A5089721939- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Colorectal and Anal Carcinomas
- Cancer survivorship and care
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
- Radiation Therapy and Dosimetry
- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Multiple and Secondary Primary Cancers
- Breast Cancer Treatment Studies
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Hepatocellular Carcinoma Treatment and Prognosis
St. John Medical Center
2021-2022
Summa Health System
2020
Michigan Cancer Research Consortium
2015-2019
Trinity Health Grand Rapids
2005-2018
Grand Rapids Community College
2014-2018
Michigan State University
2010-2018
Università Cattolica del Sacro Cuore
2015
University of Saint Mary
2012
Memorial Sloan Kettering Cancer Center
2002-2005
Cornell University
2002
Objectives To evaluate the feasibility of intensity-modulated radiotherapy with simultaneous integrated boost to dominant intraprostatic lesion for definitive treatment prostate cancer. Materials and Methods Patients were deemed eligible study if they had histologically proven stage cT2-T3 N0M0 adenocarcinoma. In addition <20% risk lymph nodal involvement according Roach formula, was required enrollment. treated technique defined by magnetic resonance imaging. The prescribed dose seminal...
Aim: To evaluate outcome of an accelerated radiotherapy (RT) regimen in elderly patients with early stage non-melanoma skin cancer (NMSC). Methods: Total RT dose was 30 Gy 5 fractions six consecutive days. Results: Thirty-one were enrolled. Fourteen aged ≥80 years. Acute and observed late toxicity exclusively grade 1. Thirty showed a complete response (median follow-up months). Two-year actuarial local control 93.2%. The cosmetic result mostly judged as good or excellent. Conclusions:...
Cancer-related fatigue (CRF) is a common side effect of adjuvant therapy and becomes chronic problem for approximately one-third survivors. Omega-3 polyunsaturated fatty acids (O3-PUFA) demonstrated preliminary antifatigue effects in previous research, but have not been investigated fatigued cancer survivors.Breast survivors 4-36 months posttreatment with CRF score 4 or more 10 using the symptom inventory (SI) were randomly assigned to O3-PUFA (fish oil, 6 g/d), omega-6 PUFA (O6-PUFA;...
Abstract Background Radiotherapy (RT) is widely used in the treatment of pancreatic cancer. Currently, recommendation has been given for delineation clinical target volume (CTV) adjuvant RT. Based on recently reviewed pathologic data, aim this study to propose criteria CTV definition and including elective nodal irradiation (ENI) preoperative definitive Methods The anatomical structures interest, as well abdominal vasculature were identified intravenous contrast-enhanced CT scans two...
Cancer-related fatigue is a prevalent and debilitating condition that persists for years into survivorship. Studies evaluating both fish oil supplementation on associations between consumption have shown mixed effects; it unknown what factors contribute to these differential effects. Herein, we investigate whether the nutritional status of cancer survivors was associated with serum omega-3 concentration or change in omega-3s throughout study, then if any were fatigue. Breast 4-36 months...
Background. An intensified multidrug chemotherapy regimen (raltitrexed plus oxaliplatin, Tom-Ox) concomitant boost radiotherapy, in the neoadjuvant treatment of locally advanced rectal cancer patients, was shown feasible our previous study. The aim this study to evaluate efficacy terms pathologic complete response pre-operative therapy. Material and methods: A Phase II designed clinical stage T3-T4 and/ or N ≥ 1 patients were treated with radiotherapy (55 Gy/5 weeks) concurrent (Tom-Ox)....
Hot flashes are a common symptom in breast cancer survivors that can negatively impact quality of life. Preliminary data suggested magnesium might be used as an effective low-cost treatment hot with minimal adverse effects.A four-arm, double-blind, placebo-controlled, randomized trial was conducted. Postmenopausal women history and bothersome were into groups oxide 800 or 1,200 mg daily corresponding placebo at 2:2:(1:1) ratio. flash frequency score (number × mean severity) measured using...
To determine the maximal and safely dose of preoperative radiotherapy concurrently intensified chemotherapy regimen (raltitrexed plus oxaliplatin) in locally advanced rectal cancer patients.Patients with cT3-T4 and/or cN≥1 or recurrent were sequentially assigned to 4 treatment schedules chemoradiation: standard (50.4 Gy/5.5 wk) raltitrexed (cohort A), accelerated (55 Gy/5 B), oxaliplatin C), D). Patients treated cohorts 6 12 per group. The tolerated was exceeded if more than one-third...
The aim of this phase II study was to evaluate response and toxicity a prolonged chemoradiation regimen in patients with locally advanced cervical cancer.Three cycles concomitant chemotherapy were used cisplatin (20 mg/m², 2-hour intravenous infusion, days 1-4) 5-fluorouracil (1000 24-hour continuous administered at weeks 1, 5, 9 radiotherapy. In combination, radiotherapy delivered planning target volume (PTV) defined as the CTV (clinical volume) plus 8 mm. follows: gross tumor volume, upper...
To assess the effectiveness of a SHort-course Accelerated RadiatiON therapy (SHARON) in treatment patients with multiple brain metastases.A phase II clinical trial was designed. Eligibility criteria included at least 3 metastases or metastatic disease >3 organ systems, and Eastern Cooperative Oncology Group performance status ≤3. Fifty were treated whole radiotherapy 18 Gy (4.5 per fraction) 2 days twice daily fractionation. The primary endpoint assessment efficacy terms overall...
The incidence of noncancer pain (NCP) in cancer patients is unknown. An analysis incidence, severity, impact on quality life (QoL), and appropriateness NCP treatment a cohort referred to radiotherapy center reported.Pain was scored from 0 (absence) 3 (severe) the adequacy analgesic therapy evaluated according International Guidelines. Correlation between Pain Management Index World Health Organization Analgesic Ladder used analyze treatment. In addition, differentiated its origin types...
NRG Oncology RTOG 9704 was the first adjuvant trial to validate prognostic value of postresection CA19-9 levels for survival in patients with pancreatic carcinoma. The data resulting from this study also provide information about predictors recurrence that may be used tailor individualized management disease setting. This secondary analysis assessed and surgical margin status (SMS) predicting patterns recurrence.This multicenter cooperative included participants who were enrolled as at...
Aims: Low-dose radiation therapy (LDRT) can increase biological efficacy of chemotherapy. This Phase II trial evaluates LDRT plus FOLFIRI-bevacizumab (FOLFIRI-B) in metastatic colorectal cancer. Materials & methods: Primary objective: raising the clinical complete response rate from 5 to 25%. Secondary objectives: toxicity, progression-free survival. Patients underwent 12 FOLFIRI-B cycles two daily fractions (20 cGy/6 h interval) on each cycle. Statistical analysis was planned 18 patients....
Aims To investigate the technical feasibility of utilizing Active Breathing Coordinator for planning postoperative three-dimensional conformal radiation therapy in patients with early stage breast cancer undergoing conservation therapy. Methods Patients whom adjuvant radiotherapy after breast-conserving surgery was planned were consecutively enrolled. Five sessions simulation each patient. Computed tomography not acquired until a good level compliance procedure achieved by who did show...
The purpose of this study was to determine the expected time prostate specific antigen (PSA) normalization with or without neoadjuvant androgen deprivation (NAAD) therapy after treatment intensity modulated radiotherapy (IMRT) for patients clinically localized cancer.A retrospective cohort research design used. A total 133 clinical stage T1c T3b cancer (2002 AJCC staging) treated in a community setting between January 2002 and July 2005 were reviewed PSA using 1 ng/mL 2 as criteria. All...