A5055052557- Cervical Cancer and HPV Research
- Genital Health and Disease
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Hepatitis B Virus Studies
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Reproductive tract infections research
- Lung Cancer Treatments and Mutations
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Esophageal Cancer Research and Treatment
- Vascular Tumors and Angiosarcomas
- Monoclonal and Polyclonal Antibodies Research
- Peroxisome Proliferator-Activated Receptors
- Pharmacogenetics and Drug Metabolism
- Reproductive Biology and Fertility
- Chemical Safety and Risk Management
- bioluminescence and chemiluminescence research
Ministry of Health of the Russian Federation
2019-2020
Russian Cancer Research Center NN Blokhin
2002-2014
Hospital de Clínicas de Porto Alegre
2011
Universidade Federal do Rio Grande do Sul
2011
Russian Academy of Sciences
1985-2010
Academy of Medical Sciences
1995-2010
Russian Medical Academy of Continuous Professional Education
2003-2004
University of Siena
2003
Latvian Biomedical Research and Study Centre
2003
German Cancer Research Center
1995
The impairment of retinoic acid (RA)-dependent signaling is a frequent event during carcinogenesis. Cellular acid-binding proteins (CRABP1 and CRABP2) are important modulators RA activity. Up to date, the role these in cancer progression remains poorly investigated. Here, we studied for first time simultaneous messenger RNA (mRNA) protein expression CRABPs non-small cell lung (NSCLC) samples. CRABP1 CRABP2 mRNA levels were elevated 42 56 % NSCLC samples, respectively. Decrease was...
CRABP1 (cellular retinoic acid binding protein 1) belongs to the family of fatty proteins. Retinoic is only known functional activity this protein. The role in human carcinogenesis remains poorly understood. Here, for first time we demonstrated pro-metastatic and pro-tumorigenic mesenchymal tumors. Further analysis revealed that effect does not depend on activity. These results suggest could have an alternative intracellular contributes high malignancy transformed cells. Microarray detected...
Objectives. Human papillomavirus (HPV) infection is a sexually transmitted disease (STD) and the single most important etiological agent of cervical cancer. In parallel with increase STDs because lack any organized cancer screening in new independent states former Soviet Union, incidence mortality rates are rapidly rising. This first report from an ongoing European Commission-funded (INCO-Copernicus Program) cross-sectional cohort study (focused on key issues this major health problem...
ABSTRACT The rates of acquisition and the times incident high-risk (HR) human papillomavirus (HPV) infections Pap smear abnormalities their predictive factors were analyzed in women participating a multicenter screening study three countries New Independent States former Soviet Union. 423 patients prospectively monitored for mean 21.6 months. At baseline, 118 HR HPV DNA negative (Hybrid Capture II assay) (group 1), 184 positive 2), 121 3). time to an abnormal (19.4 months) was significantly...
In Brief Background On a global scale, the New Independent States (NIS) of former Soviet Union have an intermediate incidence cervical cancer, main etiologic factor which is human papillomavirus (HPV), major sexually transmitted disease (STD). Recently, prevalence all STDs has exploded in these countries. Goal The goal this study was to examine sexual habits and HPV among females three NIS Study Design multinational (European Community-funded) trial, series 3,175 consecutive female patients...
In addition to oncogenic ‘high-risk’ human papillomaviruses (HR-HPV), several co-factors are needed in cervical carcinogenesis, but it is poorly understood whether these HPV associated with incident intraepithelial neoplasia (CIN) grade 1 different from those required for progression CIN2 and CIN3. To gain further insights into the true biological differences between CIN1, CIN3, we assessed increasing risk of Data New Independent States Former Soviet Union (NIS) Cohort ( n = 3187) Latin...
Abstract Background: The growth-controlling functions of the high-risk human papillomaviruses (HPV) depend on their ability to interact with several cellular proteins, including key regulatory proteins cell cycle. We have examined value cycle as predictors intermediate end point markers in cervical carcinogenesis: (a) grade intraepithelial neoplasia (CIN), (b) HPV type, (c) clearance/persistence HPV, and (d) disease outcome women participating a multicenter follow-up study three New...
Data are controversial as to the role of menarche age a risk factor high-risk human papillomavirus (HR-HPV) infections. The objective this study was analyse estimates for at determinant cervical intraepithelial neoplasia (CIN) and HR-HPV A cohort 3187 women were stratified into three groups according their menarche: (i) <13 years age; (ii) those between 13 14 (iii) >15 age. These analysed predictors (a) HR-HPV, (b) high-grade CIN (c) outcome cytological abnormalities during prospective...
Epithelial kidney tumors induced in CBA male mice by 1,2-dimethylhydrazine (DMH) were studied histochemically and immunohistochemically. A total of 48 histologically diagnosed as clear-cell, acidophilic, or mixed adenomas located the renal cortex. Gamma-glutamyl transpeptidase (GGT) was strongly positive normal proximal convoluted tubules, slightly cells Bowman's capsule, negative 47 examined. Antibodies against new antigen obtained from mouse liver oval cells, A6, also used. This is tubules...
Mouse renal cell tumors (RCTs) were induced in male CBA mice by 5 subcutaneous injections of 8 mg 1,2-dimethylhydrazine (DMH)/kg body weight once a week. After lag period 2 yr kidneys removed, and serial cryostat sections the histochemically analyzed for following parameters: glycogen content, basophilia, activities synthase (SYN), phosphorylase (PHO), glucose-6-phosphatase (G6Pase), glucose-6-phosphate dehydrogenase (G6PDH), hexokinase (HK), pyruvate kinase (PK), lactate (LDH), malic enzyme...
CBA male mice treated with 1,2-dimethylhydrazine (DMH) developed high incidence (up to 97%) of pararenal angiosar-comas. Castration that preceeded DMH-treatment almost completely inhibited the induction these tumours while castration followed had on influence their development. Testosterone propionate (TP) was efficient in restoring DMH-induced castrated males only when given simultaneously DMH and totally inefficient after cessation DMH-administration. Castrated female 92% angiosarcomas...
Summary To make feasible future clinical trials with new-generation human papillomavirus (HPV) vaccines, novel virological surrogate endpoints of progressive disease have been proposed, including high-risk HPV (HR-HPV) persistence for six months (6M+) or 12 (12M+). The risk estimates (relative risks [RRs]) these ‘virological endpoints’ are influenced by several variables, not yet validated adequately. We compared the impact three referent groups: (i) HPV-negative, (ii) HPV-transient, (iii)...
Considering the fact that group of neuroendocrine carcinomas (NECs) grade 3 is heterogenous, in year 2017 a new subgroup welldifferentiated tumors (NETs G3) was described. NETs G3 are with more favorable prognosis and less sensitive to platinum-based chemotherapy regimens than NECs, they also have peculiar morphogenetical qualities: lower ki‑67 index (mean 35.0 %), higher somatostatin receptors expression, absence DAXX/ATRX/MEN 1 genes mutation, p53 expression TP53 mutation. Nowadays...
Abstract1. Rat hepatoma 27 after intrahepatic transplantation shows a low but detectable level of cytochrome P450 and P450-dependent activities. The same transplanted intramuscularly does not show amount activities.2. Different types P4501A inducers were able to induce 1A isoforms in the transplants intramuscular transplants.3. Immunohistochemical analysis demonstrates that all cells into liver could be induced with 1A-inducer. adenomatous structures are reactive antibodies.
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood, accounting for 6—10 % all malignant neoplasms in children. One fundamentally important problems clinician stratification risk group and definition treatment tactics patients with NB. In this work, we studied dependence expression CRABP1 protein primary focus metastases on type genetic disorders (amplification MYCN gene, deletion 11q23 locus) effect therapy