A5073372819- Smoking Behavior and Cessation
- Nicotinic Acetylcholine Receptors Study
- Heart Rate Variability and Autonomic Control
- Fatty Acid Research and Health
- Neurotransmitter Receptor Influence on Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Bacterial Identification and Susceptibility Testing
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and disorders
- Diphtheria, Corynebacterium, and Tetanus
- Diet and metabolism studies
- Telomeres, Telomerase, and Senescence
- Nosocomial Infections in ICU
- Hearing, Cochlea, Tinnitus, Genetics
- Nigella sativa pharmacological applications
- Cholesterol and Lipid Metabolism
- S100 Proteins and Annexins
- Natural Products and Biological Research
- Telemedicine and Telehealth Implementation
- Pharmacological Effects of Medicinal Plants
- Cerebrovascular and Carotid Artery Diseases
Philips (United States)
2015-2023
University of Rochester Medical Center
2013-2019
University of Rochester
2011-2017
IPS Research (United States)
2015
University of Virginia
2010
Abstract Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to remission. These cases may be used identify therapeutic targets neuromodulation. We analyzed two cohorts of patients addicted smoking at the time focal (cohort 1 n = 67; cohort 2 62). Lesion locations were mapped atlas and network functionally connected each lesion location was computed using human connectome data ( 1,000). Associations with...
Remote assessments of individuals with a neurological disease via telemedicine have the potential to reduce some burdens associated clinical care and research participation. We aim evaluate feasibility conducting Montreal Cognitive Assessment remotely in movement disorders. A pilot study derived from two trials was conducted. In total, 17 disorders (8 Parkinson 9 Huntington disease) had examinations evaluated in-person web-based video conferencing primarily determine barriers its remote...
Abstract A recent clinical study demonstrated that damage to the insular cortex can disrupt tobacco addiction. The neurobiological mechanisms for this effect are not yet understood. In we used an animal model of nicotine addiction examine possibility changes in levels dopamine (DA)‐ and cAMP‐regulated phosphoprotein 32 kDa (DARPP‐32), a enriched DA neurons containing D1 receptors, may be associated with vulnerability Once rats acquired self‐administration, they were given unlimited access...
Current pharmacotherapies for tobacco dependence are generally well tolerated, but have relatively high rates of relapse. They target primarily the brains' mesocorticolimbic 'reward' pathway. However, recent evidence suggests that insular cortex, a central cerebral hemispheric region historically overlooked in addiction models, may also play an important role cognitive and emotional processes facilitate drug use. We examined whether versus non-insular damage from ischemic stroke attenuated...
<h3>Background</h3> The risk factors for sporadic (ie, non-familial) retinoblastoma remain largely unknown. <h3>Objectives</h3> We examined the relationship between paternal occupational exposures from jobs held 10 years and 1 year prior to conception of bilateral in children. <h3>Methods</h3> Paternal data were obtained 198 incident cases diagnosed with January 1998 May 2006 245 referral-based controls case child9s relatives friends who matched 135 on birth year. Industrial hygienists...
Smoking urges are fundamental aspects of nicotine dependence that contribute significantly to drug use and postquit relapse. Recent evidence has indicated damage the insular cortex disrupts smoking behaviors claims reduce associated with use, although tools assess urge have yet be used validate these findings. We examined effect versus non-insular on using a well-accepted scale.This 3-month observational prospective cohort study consisted 156 current smokers hospitalized for acute ischemic...
There is a lack of research on the use electronic tools that guide patients toward reducing their cardiovascular disease risk. We conducted 9-month clinical trial in which participants who were at low (n = 100) and moderate 23) risk-based National Cholesterol Education Program III's 10-year risk estimator-were randomized to usual care or plus an Interactive Advisory Tool during first 8 weeks study. In moderate-risk category, interaction between treatment condition Framingham estimate...
Abstract Background Whole-genome sequencing (WGS) of bacteria is becoming a routine tool within microbiology, yet its utility to help guide infection control (IC) practice longitudinally underexplored. As with any technology adopted in the hospital, integration WGS into IC must be carefully managed and considered. We qualitatively report an evidence-based implementation workflow that considers proactively professionals during investigation infectious outbreaks. Methods built upon lessons...
Background: Lysophosphatidic acids (LPA) and lysophosphatidylcholines (LPC) are phospholipids, each containing one fatty acid, have effects on atherogenic mechanisms. No data currently exist regarding the of aspirin fish oil (FO) ingestion these potent lipid mediators in humans with diabetes mellitus (DM). We hypothesized that agents alter LPA LPC concentrations correlate platelet function. Methods: Using a sequential clinical trial approach, 30 adults type 2 DM were treated 81 mg/d for 7...