A5004293175- Effects of Radiation Exposure
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Radiation Therapy and Dosimetry
- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Management of metastatic bone disease
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
- Sarcoma Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- Cutaneous lymphoproliferative disorders research
- Ocular Oncology and Treatments
- Vascular Tumors and Angiosarcomas
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Sinusitis and nasal conditions
- Vascular Malformations Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Lymphoma Diagnosis and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2019-2025
Scientific Center of Children's Health
2017-2020
Myeloablative Total Body Irradiation (TBI) is an important modality in conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), especially children with high-risk acute lymphoblastic leukemia (ALL). TBI practices are heterogeneous and institution-specific. Since associated multiple late adverse effects, recommendations may help to standardize improve the outcome versus toxicity ratio children. The European Society Paediatric Oncology (SIOPE) Radiotherapy Working Group...
The practice of palliative radiation therapy (RT) is based on extrapolation from adult literature. We evaluated patterns pediatric RT to describe regimens used identify opportunity for future pediatric-specific clinical trials.Six international institutions with expertise completed a 122-item survey evaluating patients ≤21 years old 2010 2015. Two use proton RT. Palliative was defined as treatment the goal symptom control or prevention immediate life-threatening progression.Of 3,225...
Abstract Graft failure (GF) remains a serious issue of hematopoietic stem cell transplantation (HSCT) in inborn errors immunity (IEI). Second HSCT is the only salvage therapy for GF. There are no uniform strategies second HSCTs and limited data available on outcomes. 48 patients with various IEI received allogeneic from 2013 to 2020. Different conditioning regimens were used, divided into two main groups: containing myeloablative doses busulfan/treosulfan ( n = 19) lymphoid irradiation 2–6...
Total body irradiation (TBI) in combination with chemotherapy is widely used as a conditioning regimen pediatric and adult hematopoietic stem cell transplantation (HSCT). The of TBI has demonstrated superior survival outcomes patients acute lymphoblastic myeloid leukemia when compared regimens based only on chemotherapy. clinical application intensity-modulated radiation therapy (IMRT)-based methods (volumetric modulated arc (VMAT) TomoTherapy) seems to be promising been actively worldwide....
Purpose/Objectives: There is little consensus regarding the application of stereotactic radiotherapy (SRT) in pediatrics. We evaluated patterns pediatric SRT practice through an international research consortium. Materials and Methods: Eight institutions with expertise completed a 124-item survey evaluating use for patients 21 years old younger. Frequencies median margins applied without were evaluated. Results: Across institutions, 75% reported utilizing was used 22% brain, 18% spine, 16%...
Background: Lower-dose cone-beam computed tomography protocols for image-guided radiotherapy may permit target localization while minimizing radiation exposure. We prospectively evaluated a lower-dose protocol central nervous system across multinational pediatrics consortium. Methods: Seven institutions employed (weighted average dose 0.7 mGy) patients ≤21 years. Treatment table shifts between setup with surface lasers versus were used to approximate accuracy, and vector magnitudes these...
This study presents the experience of one center in development and implementation two different methods totalbody irradiation (ТОТ) based on radiation therapy with intensity modulation, namely, Helical TomoTherapy (HT) Volumetric Modulated Arc Therapy (VMAT), implemented classic linear accelerator Elekta Synergy. The aim work is comparison TBI methods, as well a description process introducing these into routine practice radiotherapy department. was approved by Independent Ethics Committee...
A case of clinical observation a Sinonasal Renal Cell-like Adenocarcinoma in patient 17 years is described. In the article description Cell – like described for first time domestic literature and histological features are analyzed detail. Patient's parents agreed to use personal dats photos research publications.
Background. Combination of total body irradiation (TBI) with chemotherapy is widely used technique for conditioning before hematopoietic stem cell transplantation patient hematological malignancies worldwide. Best results patient’s survival were showed in comparison regimen included only chemotherapy. Aim – development TBI at children the help TomoTherapy equipment and including it to protocol allogenic bone marrow transplantation. Materials methods. During period between July 2014 February...
Purpose: Combination of total body irradiation (TBI) with chemotherapy is widely used technique for conditioning before hematopoietic stem cell transplantation patient hematological malignancies worldwide. Total patients high height has to be divided into two parts: upper part the patient’s (including head, and legs) lower leg). There an area in which fields overlap each other – junction area. The aim this work development verification simple that would provide dose distribution from 90 125...
Primary intracranial germ cell tumors are rare heterogeneous group of neoplasms presented several histological types with different biological profile and response to therapy. Pure germinomas make up no more than 5 % malignant the central nervous system in children, bifocal account for only 5–10 all germinomas. Radiotherapy chemotherapy usually used tumors. The choice initial therapy options is dependent on variants tumors, prevalence process (M-stage). Vascular malformations brain...
Malignant fibrous histiocytoma (MFH) is a rare “NON-RMS-LIKE” pediatric tumor with highly malignant clinical behavior, high metastatic potential and overall 5-year survival around 65-70%. Soft tissue sarcoma diagnostic work-up optimal combination of systemic therapy local approaches are one of the most challenging issues in modern oncology. To present a case of parameningeal undifferentiated pleomorphic 7-year old child treated adaptive conformal radiotherapy aimed at control. We...
This review provides information on total body irradiation (TBI), including the history of development method, a brief description classical dose delivery methods, and main difficulties it's using. Recent years, TBI based IMRT (Intensity Modulated Radiation Therapy) has been increasingly used. It is assumed that toxicity therapy decreases without an increasing relapse probability. Using for also allows to unify distribution within patients and, most importantly, us clear quantitative...