A5078837203- Air Quality and Health Impacts
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Birth, Development, and Health
- Fatty Acid Research and Health
- Carcinogens and Genotoxicity Assessment
- Climate Change and Health Impacts
- Electromagnetic Fields and Biological Effects
- Noise Effects and Management
- Cancer-related cognitive impairment studies
- Selenium in Biological Systems
- Obsessive-Compulsive Spectrum Disorders
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Autism Spectrum Disorder Research
- Prenatal Substance Exposure Effects
- Trace Elements in Health
- Vitamin D Research Studies
- Child and Adolescent Psychosocial and Emotional Development
- Smoking Behavior and Cessation
- Heavy metals in environment
- Marine animal studies overview
- Nutrition and Health in Aging
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
University of Rochester
2016-2025
University of Rochester Medical Center
2015-2025
Eastman Chemical Company (United States)
2013-2019
University of Ulster
2012-2019
Eastman Dental Hospital
2015-2017
Food for Health Ireland
2015
Ministry of Health
2012-2015
Pediatrics and Genetics
2015
Government of the Republic of Korea
2012
International Psychogeriatric Association
2012
Phthalates impair rodent testicular function and have been associated with anti-androgenic effects in humans, including decreased testosterone levels. Low adult human males has increased prevalence of obesity, insulin resistance, diabetes.Our objective this study was to investigate phthalate exposure its associations abdominal obesity resistance.Subjects were U.S. male participants the National Health Nutrition Examination Survey (NHANES) 1999-2002. We modeled six metabolites prevalent known...
Clostridium difficile infection (CDI) is a major cause of hospital-acquired diarrhea and most commonly associated with changes in normal intestinal flora caused by administration antibiotics. Few studies have examined the risk CDI total dose, duration, or number antibiotics while taking into account complex exposures over time.A retrospective cohort study conducted from 1 January to 31 December 2005 among hospitalized patients 18 years older receiving 2 more days antibiotics.The identified...
Abstract Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to remission. These cases may be used identify therapeutic targets neuromodulation. We analyzed two cohorts of patients addicted smoking at the time focal (cohort 1 n = 67; cohort 2 62). Lesion locations were mapped atlas and network functionally connected each lesion location was computed using human connectome data ( 1,000). Associations with...
Rationale: Fine particulate matter air pollution of 2.5 μm or less in diameter (PM2.5) has been associated with an increased risk respiratory disease, but assessments specific infections adults are lacking.Objectives: To estimate the rate infection healthcare encounters acute increases PM2.5 concentrations.Methods: Using case–crossover methods, we studied 498,118 adult New York State residents a primary diagnosis influenza, bacterial pneumonia, culture-negative pneumonia upon hospitalization...
To determine whether concussed students experience greater academic dysfunction than who sustain other injuries.We conducted a prospective cohort study from September 2013 through January 2015 involving high school and college visited 3 emergency departments in the Rochester, New York, area. Using telephone surveys, we compared self-reported between 70 with concussions comparison group of 108 extremity injuries at 1 week month after injury.At injury, scores were approximately 16 points...
The response of respiratory infections to source-specific particulate matter (PM) is an area active research. Using PM2.5 concentrations at six urban sites in New York State, a case-crossover design, and conditional logistic regression, we examined the association between PM rate hospitalizations emergency department (ED) visits for influenza or culture-negative pneumonia from 2005 2016. There were most N = 14 764 hospitalizations, 57 522 ED visits, 274 226 113 997 included our analyses. We...
Previous studies reported triggering of acute cardiovascular events by short-term increasedPM2.5 concentrations. From 2007 to 2013, national and New York state air quality policies economic influences resulted in reduced concentrations PM2.5 other pollutants across the state. We estimated rate hospital admissions associated with increased previous 1-7 days, evaluated whether they differed before (2005-2007), during (2008-2013), after these concentration changes (2014-2016).Using Statewide...
The midbrain is biomechanically susceptible to force loading from repetitive subconcussive head impacts (RSHI), a site of tauopathy in chronic traumatic encephalopathy (CTE), and regulates functions (e.g., eye movements) often disrupted concussion. In prospective longitudinal design, we demonstrate there are reductions white matter integrity due single season collegiate football, that the amount reduction related rotational acceleration which players' brains exposed. We then replicate...
Previous work reported increased rates of acute cardiovascular hospitalizations associated with PM2.5 concentrations in the previous few days across urban centers New York State from 2005 to 2016. These relative were higher after air quality policies and economic changes resulted decreased PM composition (e.g. secondary organic carbon), compared before during these changes. Changes sources may explain this difference.To estimate rate increases source specific concentrations.Using apportioned...
Prior studies reported that exposure to increased concentrations of fine particulate matter (PM2.5) were associated with rates hospitalization and emergency department (ED) visits for asthma chronic obstructive pulmonary disease (COPD). In this study, examined from 2005 2016 using a case-crossover design ascertain if there have been changes in the per unit mass given substantial reductions PM2.5 concentration its composition. reduced through combination policies designed improve air quality...
Less is known regarding how these observed differences in sleep structure translate to notable problems and/or clinically relevant disorders children with DS.7][18][19][20] There a relative paucity of research addressing other problematic behaviors this population, Study Objectives: Down syndrome (DS) neurodevelopmental disorder characterized by multiple comorbidities.Sleep are common among DS and can cause signifi cant distress for families.However, limited describing correlates large...
Current pharmacotherapies for tobacco dependence are generally well tolerated, but have relatively high rates of relapse. They target primarily the brains' mesocorticolimbic 'reward' pathway. However, recent evidence suggests that insular cortex, a central cerebral hemispheric region historically overlooked in addiction models, may also play an important role cognitive and emotional processes facilitate drug use. We examined whether versus non-insular damage from ischemic stroke attenuated...
BackgroundThe etiology of childhood brain cancer remains largely unknown. However, previous studies have yielded suggestive associations with parental pesticide use.ObjectivesWe aimed to evaluate exposure pesticides at home and on the job in relation occurrence children.MethodsWe included 526 one-to-one–matched case–control pairs. Brain cases were diagnosed < 10 years age, identified from statewide registries four U.S. Atlantic Coast states. We selected controls by random digit dialing....
OBJECTIVES. The goal of the study was to test hypothesis that infants with known congenital diaphragmatic hernias born at early term gestation (37–38 weeks) rather than later (39–41 had greater survival rates and less extracorporeal membrane oxygenation use. Primary outcomes were hospital discharge or transfer METHODS. A retrospective cohort prenatal diagnoses hernia performed Congenital Diaphragmatic Hernia Study Group Registry patients who treated between January 1995 December 2006....
Though toxicological experiments demonstrate the teratogenicity of organic solvents in animal models, epidemiologic studies have reported inconsistent results. Using data from population-based National Birth Defects Prevention Study, authors examined relation between maternal occupational exposure to aromatic solvents, chlorinated and Stoddard solvent during early pregnancy neural tube defects (NTDs) orofacial clefts (OFCs).Cases NTDs (anencephaly, spina bifida encephalocoele) OFCs (cleft...
Prior work found increased rates for emergency department (ED) visits asthma and hospitalizations chronic obstructive pulmonary disease per unit mass of PM2.5 across New York State (NYS) during 2014-2016 after significant reductions in ambient concentrations had occurred following implementation various policy actions major economic disruptions. The associations source-specific with these respiratory diseases were assessed a time-stratified case-cossover design logistic regression models to...
Methylmercury (MeHg) is present in fish and a neurotoxicant at sufficiently high levels. One potential mechanism of MeHg toxicity early life epigenetic dysregulation that may affect long-term neurodevelopment. Altered DNA methylation nervous system-related genes has been associated with adult mental health outcomes. To assess associations between prenatal exposure (at the cytosine CG dinucleotides, CpGs) three genes, encoding brain-derived neurotropic factor (BDNF), glutamate receptor...