A5080836420- Stuttering Research and Treatment
- Language Development and Disorders
- Phonetics and Phonology Research
- Reading and Literacy Development
- Neurobiology of Language and Bilingualism
- Glioma Diagnosis and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Radiation Therapy and Dosimetry
- Child Abuse and Trauma
- Species Distribution and Climate Change
- Advanced Radiotherapy Techniques
- RNA and protein synthesis mechanisms
- Indigenous Health, Education, and Rights
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Amphibian and Reptile Biology
- Brain Metastases and Treatment
- Genetic diversity and population structure
- Orthopaedic implants and arthroplasty
- Neuroblastoma Research and Treatments
- Delphi Technique in Research
- Advanced X-ray and CT Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Sex and Gender in Healthcare
- Ultrasonics and Acoustic Wave Propagation
- Cancer-related cognitive impairment studies
Vanderbilt University Medical Center
2019-2025
Northern Devon Healthcare NHS Trust
2024
Google (United States)
2019-2024
Royal Devon and Exeter Hospital
2023
Massachusetts General Hospital
1996-2022
Sandia National Laboratories
2022
Vanderbilt University
2014-2021
University of Siena
2021
Harvard University
2002-2020
University of Iowa Hospitals and Clinics
2019
The mRNA cap-binding protein (eukaryotic initiation factor 4E [eIF4E]) binds the m7 GpppN cap on mRNA, thereby initiating translation. eIF4E is essential and rate limiting for synthesis. Overexpression of transforms cells, mutations in arrest cells G, cdc33 mutants. In this work, we identified promoter region gene encoding eIF4E, because previously as a potential myc-regulated gene. support our previous data, minimal, functional, 403-nucleotide was found to contain CACGTG E box repeats, core...
Purpose There are sparse data defining the dose response of radiation therapy (RT) to hypothalamus and pituitary in pediatric young adult patients with brain tumors. We examined correlation between RT these structures development endocrine dysfunction this population. Materials Methods Dosimetric clinical were collected from children adults (< 26 years age) tumors treated proton on three prospective studies (2003 2016). Deficiencies growth hormone (GH), thyroid hormone,...
To evaluate lesion location after pediatric cerebellar tumor resection in relation to the development of severe cognitive and affective disturbances, or syndrome (CCAS).The postsurgical 195 patients with tumors was mapped onto a template brain. Individuals CCAS were matched 2 participants without by sex, age, volume. Lesion analyses included both hypothesis-driven evaluation outflow pathway (deep nuclei superior peduncles) data-driven multivariate symptom mapping. Lesion-associated networks...
Across nondestructive testing and structural health monitoring (SHM), accurate knowledge of the systems’ reliability for detecting defects, such as probability detection (POD) analysis is essential to enabling widespread adoption. Traditionally, this relies on access extensive experimental data cover all critical areas parametric space, which becomes expensive, heavily undermines benefit systems bring. In response these challenges, estimation based numerical simulation emerges a practical...
Abstract Many organisms depend on acoustic communication for myriad functions, and have evolved behaviours to minimize effects of naturally occurring interference. However, as habitats are subject increased alteration, anthropogenic noise becomes unavoidable, how animals overcome such interference is not well understood. In most ecosystems, only a subset frog species associated with disturbed habitats; the ability these exogenous suggests that habitat associations may be related species'...
Purpose For historical buildings, devastating fires often result in the destruction of cultural heritage. This study aims to establish a total framework for achieving fire compartmentation while maintaining culture value historic public building facilities, which are adapted provide business functions such as museums and attractions. Design/methodology/approach A conceptual was validated by triangulation, using primary data from three case studies (observational surveys interviews with key...
Whilst high levels of concern about the prevalence family violence within Indigenous communities have long been expressed, progress in development evidence-based intervention programs for known perpetrators has slow. This review literature aims to provide a resource practitioners who work this area, and framework from which culturally specific prevention can be developed delivered. It is suggested that effective responses need informed by models violence, significant needed develop...
BACKGROUND Radiotherapy (RT) in the pediatric brain tumor population causes late neurocognitive effects. In current study, authors investigated associations between clinical and dosimetric risk factors memory outcomes a cohort of patients treated with proton radiotherapy (PRT). METHODS A total 70 (median age at PRT, 12.1 years [range, 5.0‐22.5 years]) who were PRT identified baseline follow‐up evaluations visual verbal (Children's Memory Scale third edition Wechsler Scale). Whole‐brain as...
The purpose of this study was to determine (a) whether emotional reactivity and stress children who stutter (CWS) are associated with their stuttering frequency, (b) when the relationship between frequency is more likely exist, (c) how these associations mediated by a 3rd variable (e.g., sympathetic arousal).
This study aimed to identify cases of developmental stuttering and associated comorbidities in de-identified electronic health records (EHRs) at Vanderbilt University Medical Center, and, turn, build test a prediction model. A multi-step process including keyword search medical notes, text-mining algorithm, manual review was employed the EHR. Confirmed were compared matched controls phenotype code (phecode) enrichment analysis reveal conditions with (i.e., comorbidities). These phenotypes...
To determine whether phonological processing in adults who stutter (AWS) is disrupted by increased amounts of cognitive load a concurrent attention-demanding task.Nine AWS and 9 do not (AWNS) participated. Using dual-task paradigm, the authors presented word pairs for rhyme judgments and, concurrently, letter strings memory recall. The judgment task manipulated rhyming type (rhyming/nonrhyming) orthographic representation (similar/dissimilar). recall varied stimulus complexity (no letters, 3...
This study sought to determine whether respiratory sinus arrhythmia (RSA) and executive functions are associated with stuttered speech disfluencies of young children who do (CWS) not stutter (CWNS).
Purpose The purpose of this study was to assess changes in autonomic, behavioral, and acoustic measures response social stress adults who stutter (AWS) compared do not (ANS). Method Participants completed the State–Trait Anxiety Inventory ( Speilberger, Gorsuch, Luschene, Vagg, & Jacobs, 1983 ). In order provoke stress, participants were required complete a modified version Trier Social Stress Test (TSST-M, Kirschbaum, Pirke, Hellhammer, 1993 ), which included completing nonword reading...
Developmental stuttering is a speech disorder characterized by disruption in the forward movement of speech. This includes part-word and single-syllable repetitions, prolongations, involuntary tension that blocks syllables words, has life-time prevalence 6–12%. Within Vanderbilt's electronic health record (EHR)-linked biorepository (BioVU), only 142 individuals out 92,762 participants (0.15%) are identified with diagnostic ICD9/10 codes, suggesting large portion people who stutter do not...