A5043731440- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Neuroblastoma Research and Treatments
- Radiation Therapy and Dosimetry
- Management of metastatic bone disease
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Radiation Dose and Imaging
- Testicular diseases and treatments
- Brain Metastases and Treatment
- Advances in Oncology and Radiotherapy
- Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Radiation Detection and Scintillator Technologies
- Advanced X-ray and CT Imaging
- Palliative Care and End-of-Life Issues
- Medical Imaging Techniques and Applications
- Head and Neck Surgical Oncology
- Lymphoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Vascular Tumors and Angiosarcomas
- Surgical site infection prevention
- Lung Cancer Diagnosis and Treatment
Sidney Kimmel Cancer Center
2019-2025
Sibley Memorial Hospital
2017-2025
Johns Hopkins University
2016-2024
Johns Hopkins Medicine
2016-2024
Center for Cancer and Blood Disorders
2019-2023
Children's National
2018-2023
Sidney Kimmel Comprehensive Cancer Center
2017-2020
Johns Hopkins Hospital
2020
Massachusetts General Hospital
2013-2018
Provision Center for Proton Therapy
2015-2016
This prospective phase II study was designed to assess disease control and describe acute late adverse effects of treatment with proton radiotherapy in children rhabdomyosarcoma (RMS).Fifty-seven patients localized RMS (age 21 years or younger) metastatic embryonal 2 10 years) were enrolled between February 2005 August 2012. All treated chemotherapy based on either vincristine, actinomycin, cyclophosphamide ifosfamide-based radiation. Surgical resection tumor site accessibility. Common...
BACKGROUND Proton radiotherapy remains a limited resource despite its clear potential for reducing radiation doses to normal tissues and late effects in children comparison with photon therapy. This study examined the impact of race socioeconomic factors on use proton therapy solid malignancies. METHODS evaluated 12,101 (age ≤ 21 years) National Cancer Data Base who had been diagnosed malignancy between 2004 2013 received photon‐ or proton‐based radiotherapy. Logistic regression analysis was...
ABSTRACT Background Rhabdomyosarcoma (RMS) is the most common pediatric head and neck soft‐tissue sarcoma. Intergroup Study I–IV demonstrated that patients with alveolar RMS (ARMS), Group III disease, or clinically involved regional lymph nodes had a worse prognosis. The outcomes prognostic features of nonorbital, nonparameningeal (NONPHN) treated in subsequent Children's Oncology (COG) trials have not been reported. Procedure Patients enrolled COG low‐risk (D9602 ARST0331),...
Abstract Background Radiation therapy (RT) planning is a time‐consuming process involving the contouring of target volumes and organs at risk, followed by treatment plan optimization. CT typically used as primary image modality it provides electron density information needed for dose calculation. MRI widely after registration to due its high soft tissue contrast. However, there exists uncertainties in registration, which propagate throughout errors, lead inaccuracies. MR‐only RT has been...
The Pediatric Proton/Photon Consortium Registry (PPCR) is a comprehensive data registry composed of pediatric patients treated with radiation. It was established to expedite outcomes-based research. attributes which allow the PPCR be successful collaboration are reviewed.Current eligibility criteria radiotherapy < 22 years at one 15 US participating institutions. Detailed health and treatment collected about disease presentation exposures, annually thereafter, in REDCap (Research Electronic...
Esthesioneuroblastoma (EN) of the paranasal sinus comprises less than 3% tumors in pediatric and adolescent patients [1]. The collective adult literature indicates a critical role for radiotherapy attaining cure [2], yet outcome data is limited. Radiation with EN can cause significant morbidity due to proximity structures. Proton offers potential dosimetric benefit that may improve long-term survival toxicity outcomes population [3].We retrospectively identified eight treated proton from...
Background Metastasectomy is standard of care for pediatric patients with metastatic sarcoma limited disease. For unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. Herein, the authors report results a prospective, multi‐institutional phase 2 trial SBRT in children and young adults sarcoma. Methods Patients aged >3 years ≤40 unresected, osseous nonrhabdomyosarcoma sarcomas soft tissue bone were eligible. received to dose 40 Gray (Gy) 5 fractions....
The practice of palliative radiation therapy (RT) is based on extrapolation from adult literature. We evaluated patterns pediatric RT to describe regimens used identify opportunity for future pediatric-specific clinical trials.Six international institutions with expertise completed a 122-item survey evaluating patients ≤21 years old 2010 2015. Two use proton RT. Palliative was defined as treatment the goal symptom control or prevention immediate life-threatening progression.Of 3,225...
Abstract Purpose Radiation therapy (RT) of pediatric brain cancer is known to be associated with long‐term neurocognitive deficits. Although target and organs‐at‐risk (OARs) are contoured as part treatment planning, other structures linked cognitive functions often not included. This paper introduces a novel automatic segmentation tool specifically designed for the unique challenges posed by patients undergoing RT, well its seamless integration into existing clinical workflow. Methods...
Brain metastases in pediatric osteosarcoma are infrequent but associated with a dire prognosis.
Primary head and neck mucosal melanomas (HNMMs) are rare tumors managed with surgery and/or radiotherapy associated poor outcomes. Given their radioresistance, high linear energy transfer neutrons may improve local control.We conducted a retrospective review of 14 patients HNMM treated at the University Washington from 1990 to 2012. Five had T3 disease, 9 T4 3 regional nodal 4 distant metastases diagnosis. sites were sinonasal (n=10), lip (n=2), palate (n=2). Ten initial surgical...
Abstract Purpose To evaluate dosimetric changes detected using synthetic computed tomography (sCT) derived from online cone‐beam CTs (CBCT) in pediatric patients treated intensity‐modulated proton therapy (IMPT). Methods Ten undergoing IMPT and aligned daily gantry‐mounted CBCT were identified for retrospective analysis with anatomical sites fully encompassed the field of view. Dates when patient received both a quality assurance CT (qCT) routine evaluation. sCTs generated based on...
The presence of the novel coronavirus (COVID-19) pandemic1 prompted a structured response across Johns Hopkins integrated network radiation oncology facilities in Maryland and District Columbia. department has developed comprehensive reference document that serves as resource for our staff summary to pandemic. full been posted on American Society Radiation Oncology "ROhub" web page.2 We present here several excerpts from overall program we believe may be interest can serve community at large.
Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role local control these tumors, which often arise adjacent to critical structures and growing organs. The physical properties proton beam radiotherapy provide advantage over standard photon radiation by eliminating excess dose deposited beyond target volume, thereby reducing both delivered non-target as well total patient....
Recent single institution, phase II evidence has demonstrated the feasibility and efficacy of ultra-hypofractionated, preoperative photon therapy in 5 fractions for treatment soft tissue sarcoma (STS). Our purpose was to evaluate dosimetric benefits modern scanning beam proton compared with conventional radiation (RT) neoadjuvant adult extremity STS.