665 Background: Neuroendocrine gastric tumors (gNETs) type 1 are associated with chronic autoimmune atrophic gastritis, hypergastrinemia and usually have multifocal lesions high frequency of recurrence (up to 70% for 2 years). Somatostatin analogs (SA) showed promising data in neoadjuvant setting 84% complete responses a small retrospective trial. The aim this study was evaluate the efficacy adjuvant treatment SA recurrent gNETs 1. Methods: This retrospective, single-center included patients...

659 Background: Gastrointestinal (GI) neuroendocrine carcinomas (NEC) are rare tumors and account for 3% of all NECs. Despite the differences in genetic characteristics, treatment principles GI NECs extrapolated from lung The standard first-line therapy is platinum etoposide-containing regimens, which allow to achieve a median PFS 5-6 months. A small retrospective study demonstrated potential effectiveness mFOLFIRINOX regimen with 5.4 months, despite that majority patients (pts) received...

AIM : To determine significant factors affecting the survival of patients with ectopic ACTH syndrome (EAS). MATERIALS AND METHODS A multi-center, observational study a retrospective analysis EAS. The end point was fatal outcome from various causes. In order to identify predictors or mortality, univariate and multifactorial Cox regression analyses were carried out. ROC-analysis used prognostic threshold values individual predictors. out using Kaplan-Mayer method. Statistical data processing...

In this clinical case we analyzed the need for a correct algorithm examining patients with liver tumors when making primary diagnosis, thus it significantly affects prognosis and course of disease. We demonstrate capabilities various diagnostic methods in differential diagnosis focal lesions. Our confirms optimal routing schemes to specialized centers that have all necessary resources perform types methods, including nuclear medicine as well presence multidisciplinary team specialists. The...

Aim. To study the immediate efficacy, tolerability and predictors of response to prolonged-acting somatostatin analogues (SSAs) in patients with ectopic ACTH syndrome (EAS). Materials methods. A multicenter, observational a retrospective analysis. The effectiveness treatment was evaluated every 12–24 weeks by activity hypercortisolism, clinical symptoms disease, control tumor growth. Patients were conditionally divided into “responders” “non-responders” at time points 6, 12 24 months....

Introduction : Pheochromocytoma (PC) and paraganglioma (PG) are rare neuroendocrine tumors derived from adrenal chromaffin cells. The main options of systemic therapy for PC / PG alkylating agent-based chemotherapy (ChT) targeted with sunitinib. There no comparative data on the efficacy these options, which became purpose this study. Materials methods This retrospective single-center study included patients over 18 y. o. who received ChT or first line treatment metastatic September 2015 to...

Considering the fact that group of neuroendocrine carcinomas (NECs) grade 3 is heterogenous, in year 2017 a new subgroup welldifferentiated tumors (NETs G3) was described. NETs G3 are with more favorable prognosis and less sensitive to platinum-based chemotherapy regimens than NECs, they also have peculiar morphogenetical qualities: lower ki‑67 index (mean 35.0 %), higher somatostatin receptors expression, absence DAXX/ATRX/MEN 1 genes mutation, p53 expression TP53 mutation. Nowadays...

This article describes a new affordable diagnostic method of neuroendocrine tumors, shows the basic information on it’s conduction and interpretation results. Scintigraphy tumors with 99m Tc-Tectro-tyd is alternative more that allows you to determine tumor receptor status, assess prevalence process plan therapy. study may also be first step in planning radionuclide therapy for patients tumors. Also there short review teranostics.

The study objective is to summarize clinical experience in the treatment of esthesioneuroblastoma (ENB) accumulated by specials at N.N. Blokhin National Medical Research Center Oncology. Materials and methods . We analyzed data 115 ENB patients who had undergone between 1965 2019. Results 15-year overall survival rate was 1.2–1.7 times higher receiving comprehensive (47.7 ± 11.3 %) than those other types therapy. In addition that, ensured highest rates 3-year, 5-year, 10-year relapse-free...

he disease incidence of neuroendocrine tumors (NET) is increasing every year. Neuroendocrine Grade 1 and 2 have a more favorable prognosis than 3. When we are talking about NET with non-detected initial focus, the 10-year survival rate 22 % [1]. Therefore, it necessary to make effort use all technical abilities localize primary tumor, even in presence metastases, because resection tumor(s) can increase disease-free overall rate. Also, choice chemotherapy drug or appointment biotherapy may...

Introduction. In patients with neuroendocrine neoplasms it is necessary to search for new prognostic factors identify a subgroup of who will benefit from drug treatment. Aim. The aim the study was an optimization Aranoza-based therapy in by using both morphological and clinical as predictors treatment efficacy. Materials methods. A total 122 were enrolled assessed radiological response (RECIST 1.0) progression-free survival. Results. Aranoza its combinations had similar localization...

Purpose: Exploring methods to improve diagnosis of neuroendocrine tumors (NET) in different locations using somatostatin receptors scintigraphy with 111In-octreotide. Material and methods: The study included 125 patients NET locations. Activity injected 111In-octreotide was 200–250 MBq (effective dose – 0.054 mSv/MBq), which allows carry out a planar as single photon emission computed tomography. performed after 24 hours on intravenous injection indicator the combined SPECT/CT machine Symbia...

Background : The utility of biochemical markers in the monitoring treatment efficacy patients with neuroendocrine tumors (NETs) goes beyond any doubt. However, there are still no clear criteria for assessment clinically significant abnormalities main NET biomarkers chromogranin A (CgA) and serotonin. Aim To evaluate value serial measurement serum CgA serotonin effect patients. Materials methods Serum levels were measured 107 NETs at baseline 3–4 weeks after end (chemotherapy, biotherapy), as...

The most common anatomical localization of neuroendocrine neoplasms (NEN) are the digestive and bronchopulmonary systems, total proportion which exceeds 90 % cases this group tumors. In turn, remaining represented by extremely rare primary head neck, skin, female genital organs, mammary gland, bladder kidney. Due to observations lack standardized approaches diagnosis treatment kidneys significant clinical interest. true incidence NENs kidney has not yet been established. We carried out a...

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms from cells the diffuse neuroendocrine system. Chromogranin B (CgB) is an acidic protein granin family, which can be used to detect tumours nature. Analysis levels and evaluation diagnostic efficiency CgB in blood serum patients with NETs various localizations. Patients (n=121) without specific treatment were examined. In study presented next localizations: 74 - pancreas, 20 stomach, 12 large intestine, 15 other localizations...

A combined approach to cytoreduction in a patient with neuroendocrine tumor G1 the ileum multiple bilobar metastases G2 liver, originally considered as candidate only for drug therapy, has been demonstrated. The first stage was laparoscopic resection of ileocecal segment intestine, followed by interventional radiological intervention — two-stage selective transarterial oil chemoembolization liver bleomycin. As result, 90 % cytoreduction, suppression clinical manifestations, normalization...

The paper covers the most important topographic-anatomic and histological characteristics of vagina, gives general information on epidemiology primary vaginal cancer (VC), rules its staging, describes frequently encountered morphological types this tumor, indicates properties features course neuroendocrine tumors (NETs), including common manifestations carcinoid syndrome symptoms tumor hypersecretion a number biologically active substances. It also sites NETs, their classification according...

Journal of Malignant tumoursХимиотерапия метастатических нейроэндокринных опухолей аранозой в монорежиме и комбинации с капецитабином темозоломидом ПОЛОЗКОВА СВЕТЛАНА АЛЕКСАНДРОВНА, ОРЕЛ НАДЕЖДА ФЕДОРОВНА, МАРКОВИЧ АЛЛА АНАТОЛЬЕВНА, КУЗЬМИНОВ АЛЕКСАНДР ЕВГЕНЬЕВИЧ, ГОРБУНОВА ВЕРА АНДРЕЕВНА В статье представлены результаты клинического исследования, целью которого являлась оценка эффективности безопасности режимов химиотерапии на основе отечественного производного нитрозомочевины Аранозы,...