A5069595929- Frailty in Older Adults
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
- Cancer-related cognitive impairment studies
- Childhood Cancer Survivors' Quality of Life
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Inflammatory Biomarkers in Disease Prognosis
- Patient-Provider Communication in Healthcare
- Family Support in Illness
- Proteoglycans and glycosaminoglycans research
- Glioma Diagnosis and Treatment
- Tracheal and airway disorders
- Health and Wellbeing Research
- Immune cells in cancer
- Brain Metastases and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Intensive Care Unit Cognitive Disorders
- Occupational and environmental lung diseases
- Esophageal and GI Pathology
- Tryptophan and brain disorders
- Marine Sponges and Natural Products
- Congenital heart defects research
- Glycosylation and Glycoproteins Research
University of Rochester Medical Center
2017-2024
University of Rochester
2018-2024
National Cancer Institute
2019-2021
Older patients with cancer and their caregivers worry about the effects of treatment on aging-related domains (eg, function cognition). Quality conversations oncologists concerns could improve patient-centered outcomes. A geriatric assessment (GA) can capture evidence-based conditions associated poor clinical outcomes toxic effects) for older cancer.To determine whether providing a GA summary GA-guided recommendations to communication concerns.This cluster-randomized trial enrolled 541...
12009 Background: GA evaluates aging-related domains (e.g., function) known to be associated with cancer treatment toxicity. In this CRCT, we evaluated if providing a summary management recommendations oncologists can reduce toxicity in older patients (pts) advanced receiving chemotherapy and/or other agents high reported prevalence of grade 3-5 Methods: Pts aged > 70 incurable solid tumors or lymphoma and 1 impaired domain starting new regimen were enrolled. Community oncology practices...
To evaluate the relationships between aging-related domains captured by geriatric assessment (GA) for older patients with advanced cancer and caregivers' emotional health quality of life (QOL).In this cross sectional study baseline data from a nationwide investigation their caregivers, completed GA that included validated tests to eight (eg, function, cognition).Thirty-one community oncology practices throughout United States.Enrolled were aged 70 older, had one or more domain impaired, an...
Background: This study's objectives were to describe community oncologists' beliefs about and confidence with geriatric care determine whether geriatric-relevant information influences cancer treatment decisions. Methods: Community oncologists recruited participate in 2 multisite oncology trials. Participants shared their caring for older adults. They also asked make a first-line chemotherapy recommendation (combination vs single-agent no chemotherapy) hypothetical vignette of an patient...
Abstract Background Ensuring older patients with advanced cancer and their oncologists have similar beliefs about curability is important. We investigated discordance in patient-oncologist caregiver-oncologist dyads. Materials Methods used baseline data from a cluster randomized trial assessing whether geriatric assessment improves communication quality of life caregivers. Patients were aged ≥70 years incurable community oncology practices. Patients, caregivers, asked: “What do you believe...
OBJECTIVES To evaluate the independent association between symptom burden and physical function impairment in older adults with cancer. DESIGN Cross‐sectional. SETTING Two university‐based geriatric oncology clinics. PARTICIPANTS Patients cancer aged 65 years or who underwent evaluation assessment (GA). MEASUREMENTS Symptom was measured as a summary score of severity ratings (range = 0‐10) 10 commonly reported symptoms using Clinical Inventory (CSI). Functional defined presence one more...
Background: Cancer-related fatigue (CRF) negatively affects survivors’ walking, engagement in physical activity (PA), and quality of life (QoL). Yoga is an effective therapy for treating CRF; however, evidence from large clinical trials regarding how reducing CRF through yoga influences CRF’s interference with PA, QoL not available. We examined the effects mediational influence on among cancer survivors a multicenter phase III randomized controlled trial. Patients Methods: Cancer (n=410)...
OBJECTIVES To evaluate relationships between frailty and cognition longitudinally in adults 50 years older with breast cancer receiving chemotherapy. DESIGN Secondary analysis of a prospective longitudinal observational study. SETTING University Rochester NCI Community Oncology Research Program community oncology clinics. PARTICIPANTS Patients age adjuvant/neoadjuvant chemotherapy (n = 376) age‐matched controls without 234). MEASUREMENTS Frailty was assessed using modified score from...
Background Older patients with advanced cancer who are 100% certain they will be cured pose unique challenges for clinical decision making, but to the authors’ knowledge, prevalence and correlates of absolute certainty about curability (ACC) unknown. Methods Cross‐sectional data were collected in a geriatric assessment trial. ACC was assessed by asking patients, “What do you believe chances that your go away never come back treatment?” Response options (coded as ACC), >50%, 50/50,...
Background Despite recent advances in cancer, racial disparities treatment outcomes persist, and their mechanisms are still not fully understood. The objective of this study was to examine differences frailty geriatric assessment impairments an unselected cohort older adults with newly diagnosed gastrointestinal (GI) malignancies. Methods This used data from the Cancer Aging Resilience Evaluation Registry, a prospective that enrolled (≥60 years) GI malignancies who were presenting for...
Background Cancer-related fatigue (CRF) is a common side effect impacting breast cancer survivors. Research points to relationship between obesity and CRF in survivors related elevated systemic inflammation metabolic alterations.Methods This cross-sectional study examined the of CRF, inflammatory markers serum lipids through secondary analysis nationwide randomized controlled trial. Breast with were categorized based on BMI category. Symptoms fatty acids assessed among groups.Results There...
Background: Polypharmacy and potentially inappropriate medications (PIMs) are prevalent in older adults with cancer, but their associations physical function not often studied. This study examined the of polypharmacy PIMs determined optimal cutoff value for number most strongly associated functional impairment. Methods: cross-sectional analysis used baseline data from a randomized enrolling patients aged ≥70 years advanced cancer starting new systemic treatment. We categorized PIM using 2015...
Frailty is associated with an increased risk of chemotherapy toxicity. Cellular markers inflammation can help identify patients frailty characteristics. However, the role cellular in identifying at developing chemotherapy-induced and their clinical utility are not fully understood.This study was a secondary analysis large nationwide cohort women stage I-IIIC breast cancer (n = 581, mean age 53.4; range 22-81). Measures were completed pre-chemotherapy (T1), post-chemotherapy (T2), 6 months...
Abstract Background Aging-related deficits that eventually manifest as frailty may be associated with poor emotional health in older patients advanced cancer. This study aimed to examine the relationship between and this population. Methods was a secondary analysis of baseline data from nationwide cluster randomized trial. Patients were aged ≥70 years incurable stage III/IV solid tumors or lymphomas, had ≥1 geriatric assessment (GA) domain impairment, completed Geriatric Depression Scale,...
Abstract Background Inflammation may contribute to cognitive difficulties in patients with breast cancer. We tested 2 hypotheses: inflammation is elevated cancer vs noncancer control participants and associated worse attention processing speed over the course of chemotherapy. Methods Serum cytokines (interleukin [IL]–4, 6, 8, 10; tumor necrosis factor [TNF]–α) soluble receptors [sTNFRI, II]) were measured 519 females before after chemotherapy 338 without serving as participants. Attention by...
Abstract Background Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological may be used as a biomarker of biological predict individuals at risk. In addition, cancer treatment can also lead accelerated age. Exercise is promising intervention reduce prevent functional, psychological, cognitive impairments in older patients malignancies, yet there little evidence effects...
Cancer remains a formidable global health challenge, with metastasis being key contributor to its lethality. Abundant high molecular mass hyaluronic acid, major non-protein component of extracellular matrix, protects naked mole rats from cancer and reduces incidence in mice. Hyaluronidase plays critical role degrading acid is frequently overexpressed metastatic cancer. Here we investigated the potential targeting hyaluronidases reduce metastasis. A throughput screen identified delphinidin,...