A5084038131- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Childhood Cancer Survivors' Quality of Life
- Advanced Radiotherapy Techniques
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Chromatin Remodeling and Cancer
- Acute Lymphoblastic Leukemia research
- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Cardiac tumors and thrombi
- Cancer-related cognitive impairment studies
- Family Support in Illness
- Ethics and Legal Issues in Pediatric Healthcare
- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
- Hedgehog Signaling Pathway Studies
- BRCA gene mutations in cancer
- Chemotherapy-related skin toxicity
- Chemotherapy-induced cardiotoxicity and mitigation
- Palliative Care and End-of-Life Issues
- Ovarian cancer diagnosis and treatment
Massachusetts General Hospital
2015-2024
Harvard University
2018-2024
Boston University
2019
MGH Institute of Health Professions
2018
The physical properties of protons lower doses to surrounding normal tissues compared with photons, potentially reducing acute and long-term adverse effects, including subsequent cancers. magnitude benefit is uncertain, however, currently based largely on modeling studies. Despite the paucity directly comparative data, number proton centers patients are expanding exponentially. Direct studies potential risks benefits needed in children, who have highest risk radiation-related Pediatric...
BACKGROUND Radiotherapy (RT) in the pediatric brain tumor population causes late neurocognitive effects. In current study, authors investigated associations between clinical and dosimetric risk factors memory outcomes a cohort of patients treated with proton radiotherapy (PRT). METHODS A total 70 (median age at PRT, 12.1 years [range, 5.0‐22.5 years]) who were PRT identified baseline follow‐up evaluations visual verbal (Children's Memory Scale third edition Wechsler Scale). Whole‐brain as...
Background/Objectives: The Pediatric Proton Consortium Registry (PPCR) was established to expedite proton outcomes research in the pediatric population requiring radiotherapy. Here we introduce PPCR as a resource oncology community and provide an overview of data available for further study collaboration. Design/Methods: A multi-institutional registry integrated clinical, dosimetric, radiographic, patient-reported patients undergoing radiation therapy conceived May 2010. Massachusetts...
The Pediatric Proton/Photon Consortium Registry (PPCR) is a comprehensive data registry composed of pediatric patients treated with radiation. It was established to expedite outcomes-based research. attributes which allow the PPCR be successful collaboration are reviewed.Current eligibility criteria radiotherapy < 22 years at one 15 US participating institutions. Detailed health and treatment collected about disease presentation exposures, annually thereafter, in REDCap (Research Electronic...
Abstract Background The purpose of this analysis is to report long-term health-related quality life (HRQoL) among brain tumor survivors treated with proton therapy (PRT) at a very young age. Methods Fifty-nine children &lt;4 years old received PRT between 2000 and 2011. Forty families participated. HRQoL was assessed by child self-report (CSR; age ≥5) parent proxy (PPR; 2+) using the PedsQL Core. Results median 2.5 (range, 0.3–3.8) 9.1 (5.5–18) last follow-up. most common diagnoses were...
BACKGROUND To the authors' knowledge, health‐related quality of life (HRQOL) outcomes are not well described in patients with medulloblastoma. The use proton radiotherapy (RT) may translate into an improved HRQOL. In current study, authors report long‐term HRQOL proton‐treated pediatric METHODS study was a prospective cohort medulloblastoma who were treated RT and enrolled between August 5, 2002, October 8, 2015. Both child parent‐proxy Pediatric Quality Life Inventory (PedsQL) surveys...
Abstract Background Treatment for pediatric ependymoma includes surgical resection followed by local radiotherapy (RT). Proton RT (PRT) enables superior sparing of critical structures compared with photons, potential to reduce late effects. We report mature outcomes, patterns failure, and predictors outcomes in patients treated PRT. Methods One hundred fifty (&lt;22 y) World Health Organization grades II/III were PRT between January 2001 2019 at Massachusetts General Hospital....
Survivors of pediatric medulloblastoma experience long-term morbidity associated with the toxic effects postoperative radiotherapy (RT). Proton RT limits radiation dose to normal tissues thereby reducing side treatment while maintaining high cure rates. However, data on disease outcomes and proton remain limited.One hundred seventy-eight patients treated between 2002 2016 at Massachusetts General Hospital comprise cohort who were surgery, therapy, chemotherapy. We evaluated event-free...
Abstract Background Hippocampal avoidance (HA) has been shown to preserve cognitive function in adult patients with cancer treated whole‐brain radiation therapy for brain metastases. However, the feasibility of HA pediatric tumors not explored because concerns increased risk relapse peri‐hippocampal region. Our aim was determine patterns recurrence and incidence medulloblastoma (MB). Methods materials We identified MB protons between 2002 2016 who had recurrent disease. To estimate...
Cancer Informatics for Centers (CI4CC) is a grassroots, nonprofit 501c3 organization intended to provide focused national forum engagement of senior cancer informatics leaders, primarily aimed at academic centers anywhere in the world but with special emphasis on 70 National Institute–funded centers. This consortium has regularly held topic-focused biannual face-to-face symposiums. These meetings are place review and data science priorities initiatives, providing discussion strategic...
Abstract BACKGROUND Proton radiotherapy (PRT) is a highly targeted form of radiation that spares more normal brain tissue compared to modern photon radiotherapy. Therefore, we expect the late effect profile in children treated with PRT curable tumors should be improved. METHODS Between 2010-2022, 100 patients were enrolled, PRT, and then followed for disease control, hearing, neurocognitive endocrine outcomes. Late effects tumor treatment delivered graded using CTCAE v4.0. RESULTS Median age...