A5090143035- Neutropenia and Cancer Infections
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- Frailty in Older Adults
- Cancer-related cognitive impairment studies
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
- Venous Thromboembolism Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Blood disorders and treatments
- Chemotherapy-related skin toxicity
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Hematological disorders and diagnostics
- Glioma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Lymphoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Central Venous Catheters and Hemodialysis
- Patient-Provider Communication in Healthcare
- Chemotherapy-induced cardiotoxicity and mitigation
- Fungal Infections and Studies
University of Rochester Medical Center
2007-2025
University of Rochester
2010-2025
National Cancer Institute
2019-2022
Fred Hutch Cancer Center
2014-2018
Duke Medical Center
2004-2017
University of Washington
2006-2017
Duke University
2006-2017
Duke Cancer Institute
2017
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2015
Seattle University
2010
Abstract BACKGROUND The incidence of venous thromboembolism (VTE) is increased in cancer, but little information available about risk factors cancer patients on chemotherapy. METHODS We analyzed data from a prospective, multicenter observational study to determine the frequency and for VTE ambulatory initiating new chemotherapy regimen. association with clinical variables was characterized using univariate multivariate analysis. RESULTS Among 3003 treated at least one cycle chemotherapy,...
Cancer is associated with thrombosis, but the frequency of thromboembolism in hospitalized cancer patients receiving current chemotherapy regimens not known. We investigated venous and arterial outcomes actively therapy, as identified by neutropenia.We conducted a retrospective cohort study using discharge database University HealthSystem Consortium. This included 66,106 adult neutropenic 88,074 hospitalizations between 1995 2002 at 115 medical centers United States.Thromboembolism was...
Anemia is frequent in patients with cancer, but there are concerns regarding treatment erythropoiesis-stimulating agents. Blood transfusions commonly used as an alternative, little data outcomes.In a retrospective cohort study, we investigated the associations between and venous thromboembolism, arterial mortality hospitalized cancer using discharge database of University HealthSystem Consortium, which included 504 208 hospitalizations 1995 2003 at 60 US medical centers.Of included, 70 542...
Older patients with cancer and their caregivers worry about the effects of treatment on aging-related domains (eg, function cognition). Quality conversations oncologists concerns could improve patient-centered outcomes. A geriatric assessment (GA) can capture evidence-based conditions associated poor clinical outcomes toxic effects) for older cancer.To determine whether providing a GA summary GA-guided recommendations to communication concerns.This cluster-randomized trial enrolled 541...
This perspectives paper provides an overview of how to read and interpret a Sankey, examples using symptom data from older adults with advanced cancer, synopsis medical literature, comments on creating the diagram for presentation data. From prior reports our own, we conclude Sankeys are excellent tool visualizing changing status patients cancer. Older adult is used as example dispalyed in range Sankey flow diagrams. Because there large heterogeneity aging, different subgroups can be...
Abstract BACKGROUND: A prospective cohort study was undertaken to develop and validate a risk model for neutropenic complications in cancer patients receiving chemotherapy. METHODS: The population consisted of 3760 with common solid tumors or malignant lymphoma who were beginning new chemotherapy regimen at 115 practice sites throughout the United States. regression developed then validated by using random split‐sample selection process. RESULTS: No significant differences derivation...
This study was undertaken to describe the relationship between occurrence and timing of neutropenic events chemotherapy treatment in a community-based population patients with cancer. The included 2962 breast, lung, colorectal, lymphoma, ovarian cancers from prospective U.S. registry initiating new regimen. Detailed patient-, disease-, treatment-related data, including toxicities, were captured at baseline, beginning each cycle, midcycle blood draw for up 4 cycles treatment. Primary outcomes...
Abstract Neutropenic complications remain an important dose‐limiting toxicity of cancer chemotherapy‐associated with considerable morbidity, mortality, and cost. Risk the initial neutropenic event is greatest during first cycle. The purpose this study was to better understand timing events in relation delivered chemotherapy dose intensity utilization supportive care treatment. A prospective cohort adult patients solid tumors or lymphoma initiating conducted at 115 randomly selected US...
<h3>Importance</h3> Financial toxicity (FT), unintended and unanticipated financial burden experienced by cancer patients undergoing care, is associated with negative consequences increased risk of mortality. Older (≥70 years) are at for FT, yet data limited on FT whether oncologists discuss their patients. <h3>Objective</h3> To examine the prevalence in older adults advanced cancer, its association health-related quality life (HRQoL), cost conversations between <h3>Design, Setting,...
12009 Background: GA evaluates aging-related domains (e.g., function) known to be associated with cancer treatment toxicity. In this CRCT, we evaluated if providing a summary management recommendations oncologists can reduce toxicity in older patients (pts) advanced receiving chemotherapy and/or other agents high reported prevalence of grade 3-5 Methods: Pts aged > 70 incurable solid tumors or lymphoma and 1 impaired domain starting new regimen were enrolled. Community oncology practices...
To evaluate the relationships between aging-related domains captured by geriatric assessment (GA) for older patients with advanced cancer and caregivers' emotional health quality of life (QOL).In this cross sectional study baseline data from a nationwide investigation their caregivers, completed GA that included validated tests to eight (eg, function, cognition).Thirty-one community oncology practices throughout United States.Enrolled were aged 70 older, had one or more domain impaired, an...
Abstract Background Polypharmacy is common in older adults who are starting cancer treatment and associated with an increased risk of potentially inappropriate medications (PIMs) potential drug‐drug interactions (PDIs). The authors evaluated the association medication measures adverse outcomes advanced were receiving systemic therapy. Methods This secondary analysis from GAP 70+ Trial (ClinicalTrials.gov identifier NCT02054741; principal investigator, Supriya G. Mohile) enrolled patients...
Purpose Breast cancer outcomes are worse among black women and of lower socioeconomic status. The purpose this study was to investigate racial social differences in selection breast adjuvant chemotherapy regimens. Methods Detailed information on patient, disease, treatment factors collected prospectively 957 patients who were receiving 101 oncology practices throughout the United States. Adjuvant regimens included any several published guidelines considered standard. Receipt nonstandard...
This prospective study was undertaken to evaluate patient and treatment characteristics that contribute hematologic toxicity in older cancer patients.A nationwide of 115 community oncology practices conducted between 2002 2005 with data collected on 976 patients who had received chemotherapy for common malignancies, including lung cancer, colorectal breast ovarian genitourinary lymphoma. Primary outcomes included severe neutropenia (SN) febrile (FN). Secondary delivered relative dose...
The purpose of this study was to investigate the relationship between socioeconomic status (SES) and use intentionally reduced doses chemotherapy in adjuvant treatment breast cancer.Patients with cancer treated a standard regimen (n = 764) were enrolled prospective registry after signing informed consent. Detailed information collected on patient, disease, treatment, including doses. Zip code level data median household income, proportion people living below poverty level, educational...