A5029010025- Tumors and Oncological Cases
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Vascular Malformations and Hemangiomas
- Renal and related cancers
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Oral and Maxillofacial Pathology
- Cancer therapeutics and mechanisms
- Pancreatic and Hepatic Oncology Research
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Lung Cancer Treatments and Mutations
- Teratomas and Epidermoid Cysts
- Immunodeficiency and Autoimmune Disorders
- Lymphatic Disorders and Treatments
- IgG4-Related and Inflammatory Diseases
- Bone Tumor Diagnosis and Treatments
- Hematopoietic Stem Cell Transplantation
- Blood transfusion and management
- Congenital Diaphragmatic Hernia Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lung Cancer Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
Ministry of Health of the Russian Federation
2019-2024
Russian Cancer Research Center NN Blokhin
2024
University of California, Davis
2021
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2018-2020
In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup unique epidemiology, clinical care needs, societal impact. Comprehensive estimates in (aged 15-39 years) lacking. To address this gap, we analysed results from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019, focus on outcome disability-adjusted life-years (DALYs), to inform control measures adults.
Background: Chyloperitoneum (CP) and chylothorax (CT) are rare conditions that have a high mortality rate unclear treatment options. Their incidence in neonates ranges from 1 20000 to 187000 live births. This study aims evaluate the effectiveness of synthetic somatostatin analog (octreotide) sirolimus therapy treating chylous pleural peritoneal collections newborns infants. Methods: We conducted retrospective analysis 10 children with either or chyloperitoneum, treated our department between...
Introduction . Massive perioperative blood loss that accompanies major surgical interventions is a specific critical condition, the pathogenesis of which dominated by severe hypovolemia, anemia, and threatening coagulopathy in combination with powerful shockogenic sympathoadrenal stress. Both massive itself transfusion are associated significant risk serious complications, including death. It worth noting information on survival patients after replacement several circulating volume (CBV)...
Background . Proteus syndrome is extremely rare congenital multisystem disease with high variability in clinical manifestations. Its prevalence unknown, there are less than 200 cases the world literature. The a classic example of somatic mosaicism, and all target drugs for its management based on it. Clinical case description. This article describes two variants nucleotide sequence AKT1 gene, mosaic form, revealed by NGS method. Target drug (mTOR-inhibitors group) was assigned one case....
Background: Chyloperitoneum (CP) and chylothorax (CT) are rare conditions that have a high mortality rate unclear treatment options. Their incidence in neonates ranges from 1 20000 to 187000 live births. This study aims evaluate the effectiveness of synthetic somatostatin analog (octreotide) sirolimus therapy treating chylous pleural peritoneal collections newborns infants. Methods: We conducted retrospective analysis 10 children with either or chyloperitoneum, treated our department between...
The clinical case of a giant congenital germ cell tumor (immature teratoma, 2 grade) soft tissues the head and neck with destruction large wing sphenoid bone, with spreading to oral cavity transition beyond middle line, infiltration tongue, complete obstruction nasopharyngeal child 15 days life. article describes Specific features performing surgical intervention are described taking into account prevalence process. discussed issues teratoma classification, methods diagnosis, provision...
Late diagnostics of oncological diseases (OD) in children accounts for significant deaths pediatric oncology. As a result it the overall survival rate is decreasing and level complications increasing. There are no effective screening programs malignant neoplasms as yet. Programs intent to spread early OD require efforts fields increasing awareness among practitioners optimization routing. The Article provides up-to-date information on importance oncology, various international campaigns...
Somatic translocations involving the NTRK genes occur in 0.34–2.2% of all malignant neoplasms children. TRK inhibitors whose efficacy has been demonstrated prospective clinical studies expand treatment options for patients with solid tumors harboring gene rearrangements. The aim our study was to summarize first Russian experience use inhibitor entrectinib extracranial fusion-positive included compassionate program. This approved by Independent Ethics Committee and Academic Council Dmitry...
Introduction: Renal cell carcinoma (RCC) is a very rare pediatric renal tumor. Robust evidence to guide treatment lacking and knowledge on targeted therapies immunotherapy mainly based adult studies. Currently, the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) 2016 UMBRELLA protocol recommends sunitinib for metastatic or unresectable RCC. This retrospective study describes effects tyrosine kinase inhibitors (TKI), anti-programmed death 1 (PD-(L)1) monoclonal...
Immune checkpoint inhibitors (ICT) therapy is a successful immunotherapy (IT) strategy that quite effective in number of patients with non-small cell lung cancer, melanoma, bladder breast cancer and others. Nevertheless, there need predictive markers for ICT personalized IT as far large group patients, the proportion which varies depending on tumor, who do not have clinical response to such therapy. The review summarizes theoretical aspects results trials dedicated various efficiency...
PIK3CA-Related Overgrowth Spectrum (PROS) refers to rare syndromes, which are characterized by malformations and excessive tissue growth caused somatic mutations in the PIK3CA gene occurring during embryogenesis. This article discusses pathogenesis, clinical picture, diagnosis treatment of these syndromes. Some illustrations used this copied from other resources, rights authors respected not violated. The appropriate permissions journals have been obtained.
A case of clinical observation a Sinonasal Renal Cell-like Adenocarcinoma in patient 17 years is described. In the article description Cell – like described for first time domestic literature and histological features are analyzed detail. Patient's parents agreed to use personal dats photos research publications.
B-cell lymphoma is unclassifiable, with signs intermediate between diffuse large-cell and Hodgkin's (LH), a rare aggressive an uncertain prognosis that has specific morphological immunophenotypic characteristics characteristic of both B-large-cell lymphoma. In this article, the comparative NIVCL various variants large cell lymphomas are presented, as well description clinical case NVCL in child 3 years. Patient's parents agreed to use personal dats photos research publications.
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare type with uncertain clinical behavior. The commonly occurred in the head and neck region. Radical surgical resection standard treatment, which often associated high risks severe postoperative complications due to localization. Alternative methods treatment including chemotherapy/radiotherapy are used metastatic, locally advanced relapsed cases MNTI. aim this study was analyze morphological characteristics tumor, evaluate...
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood, accounting for 6—10 % all malignant neoplasms in children. One fundamentally important problems clinician stratification risk group and definition treatment tactics patients with NB. In this work, we studied dependence expression CRABP1 protein primary focus metastases on type genetic disorders (amplification MYCN gene, deletion 11q23 locus) effect therapy
A vertically integrated management system in the health care sector Russian Federation is based on model of functioning national centers. One key components achieving success interaction center with a leading professional society. The aim article to present experience joint work National Society Pediatric Hematologists and Oncologists (NSPHO) centers excellence pediatric cancer Russia field development oncology-hematology Russia. In order accomplish task building care, comprehensive program...
<h3>Background</h3> Immunoglobulin G4-related disease (IgG4-RD) is a chronic systemic inflammatory condition with an unclear pathophysiology and IgG4-positive plasma cells infiltration of various organs parts the body. If untreated, can lead to fibrosis irreversible organ damage. IgG4-RD mostly has been described in adults, hence it generally unknown among paediatricians. <h3>Objectives</h3> We conducted retrospective analysis clinical features response therapy five patients (one female,...
The receptor tyrosine kinase genes (NTRK1, 2, 3) are proto-oncogenes that found in various solid tumors children and adults. Currently, next-generation sequencing (NGS) is the preferred platform for detecting NTRK gene translocations. scientific literature presents data on effectiveness of entrectinib patients with translocation NTRK, ROS1 ALK genes, regardless partner gene. In future, entreсtinib therapy can become an alternative to chemotherapy or be used combination complex treatment both...
Infantile fibrosarcoma (IF) is a rare soft tissue sarcoma that occurs with frequency of 1% all cases malignant neoplasms in children the first year life. IF most often affects tissues upper and lower extremities. Rare localizations include trunk, head neck, gastrointestinal tract. The article describes clinical case congenital chest wall newborn, as well literature review.
On October 19, 2022, the Council of Experts considered and discussed a number issues related to treatment patients with infantile hemangioma in Russian Federation.
PROS (PIK3CA-Related Overgrowth Spectrum) encompasses vascular malformations, lipomatosis and other multiple congenital anomalies resulting from activating somatic mutations in the PIK3CA gene. includes macrodactyly, hemimegalencephaly, muscle hemihypertrophy, facial infiltrating CLOVES, megalencephaly, malformations (capillary, venous, lymphatic, arteriovenous combined malformations), skin disorders, epidermal nevi, etc. The experts of Russian Society Pediatric Oncologists Hematologists,...
Introduction. Lymphatic malformations (LM) are a congenital pathology of lymphatic vessels that arose during embryogenesis. The relevance the research topic is due to rarity, variety clinical manifestations, and lack recommendations for treatment. Aim. To evaluate our experience surgical conservative treatment LM in department newborns infants.
 Materials methods. We performed retrospective analysis infants with various forms treated at from 2017 2022. study protocol was approved by...
The article presents a case of development bone tissue damage as manifestation toxicity against the background differentiation therapy 13-cis-Retinoic acid in patient with neuroblastoma (NB) high-risk group. This clinical example is interest model differential diagnosis metastatic osseous lesion patients disseminated NB and rare variant during specific therapy.
IgG4-related disease is an extremely rare disorder, сcharacterized by the inflammatory infiltration of various organs, with predominance IgG4-positive plasma cells, fibrosis and high IgG4 concentration. Treatment regiments have not been optimized, especially in children. Here we discuss a case orbit 13 year old boy our new treatment approach involving JAK-kinase inhibitor ruxolitininb. The article also presents analysis state problem it he world, including terminology, historical references,...