A5077179906- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Pain Management and Treatment
- Neuroscience and Music Perception
- Vestibular and auditory disorders
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Neurobiology of Language and Bilingualism
- Fetal and Pediatric Neurological Disorders
- Sleep and Wakefulness Research
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Neural Engineering
- Attention Deficit Hyperactivity Disorder
- Psychosomatic Disorders and Their Treatments
- Bipolar Disorder and Treatment
- Cerebrospinal fluid and hydrocephalus
- Ultrasound and Hyperthermia Applications
University of Iowa
2011-2025
University of Iowa Hospitals and Clinics
2017-2024
Carver Bible College
2020-2024
Hudson Institute
2019-2023
John Wiley & Sons (United States)
2019-2023
Liechtenstein Institute
2023
Cognitive Neuroimaging Lab
2023
Stanford University
2021-2022
Inspire Institute
2022
Harvard University
2011-2021
A traditional and widely used approach for linking neurological symptoms to specific brain regions involves identifying overlap in lesion location across patients with similar symptoms, termed mapping. This is powerful broadly applicable, but has limitations when do not localize a single region or stem from dysfunction connected the site rather than itself. newer sensitive such network effects functional neuroimaging of patients, this requires specialized scans beyond routine clinical data,...
To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network.We compared 12 lesions 24 control using voxel-based lesion-symptom mapping in case-control design identify site significantly associated with coma. We next used resting-state from healthy cohort network of regions functionally connected this site. further investigated the cortical by comparing their spatial topography that known networks evaluating patients disorders consciousness.A...
Abstract Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to remission. These cases may be used identify therapeutic targets neuromodulation. We analyzed two cohorts of patients addicted smoking at the time focal (cohort 1 n = 67; cohort 2 62). Lesion locations were mapped atlas and network functionally connected each lesion location was computed using human connectome data ( 1,000). Associations with...
Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral atrophy, improves behavioral testing performance in mouse models of AD. Here, we report data from (1) a Phase 1 feasibility study (NCT04042922, ClinicalTrials.gov) cognitively normal volunteers (n = 25), patients with mild AD dementia 16), epilepsy who underwent intracranial electrode monitoring 2) to assess safety single brief...
Abstract Clinicians and scientists alike have long sought to predict the course severity of chronic post-stroke cognitive motor outcomes, as ability do so would inform treatment rehabilitation strategies. However, it remains difficult make accurate predictions about outcomes due, in large part, high inter-individual variability recovery a reliance on clinical heuristics rather than empirical methods. The neuroanatomical location stroke is key variable associated with long-term because lesion...
Abstract Stroke significantly impacts the quality of life. However, long-term cognitive evolution in stroke is poorly predictable at individual level. There an urgent need to better predict symptoms based on acute clinical neuroimaging data. Previous works have demonstrated a strong relationship between location white matter disconnections and symptoms. rendering entire space possible disconnection-deficit associations optimally surveyable will allow for systematic association brain...
Emerging data on the neural mechanisms of impulse control highlight brain regions involved in emotion and decision making, including ventromedial prefrontal cortex (vmPFC), anterior cingulate (ACC) amygdala. Variation development these may influence one's propensity for impulsivity and, by extension, vulnerability to disorders involving low (e.g. substance abuse). Here we test hypothesis that lower is associated with structural differences regions, particularly right side, 61 normal healthy...
To determine whether neuroanatomically heterogeneous strokes causing hemichorea-hemiballismus localize to a common functional network.We identified 29 cases of lesion-induced from the literature and mapped each lesion volume onto reference brain. Using recently validated technique termed network mapping, we tested these lesions belonged same network. accomplish this, brain regions functionally connected was using connectome dataset healthy participants. Network maps were overlapped identify...
BackgroundNo consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to best method for targeting left dorsolateral prefrontal cortex (DLPFC) depression treatment. Two common methods are Beam F3 and 5.5 cm rule.ObjectiveEvaluate anatomical reliability of technician-identified DLPFC targets obtain average brain scalp MNI152 coordinates.MethodsThree trained TMS technicians performed repeated using both rule ten healthy subjects (n = 162). Average target locations were...
To evaluate lesion location after pediatric cerebellar tumor resection in relation to the development of severe cognitive and affective disturbances, or syndrome (CCAS).The postsurgical 195 patients with tumors was mapped onto a template brain. Individuals CCAS were matched 2 participants without by sex, age, volume. Lesion analyses included both hypothesis-driven evaluation outflow pathway (deep nuclei superior peduncles) data-driven multivariate symptom mapping. Lesion-associated networks...
Significance Hubs are highly connected brain regions that important for coordinating processing in networks and supporting cognition. There several different methods characterizing network hubs gray white matter, yet it is unclear which of these hub measures identify sites most critical Here, we use data from two large cohorts patients with focal damage to show lesions matter dense structural connections have the strongest association cognitive impairment, while functional centrality weaker...
BackgroundThe Beam F3 and 5.5 cm methods are the two most common targeting strategies for localizing left dorsolateral prefrontal cortex (DLPFC) treatment site in repetitive transcranial magnetic stimulation (rTMS) protocols. This prospective, randomized, double-blind comparative effectiveness trial assesses clinical outcomes these a naturalistic sample of patients with major depressive disorder (MDD) undergoing rTMS treatment.Methods105 adult MDD (mean age = 43.2; range 18–73; 66% female)...
Variation in emotional processes may contribute to aggressive and defiant behavior. This study assessed these problem behaviors a large sample of children adolescents relation the volume two cortical regions with prominent roles emotion processing, anterior cingulate cortex (ACC) ventromedial prefrontal (vmPFC). One hundred seventeen participants (61 boys, 56 girls), ages 7-17, were recruited from community. Aggressive behavior was measured using parent- teacher-reported Pediatric Behavior...
Research into the neural underpinnings of fear and fear-related pathology has highlighted role amygdala. For instance, bilateral damage to amygdaloid complex is associated with decreased appreciation danger recognition in humans, whereas enlarged amygdala volume internalizing syndromes. It unknown whether fearfulness are related absence pathology. We examined correlation between normal morphology 116 healthy children adolescents (60 boys, 56 girls, age 7–17 years). Fearfulness was measured...
Background. Accurate prediction of clinical impairment in upper-extremity motor function following therapy chronic stroke patients is a difficult task for clinicians but key prescribing appropriate therapeutic strategies. Machine learning highly promising avenue with which to improve accuracy practice. Objectives. The objective was evaluate the performance 5 machine methods predicting postintervention using demographic, clinical, neurophysiological, and imaging input variables. Methods. A...
Motor recovery following ischemic stroke is contingent on the ability of surviving brain networks to compensate for damaged tissue. In rodent models, sensory and motor cortical representations have been shown remap onto intact tissue around lesion site, but remapping more distal sites (e.g. in contralesional hemisphere) has also observed. Resting state functional connectivity (FC) analysis employed study compensatory network adaptations humans, mechanisms time course are not well understood....
Hubs in the human brain support behaviors that arise from network interactions. Previous studies have identified hub regions thalamus are connected with multiple functional networks. However, behavioral significance of thalamic hubs has yet to be established. Our framework predicts subregions strong properties broadly involved functions across cognitive domains. To test this prediction, we studied patients focal lesions conjunction analyses thalamocortical connectome. In our stronger were...
Understanding neural circuits that support mood is a central goal of affective neuroscience, and improved understanding the anatomy could inform more targeted interventions in disorders. Lesion studies provide method inferring anatomical sites causally related to specific functions, including mood. Here, we performed large-scale study evaluating location acquired, focal brain lesions relation symptoms depression. Five hundred twenty-six individuals participated across two (356 male, average...