing a therapeutic intervention for patients breast, prostate, colorectal, or lung...
PURPOSE: This study was designed to review experience with neuroendocrine carcinomas of the colon and rectum at a single institution, emphasis on pathology clinical characteristics this uncommon malignancy. METHODS: A group patients identified from prospective colorectal service database. Pathology reviewed tumors were classified by pathologist. Medical records retrospectively reviewed. RESULTS: From March 1975 September 1998, 38 database comprising 6495 (0.6 percent). These did not include...
To review the authors' experience with local excision of early rectal cancers to assess effectiveness initial treatment and salvage surgery.Local for cancer is appealing its low morbidity excellent functional results. However, use limited by inability regional lymph nodes uncertainty oncologic outcome.Patients T1 T2 adenocarcinomas rectum treated as definitive surgery between 1969 1996 at institution were reviewed. Pathology slides Among 125 assessable patients, 74 51 T2. Thirty-one patients...
Whole-body 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) imaging before and after induction therapy was prospectively evaluated in patients with esophageal cancer to determine whether changes PET images could measure response therapy.Between April 1997 1999, 39 (34 men five women; median age, 59 years; range, 36 76 years) were enrolled a single-institution clinical trial of staging, including PET, therapy, restaging esophagectomy. All undergoing esophagectomy (n = 17)...
Objective To determine perioperative morbidity, survival, and local failure rates in a large group of consecutive patients with rectal cancer undergoing low anterior resection by multiple surgeons on specialty service. The primary objective was to assess the surgical complications associated preoperative radiation sequencing. Summary Background Data goals treatment are cure, control, preservation sphincter, sexual, bladder function. Surgical using sharp perimesorectal dissection is important...
A 1990 National Institutes of Health Consensus Conference recommended that patients with stage III colon cancer receive adjuvant chemotherapy because survival was improved in clinical trials who received a 5-fluorouracil-based regimen.